The study of the unsaturated soils is a very complex field to which several researches in laboratory and on site are directed these last years. An experimental study aims to quantify the influence of the Skempton coefficient B characterizing the degree of saturation on the behavior of the granular sand to the liquefaction resistance of sand. The study is based on undrained triaxial tests performed on natural Chlef sand carried out at an initial relative density Dr = 50% under a confining pressure of 50, 100 and 200 kPa for Skempton coefficient B = 10 to 92%. The results of the tests show that an increase of confining pressure leads to an increase of the shear stress of the samples. For the lower value of the degree of saturation results of our findings indicate an increase of the resistance to liquefaction; our results are in good agreement with others observed in several research projects conducted with other sands. The increase of Skempton coefficient B induces an increase of pore water pressure and a decrease of the shear strength. The pore pressure (u) increases with an exponential manner with the increase of the degree of saturation; while the residual shear strength (Rs) decreases with logarithmic manner with the increase of degree of saturation (B).