Initial Test Research Articles

A block-spectral adaptive H-/p-refinement strategy for shock-dominated problems

An adaptive H-/p-refinement strategy using a novel sensor is devised and tested in a block-spectral compressible Euler code equipped with adaptive-mesh refinement (AMR) and high-order flux-reconstruction numerics. At each Gauss quadrature point (or solution point) within each spectral block (or mesh element) the discrete velocity jump ΔU = ∂U/∂y1Δy1+∂V/∂y2Δy2+∂W/∂y3Δy3 is calculated and normalized by the local speed of sound, a. The grid spacing, Δxi, is calculated in each direction as the distance between auxiliary Gauss-Lobatto points, staggered relative to the solution points. The polynomial order is increased from p=0 to p=pmax in regions of weak compression, (ΔU/a)crit<ΔU/a<0 and kept at p=pmax in regions of flow expansion ΔU/a≥0, while staying at the H=0 base mesh level. Regions experiencing strong compressions, i.e. ΔU/a<(ΔU/a)crit, are H-refined up to H=Hmax where Hmax is applied at the location of maximum compression, ΔU/a=min(ΔU/a) in the domain, while keeping p=0 to guarantee robustness and monotonicity of the solution in the H refined region. The critical value of (ΔU/a)crit= -0.06 is found to effectively separate smooth and non-smooth solution regions, supported by a 1D detonation initiation test case in ideal gas and a shock-to-detonation transition in high explosives. Using this value, the Sod shock tube, Shu-Osher problem, double Mach reflection and a 2D detonation in a high-explosive are simulated with the proposed adaptive H-/p-refinement. In the Sod shock tube case, p-refinement resolves the (weak) contact discontinuity while H-refinement enhances the grid resolution in the shock exploiting the monotonicity of the p=0 reconstruction. For the Shu-Osher problem, p-refinement captures the small-scale oscillations trailing the shock that would be otherwise attenuated, while H-refinement triggered by the ΔU-sensor appropriately tracks the shock. In the double Mach reflection problem, H-refinement confines the numerical diffusion around the reflected shock while p-refinement recaptures many physical features trailing the shock. Finally, in the 2D high-explosive detonation case, H-refinement follows the leading shock and resolves the curvature of the detonation wave, while p-refinement adds resolution to the trailing reaction zone. Finally, the proposed methodology is tested in a detonation-wave propagation test case in high-explosives with numerical predictions comparing favorably against experiments.

Investigation on the fatigue crack propagation of rock-concrete interface under fatigue loading below the initial cracking load

The fatigue crack propagation of the composite rock-concrete interface under constant-amplitude flexural fatigue loading below the initial cracking load was investigated in the present study. Fatigue pre-crack initiation and propagation tests were first conducted on three types of rock-concrete interfaces under three-point bend loading. It was shown that for the rock-concrete interface, the damage evolution throughout the fatigue loading process can be divided into deceleration and acceleration stages according to the rate curves of flexural stiffness, deformation and crack propagation. The crack propagation rate exhibited two distinct regions when plotted on a log scale, namely the small-crack growth region and the long-crack growth region. The small-crack growth region for the studied rock-concrete interfaces was not particularly pronounced. The long-crack growth region was the Paris’ law region and included both the acceleration and part of the deceleration stages. Based on the experimental results, the fatigue crack propagation rate in the Paris’ law region was then described using the empirical Paris’ law. The exponent m1 in the Paris’ law was found to be approximately constant, with a value of m1 ≈ 21 for the rock-concrete interface. The pre-factor C1 was found to be dependent on both the load ratio R and the type of the rock-concrete interface (represented by an elastic mismatch parameter α). By introducing R and α into the empirical Paris’ law, an adjusted Paris’ law was proposed. The adjusted Paris’ law can describe the fatigue crack propagation rate in a unified way for the same rock-concrete interface of different R and different interfaces in the scope of this research. Based on the adjusted Paris’ law, the fatigue cycles during the crack propagation and fatigue lifetimes of all tested rock-concrete interface specimens were reasonably predicted. For practical applications, an approach was suggested involving a combination of the adjusted Paris’ law and a material coefficient β (approximately β ≈ 0.143 in this study) to estimate the fatigue lifetimes of structures or specimens with existing pre-cracks at the rock-concrete interface.

Transformation of Bima local wisdom values through social studies e-book media

The development of postmodern-era technology in the world of education is increasingly sophisticated, thus impacting the character of students and their social environment. Technological progress negatively affects the lives of today's generation. When misuse of technology is widespread, it is imperative to strengthen cultural and religious filtration. So that the influence of globalization on technological development can be minimized. So as not to damage the cultural values and morality of students as the next generation of the nation. This study aims to explain the importance of transforming the values of Bima's local wisdom "Nggusu Waru" through the media of social studies e-books. The results and conclusions of this study are efforts to develop students' social character that require teacher collaboration, supervision, and optimal parental attention so that their interest in learning is higher and minimizes deviant behavior. This research method uses research and development design. At the stage of preliminary studies with models developed by Borg and Gall. Through several stages of research, information gathering, development of initial forms of products, and initial field testing. In this step, data is collected through interviews, observation and documentation. The data is analyzed to find out some of its weaknesses and shortcomings.

Test suite optimization under multi-objective constraints for software fault detection and localization: Hybrid optimization based model

Testing and debugging have been the most significant steps of software development since it is tricky for engineers to create error-free software. Software testing takes place after coding with the goal of finding flaws. If errors are found, debugging would be done to identify the source of the errors so that they may be fixed. Detecting as well as locating defects are thus two essential stages in the creation of software. We have created a unique approach with the following two working phases to generate a minimized test suite that is capable of both detecting and localizing faults. In the initial test suite minimization process, the cases were generated and minimized based on the objectives such as D-score and coverage by the utilization of the proposed Blue Monkey Customized Black Widow (BMCBW) algorithm. After this test suite minimization, the fault validation is done which includes the process of fault detection and localization. For this fault validation, we have utilized an improved Long Short-Term Memory (LSTM). At 90% of the learning rate the accuracy of the presented work is 0.97%, 2.20%, 2.52%, 0.97% and 2.81% is better than the other extant models like AOA, COOT, BES, BMO and BWO methods. The results obtained proved that our Blue Monkey Customized Black Widow Optimization-based fault detection and localization approach can provide superior outcomes.

Structural changes of flaxseed protein modified by fermentation and the gel properties and swallowing characteristics of its composite system with mung bean starch

The fermentation modification of plant-based proteins has attracted extensive attention recently. This study was to investigate the effect of fermentation on molecular structures of flaxseed protein (FP), and evaluate the gel properties and swallowing characteristics of the composite gel composed of mung bean starch (MBS) and fermented FP (FFP). After 10 h of fermentation, the content of free amino acids in FFP increased ∼14.3 times over that of the unfermented FP, while the proportion of small peptides increased by ∼37.2%. Fermentation reduced the α-helical conformation in FFP. After heating, FFP was easier to cross-link with MBS to form strengthened composite gel network with denser and larger pores as well as thicker pore wall, in which the maximum gel hardness increased by 2.6 times. MBS-FFP composite gels also exhibited increase in viscoelastic moduli, cohesiveness, thermal stability, and water-holding capacity (WHC) than the control gel. The WHC was increased from 63.4% to 92.3% when composite gel contained 10 h fermented FP. Furthermore, international dysphagia diet standardization initiative (IDDSI) tests indicated that all MBS-FFP composite gels could be categorized as level 7 dysphagia food. These findings provide new insights into the structural nature and potential application of plant protein-based fermentation-induced gel systems.

Microfluidic preparation of surfactant-free ultrafine DAAF with tunable particle size for insensitive initiator explosives

High purity and ultrafine DAAF (u-DAAF) is an emerging insensitive charge in initiators. Although there are many ways to obtain u-DAAF, developing a preparation method with stable operation, accurate control, good quality consistency, equipment miniaturization, and minimum manpower is an inevitable requirement to adapt to the current social technology development trend. Here reported is the microfluidic preparation of u-DAAF with tunable particle size by a passive swirling microreactor. Under the guidance of recrystallization growth kinetics and mixing behavior of fluids in the swirling microreactor, the key parameters (liquid flow rate, explosive concentration and crystallization temperature) were screened and optimized through screening experiments. Under the condition that no surfactant is added and only experimental parameters are controlled, the particle size of recrystallized DAAF can be adjusted from 98 nm to 785 nm, and the corresponding specific surface area is 8.45 m2·g-1 to 1.33 m2·g-1. In addition, the preparation method has good batch stability, high yield (90.8% to 92.6%) and high purity (99.0% to 99.4%), indicating a high practical application potential. Electric explosion derived flyer initiation tests demonstrate that the u-DAAF shows an initiation sensitivity much lower than that of the raw DAAF, and comparable to that of the refined DAAF by conventional spraying crystallization method. This study provides an efficient method to fabricate u-DAAF with narrow particle size distribution and high reproducibility as well as a theoretical reference for fabrication of other ultrafine explosives.

La eficacia del Escape Room como metodología educativa en el Código Infarto

ObjectiveTo evaluate the efficacy of an educational intervention (escape room) in the acquisition and retention of knowledge in relation to the Infarction Code, and to compare the knowledge of other teaching methodologies related to the Infarction Code. MethodsA pre-post study was designed without a control group. After one month of the master class on the Infarction Code given to master's degree (doctors and nurses), an educational intervention was carried out consisting of an Escape Room on the same content, with a questionnaire that collected various sociodemographic data, and a knowledge test on the Infarction Code, which was repeated immediately after the activity and at the end of 2 months after the activity, and a test of knowledge on the Infarction Code. immediately after the activity and 2 months after the master class. Likewise, after the activity, a gamified experience evaluation questionnaire (GAMEX) was completed. ResultsThirty-two students received the educational intervention (12 physicians and 20 nurses), and differences were observed between medical and nursing professionals in terms of initial knowledge of simulation and gamification. After the activity, and based on the initial knowledge test, the score increased by 3.49 points, an increase that was also reflected in the test taken two months after the master class, where an increase of 2.08 points was maintained. The participants rated the experience positively, with no significant overall differences between the two professional groups. ConclusionsThe nurses had greater knowledge and contact with clinical simulation, virtual reality and gamification. The escape room showed to be a valid method for the assimilation and retention of knowledge in master's degree students. Medical professionals experienced a greater degree of immersion in the activity.

Assessment of Local Radial Basis Function Collocation Method for Diffusion Problems Structured with Multiquadrics and Polyharmonic Splines

This paper aims to systematically assess the local radial basis function collocation method, structured with multiquadrics (MQs) and polyharmonic splines (PHSs), for solving steady and transient diffusion problems. The boundary value test involves a rectangle with Dirichlet, Neuman, and Robin boundary conditions, and the initial value test is associated with the Dirichlet jump problem on a square. The spectra of the free parameters of the method, i.e., node density, timestep, shape parameter, etc., are analyzed in terms of the average error. It is found that the use of MQs is less stable compared to PHSs for irregular node arrangements. For MQs, the most suitable shape parameter is determined for multiple cases. The relationship of the shape parameter with the total number of nodes, average error, node scattering factor, and the number of nodes in the local subdomain is also provided. For regular node arrangements, MQs produce slightly more accurate results, while for irregular node arrangements, PHSs provide higher accuracy than MQs. PHSs are recommended for use in diffusion problems that require irregular node spacing.

Carboxymethylcellulose-induced depletion attraction to stabilize high internal phase Pickering emulsions for the elderly: 3D printing and β-carotene delivery

In this study, a carboxymethylcellulose (CMC) induced depletion attraction was developed to stabilize high internal phase Pickering emulsions (HIPPEs) as age-friendly 3D printing inks. The results demonstrated that depletion force induced the adsorption of yolk particles at the droplet interface and the formation of osmotic droplet clusters, thereby increasing the stability of HIPPEs. In addition, the rheological properties and nutrient delivery properties of HIPPEs could be adjusted by the mass ratio of yolk/CMC. The HIPPEs stabilized at yolk/CMC mass ratio 20:7.5 showed optimal printability, viscoelastic, structural recovery, and swallowability. HIPPEs have been applied to 3D printing, International Dysphagia Dietary Standardization Initiative (IDDSI) test, and in vitro digestive simulation in the elderly, indicating their attractive appearance, safe swallowability, and enhanced bioaccessibility of β-carotene. Our work provides new ideas for developing age-friendly foods with plasticity and nutrient delivery capacity by depletion attraction stabilizing HIPPEs.

Determining the Changes in Law Enforcement Recruit Aerobic Fitness Using the 2.4-km Run and 20-m Multistage Fitness Test. Does the Type of Test Matter?

Campbell, P, Maupin, D, Lockie, RG, Dawes, JJ, Simas, V, Canetti, E, Schram, B, and Orr, R. Determining the changes in law enforcement recruit aerobic fitness using the 2.4-km run and 20-m multistage fitness test. Does the type of test matter? J Strength Cond Res 38(6): 1111-1117, 2024-Aerobic fitness is linked with academy graduation, employment, and the long-term health of law enforcement officers and is often used as a training outcome. However, different tests can be used, and aerobic improvements may differ according to the test used. The aim of this study was to determine whether recruits improved to a greater extent in 1 aerobic test compared with the other. Retrospective data from 5 law enforcement recruit cohorts (males = 741; females = 353) who underwent 18 weeks of academy training were analyzed. Initial 20-m multistage fitness test (20MSFT) and 2.4-km run assessments were completed during weeks 4 and 5 of training, with final testing completed during weeks 16 and 17, respectively. A repeated-measures analysis of variance ( p < 0.05) with a Bonferroni post hoc analysis determined changes in aerobic fitness in the 20MSFT and 2.4-km run between male and female recruits. A mean difference of 9.27 (95% confidence intervals [CI] 14.8-10.9; d = 0.63; p < 0.001) shuttle increase in 20MSFT performance and 20.1 (95% CI 16.0-24.2; d = 0.49; p < 0.001) second improvement in 2.4-km run time were demonstrated when averaged across sex, yielding a larger performance improvement for the 20MSFT compared with the 2.4-km run. Conversely, there was a smaller magnitude of change in aerobic fitness between male recruits and female recruits for the 20MSFT ( d = 0.47) compared with the 2.4-km run ( d = 0.50). The findings indicate that current academy training results in improvements to aerobic fitness and to a greater magnitude in the 20MSFT compared with the 2.4-km run. These results may affect policy considerations for law enforcement agencies regarding aerobic test selection.

Proficiency Testing Program for Fly Ash: Ensuring Quality and Consistency Through Standardized Evaluation

This case study evaluates a Proficiency Testing Program (PTP) for fly ash testing, focusing on the homogeneity, stability, and performance of participating laboratories. The study aims to identify areas for improvement in testing methodologies to enhance the reliability of fly ash analysis. The PTP adheres to international standards, including ISO 13528:2015 and ISO/IEC 17043:2010, for sample preparation, testing, and data analysis. The PTP ensures the homogeneity of test samples through meticulous division, testing, and data-driven analysis. The stability of samples is monitored through regular tests at predetermined intervals, with results compared to initial homogeneity tests. The methodology of evaluation involves calculating Z&amp;apos; (z-prime) scores to assess the performance of participant laboratories, with scores within ±2.0 considered satisfactory and scores beyond ±3.0 considered outliers. The results of the proficiency testing reveal variations in the performance of participant laboratories across specific gravity, fineness, compressive strength at 7 days, and soundness by autoclave parameters. While most laboratories demonstrate adherence to expected values, some deviations raise concerns and highlight the need for continuous improvement. Laboratories with deviations are encouraged to evaluate their testing methodologies and address factors contributing to the observed deviations. Overall, the study underscores the importance of proficiency testing in ensuring the quality and consistency of fly ash testing. Continued development and refinement of proficiency testing programs are essential for the sustainable utilization of fly ash in various applications.

Sustainable and economical alternatives to fragment capture materials in explosive and ballistic trials.

Strawboard has been utilised as a fragmentation capture material since the 1960s, mainly employed to capture fragments from explosives and explosive devices from arena trials of munitions. As this material has historically been calibrated to a known standard, it has a proven record of allowing research establishments to ascertain the velocity of a fragment based on the depth of penetration of the strawboard. During the time of calibration, strawboard was used as a common building material which was both widely available and relatively affordable; however, due to the recent economic crisis and geopolitical supply issues, this is no longer the case. Building on initial testing, this paper investigates alternatives to strawboard to determine if a cheaper, more readily available material can be used instead. The alternatives are compared and judged based on the NATO ARSP-03 guideline for capture material which includes metrics such as price and attainability, as well as assessing environmental impact and its ability to be used as a viable alternative to strawboard in an explosive environment. Based on these NATO guidelines, explosive fragmentation and ballistic experiments were conducted, and ten materials were tested based on the following criteria: Handling, Density, Flammability, Calibration, Cost and Availability. Medium Density Fibreboard (MDF) was found to be a suitable alternative to strawboard. The data demonstrates that it provides the same capture performance as strawboard at approximately a quarter of the cost and is far more readily available. Other materials also showed potential and further testing should be undertaken to validate these materials as alternatives to MDF.

In-situ analysis of SCC initiation on Alloy 600 surface in primary water environment using digital image correlation with electron backscatter diffraction

This study examined the stress corrosion cracking (SCC) phenomenon of Alloy 600 in a high-temperature primary water environment. The investigation involved the observation of local plastic deformation and SCC initiation on the specimen surface using an observation apparatus, comprising a laser confocal microscope (LCM) and an autoclave equipped with a diamond window view-port. Prior to conducting the SCC initiation test, the crystalline structure of the specimen, including grain boundary (GB) characteristics, Schmid factor, and trace inclination angle, underwent examination using an electron backscatter diffraction (EBSD) technique. The local strain distribution was subsequently analyzed using a digital image correlation (DIC) method, employing LCM images obtained during the SCC experiments. The ex-situ EBSD analysis indicated that SCC mainly initiated at random high-angle grain boundaries (HAGB) with trace inclination angles close to 90° relative to the tensile axis. DIC analysis further revealed that most GBs in the vicinity of the highly strained area cracked among random HAGBs with a high trace inclination angle to the tensile axis. This confirms that the local strain gradient at GBs plays an important role in SCC initiation, serving as a more suitable indicator of an additional stress component to effective normal stress acting on GBs compared to the Schmid factor mismatch.

PENGUJIAN KINERJA WEB SERVER ELASTIC CLOUD COMPUTE (EC2) FREE TIER PADA AMAZON WEB SERVICE (AWS) MENGGUNAKAN JMETER

The research aims to evaluate the capacity of Amazon Web Service's (AWS) Elastic Cloud Compute (EC2) Free Tier Web Server using the JMeter testing tool. The objective is to ascertain the extent of the server's load-bearing capabilities. Tests were conducted, loading 500 users within a 10-second range and 1000 users within a 1-second range. Despite being a free service, test results showed the server's capability to handle high loads without errors (0% error rate). These findings illustrate the free service's ability to maintain stable performance under significant user loads. The utilization of EC2 Free Tier on AWS demonstrates its capacity to handle heavy tasks without compromising service quality. From about 5 steps in each of two tests, the value for sample time / response time in the initial test of the Amazon Web Service Web server is 59 / ms (millisecond) and the average latency value in the second test, namely 7.213 /ms (millisecond). Both of these gained CPU Utilization from minum, average and maximum with final rate are zero Error. This outcome concludes that the free server possesses robust and reliable capabilities, instilling confidence in an effective and efficient server solution even under high usage levels without additional costs.

Surface Heat Monitoring with High-Resolution UAV Thermal Imaging: Assessing Accuracy and Applications in Urban Environments

The urban heat island (UHI) effect, where urban areas experience higher temperatures than surrounding rural regions, necessitates effective monitoring to estimate and address its diverse impacts. Many existing studies on urban heat dynamics rely on satellite data with coarse resolutions, posing challenges in analyzing heterogeneous urban surfaces. Unmanned aerial vehicles (UAVs) offer a solution by providing thermal imagery at a resolution finer than 1 m. Despite UAV thermal imaging being extensively explored in agriculture, its application in urban environments, specifically for surface temperatures, remains underexplored. A pilot project conducted in Athens, Georgia, utilized a UAV with a FLIR Vue Pro R 640 thermal camera to collect thermal data from two neighborhoods. Ground data, obtained using a handheld FLIR E6-XT infrared imaging camera, were compared with UAV thermal imagery. The study aimed to assess the accuracy of the UAV camera and the handheld camera for urban monitoring. Initial testing revealed the handheld’s accuracy but tendency to underpredict, while UAV camera testing highlighted considerations for altitude in both the rjpg and tiff image pixel conversion models. Despite challenges, the study demonstrates the potential of UAV-derived thermal data for monitoring urban surface temperatures, emphasizing the need for careful model considerations in data interpretation.

Attitudes toward the American Cancer Society's 2020 cervical cancer screening guidelines: A qualitative study of a national sample of US clinicians.

The 2020 American Cancer Society (ACS) guidelines are the most recent national guidelines for cervical cancer screening. These guidelines propose two major changes from current practice: initiating screening at age 25 years and using primary human papillomavirus (HPV) testing. Adoption of guidelines often occurs slowly, and therefore understanding clinician attitudes is important to facilitate practice change. Interviews with a national sample of clinicians who perform cervical cancer screening in a variety of settings explored attitudes toward the two major changes from the 2020 ACS cervical cancer screening guidelines. Clinicians participated in 30- to 60-min interviews exploring their attitudes toward various aspects of cervical cancer screening. Qualitative analysis was performed. Seventy clinicians participated from across the United States. Few respondents were initiating screening at age 25 years, and none were using primary HPV testing. However, over half would be willing to adopt these practices if supported by scientific evidence and recommended by professional medical organizations. Barriers to adoption included the lack of endorsement by professional societies, lack of laboratory availability and insurance coverage, limited autonomy within large health care systems, and concerns related to missed disease. Few clinicians have adopted screening initiation or primary HPV testing, as recommended by the 2020 ACS guidelines, but over half were open to adopting these changes. Implementation may be facilitated via professional organization endorsement, clinician education, and laboratory, health care system, and insurance support. In 2020, the American Cancer Society (ACS) released updated guidelines for cervical cancer screening. The main changes to current practices were to initiate screening at age 25 years instead of age 21 years and to screen using primary human papillomavirus (HPV) testing rather than cytology alone or in combination with HPV testing. We performed in-depth interviews with 70 obstetrics and gynecology, family medicine, and internal medicine physicians and advanced practice providers about their attitudes toward these guidelines. Few clinicians are following the 2020 ACS guidelines, but over half were open to changing practice if the changes were supported by evidence and recommended by professional medicalorganizations. Barriers to adoption included the lack of endorsement by professional medical organizations, logistical issues, and concerns about missed disease.

Usefulness of serial testing for the diagnosis of malaria in cases of fever upon return from travel.

When malaria is suspected in case of fever after travel in endemic areas, the current recommendation is to repeat the malaria test at 24-hour intervals, with up to two additional tests, as long as the test result is negative. A retrospective analysis was conducted to investigate the appropriateness of this recommendation by determining the proportion of tests with negative result at first and subsequently with a positive one at second or third attempt. A retrospective study was conducted at the Centre for Primary Care and Public Health, Lausanne, covering a period of 15years. All patients tested once for malaria were included. Testing included microscopy thick and thin films as well as malaria rapid diagnostic test used in combination. The main outcome measure was the proportion of patients with a first negative test result, subsequently positive on second or third test over the total patients with suspected malaria assessed. Demographic, travel, clinical, and laboratory variables were collected from patients' records to identify potential predictors of an initially negative and then positive test result. Four thousand nine hundred seventy-two patients were included. Of those, 4557 (91.7%) had definitive negative test results, and 415 (8.3%) had a positive result on the first test [332/415 (80%) Plasmodium falciparum, 40/415 (9.6%) P. vivax, 21/415 (5.1%) P. ovale, 12/415 (2.9%) P. vivax/ovale, 9/415 (2.2%) P. malariae and 1/415 (0.2%) P. knowlesi], and 3/4972 (0.06%) had a positive result on the second test after a first negative result, 1/4972(0.02%) had a positive test result after 2 negative results, all with P. falciparum. One of the four patients that were positive after their initial negative test was pregnant. The very small number of patients with an initially negative test result and secondarily positive did not allow for risk factor analysis. The current recommendation of serial malaria testing is not supported by the present study, a fortiori for those who do not present with a strong clinical or laboratory predictor of malaria.

Artificial Intelligence in the Diagnosis of Colorectal Cancer: A Literature Review.

The aim of this review is to explore the role of artificial intelligence in the diagnosis of colorectal cancer, how it impacts CRC morbidity and mortality, and why its role in clinical medicine is limited. A targeted, non-systematic review of the published literature relating to colorectal cancer diagnosis was performed with PubMed databases that were scouted to help provide a more defined understanding of the recent advances regarding artificial intelligence and their impact on colorectal-related morbidity and mortality. Articles were included if deemed relevant and including information associated with the keywords. The advancements in artificial intelligence have been significant in facilitating an earlier diagnosis of CRC. In this review, we focused on evaluating genomic biomarkers, the integration of instruments with artificial intelligence, MR and hyperspectral imaging, and the architecture of neural networks. We found that these neural networks seem practical and yield positive results in initial testing. Furthermore, we explored the use of deep-learning-based majority voting methods, such as bag of words and PAHLI, in improving diagnostic accuracy in colorectal cancer detection. Alongside this, the autonomous and expansive learning ability of artificial intelligence, coupled with its ability to extract increasingly complex features from images or videos without human reliance, highlight its impact in the diagnostic sector. Despite this, as most of the research involves a small sample of patients, a diversification of patient data is needed to enhance cohort stratification for a more sensitive and specific neural model. We also examined the successful application of artificial intelligence in predicting microsatellite instability, showcasing its potential in stratifying patients for targeted therapies. Since its commencement in colorectal cancer, artificial intelligence has revealed a multitude of functionalities and augmentations in the diagnostic sector of CRC. Given its early implementation, its clinical application remains a fair way away, but with steady research dedicated to improving neural architecture and expanding its applicational range, there is hope that these advanced neural software could directly impact the early diagnosis of CRC. The true promise of artificial intelligence, extending beyond the medical sector, lies in its potential to significantly influence the future landscape of CRC's morbidity and mortality.

Smartphone-Facilitated In-Situ Hearing Aid Audiometry for Community-Based Hearing Testing.

Hearing loss prevalence is increasing, with an estimated 2.5 billion people affected globally by 2050. Scalable service delivery models using innovative technologies and task-shifting are World Health Organization priorities to improve access to hearing care, particularly in low- and middle-income countries. Smartphone-facilitated audiometry in the community using hearing aids covered by noise-attenuating ear cups ("in-situ") could support more accessible hearing care when provided by less trained individuals such as community health workers (CHWs). This study aimed to determine the validity of this method for potential hearing aid fitting. Study objectives included determining the maximum permissible ambient noise level (MPANL), inter-device reliability, clinical threshold accuracy, reliability, and performance in real-world settings. Experiment 1: 15 normal-hearing adult participants were evaluated to determine MPANLs for circumaural Peltor 3M earcups covering Lexie Lumen hearing aids with smartphone-facilitated in-situ audiometry. MPANLs were calculated by measuring the difference in attenuation between thresholds obtained with standard headphones and in-situ hearing aids. Experiment 2: Pure-tone frequency and intensity output of 14 same-model Lexie Lumen hearing aids were measured to determine inter-device reliability. Pure-tone stimuli were measured and analyzed to determine sound pressure levels in decibels and pure-tone frequency when connected to a test box 2cc coupler. Experiment 3: 85 adult participants were tested in a sound booth to determine the accuracy of automated in-situ pure-tone audiometry (PTA) compared to clinical PTA (500, 1000, 2000, 3000, 4000, 6000 Hz) facilitated by an audiologist. The first 39 participants were tested twice to determine test-retest reliability. Experiment 4: In a community setting, 144 adult participants were tested with automated in-situ audiometry facilitated by CHWs using a smartphone app. These participants were subsequently tested with automated mobile PTA (500, 1000, 2000, 4000 Hz). An additional 44 participants were tested twice to determine test-retest reliability. Experiment 1: MPANLs of the Peltor 3M earcup-covered hearing aids were higher than standard headphones across all frequencies, ranging from 24 to 47.3 dB SPL. Experiment 2: Inter-device performance reliability was high, with all inter-device differences across all intensities and frequencies less than 3 dB. Frequency output was consistent and differed less than 0.7% between devices. Experiments 3 and 4: 85.2% and 83.3% of automated in-situ audiometry thresholds were within 10 dB of thresholds obtained in the sound booth and in a community setting, respectively. Acceptable test-retest intraclass correlation coefficient (ICC) was evident across all thresholds obtained in a sound booth (ICC = 0.85 to 0.93) and in a community setting (ICC = 0.83 to 0.97). Smartphone-facilitated in-situ audiometry allows for reliable and valid community-based testing. A simple smartphone user interface and automated in-situ audiometry allow CHWs with minimal training to facilitate the testing. With the additional capability to program hearing aids via the smartphone after the initial test, this approach would have the potential to support widespread access to personalized hearing aid fittings facilitated by CHWs in low- and middle-income countries. This approach also supports self-fitting options based on in-situ thresholds, enabling testing and fitting via over the counter hearing aids.

Mothers' Perceived Co-Parenting and Preschooler's Problem Behaviors: The Mediating Role of Maternal Parenting Stress and the Moderating Role of Family Resilience.

Problem behaviors in preschoolers signals social adjustment challenges. This study investigates the mediating role of parenting stress in the relationship between co-parenting and these behaviors, and examines how family resilience impacts this dynamic. A detailed survey was conducted with 1279 mothers of 3-6-year-olds in Shanghai, China, focusing on co-parenting, family resilience, parenting stress, and children's behaviors. We employed SPSS 26 for initial tests and the Hayes PROCESS macro in SPSS 23.0 for advanced analysis, using bootstrap methods to assess mediation and moderation effects. The analysis revealed that maternal parenting stress mediates the relationship between co-parenting and children's problem behaviors. Specifically, unsupportive co-parenting or low levels of supportive co-parenting heightened maternal stress, which in turn increased children's problem behaviors. Family resilience was found to moderate this relationship, buffering the impact of unsupportive co-parenting on maternal stress. High family resilience levels were associated with lower parenting stress, regardless of co-parenting quality. These findings highlight the importance of enhancing family resilience and supportive co-parenting to mitigate parenting stress and reduce problem behaviors in children. It has practical implications for developing family-centred interventions and policies to strengthen family resilience and co-parenting skills.