Initial Detachment Research Articles

Incidence and risk factors for macular oedema after primary rhegmatogenous retinal detachment surgery: a prospective single-centre study.

To assess the incidence of cystoid macular oedema (CME) diagnosed by spectral domain optical coherence tomography (SD-OCT) after primary rhegmatogenous retinal detachment (RRD) surgery. From April 2016 to October 2017, 150 eyes of 150 patients presenting with primary RRD were included consecutively in this prospective single-centre study. Patients with the following characteristics were excluded: previous vitreoretinal surgery, combined cataract surgery, preoperatively presentation with any intraocular or systemic inflammatory condition, visible macular oedema or epiretinal membrane (ERM) on funduscopy. SD-OCT (Spectralis, Heidelberg Engineering) was conducted 3 and 6 weeks after surgery. One hundred and twenty-eight of the 150 patients completed the study, of whom 107 (age: 61.7 ± 11.5 years, mean ± SD) showed successful retinal attachment during follow-up visits. The most frequent operation method was scleral buckling (54.2%), followed by vitrectomy (25.2%) and the combination of both techniques (20.6%). Postoperative SD-OCT revealed CME, neurosensory detachment and ERM in 18.7, 31.8 and 32.7% of all cases, respectively. The risk of postoperative CME was significantly elevated in patients with ERM (42.9 versus 6.9%, p < 0.001). In addition, patients with initial detachment of the macula had more postoperative CME (26.5 versus 11.1%, p = 0.044). BCVA improvement was significantly lower in patients with CME compared to patients without 6 weeks after surgery for macula-on RRD. This prospective study confirmed that postoperative CME is a frequent complication after RRD surgery; we identified ERM and macula-off RRD as potential risk factors. As CME potentially delays visual recovery, postoperative follow-ups should include SD-OCT.

De novo formation of early endosomes during Rab5-to-Rab7a transition.

ABSTRACTRab5 and Rab7a are the main determinants of early and late endosomes and are important regulators of endosomal progression. The transport from early endosomes to late endosome seems to be regulated through an endosomal maturation switch, where Rab5 is gradually exchanged by Rab7a on the same endosome. Here, we provide new insight into the mechanism of endosomal maturation, for which we have discovered a stepwise Rab5 detachment, sequentially regulated by Rab7a. The initial detachment of Rab5 is Rab7a independent and demonstrates a diffusion-like first-phase exchange between the cytosol and the endosomal membrane, and a second phase, in which Rab5 converges into specific domains that detach as a Rab5 indigenous endosome. Consequently, we show that early endosomal maturation regulated through the Rab5-to-Rab7a switch induces the formation of new fully functional Rab5-positive early endosomes. Progression through stepwise early endosomal maturation regulates the direction of transport and, concomitantly, the homeostasis of early endosomes.

Thermal Reversal Surface with “Sticky Tentacle” for Modulating Initial Cell Adhesion and Detachment

Thermal responsive polymers were introduced for effectively cell detachment from the extracellular matrix (ECM), where the poor cell adhesive capacity was improved by the immobilized biodhesion molecules (most are proteins) at the termini of grafted polymer. However, this protein-mediated adhesion makes it hard to be precisely controlled and takes longer time to start initial cell attachment. Here we describe a choline phosphate(CP) modified thermal responsive surface with enhanced initial cell adhesion based on multivalent CP-PC (phosphatidyl choline, the head-group of phospholipids in all the eukaryotic cell membranes) interaction. The well-defined functional surfaces were constructed using surface-initiated ATRP and click reaction, where the initial cell attachment reach saturation in 10 min and can be regulated by CP density on the surface. Consequently, the fast cell adhesion significantly accelerates cell spreading and proliferation. The facile cell harvest, as opposed to the original mechanism of thermally-induced cell detachment, is to take advantage of the thermal contraction of the polymer above the LCST, which release the adherent cell by reducing the accessibility of the CP groups to cell membrane PC lipids. Si-CP is expected to provide a promising universal structural model for modulating cell attachment and detachment in tissue engineering and regenerative medicine field.

Numerical Simulation of Single-Droplet Dynamics, Vaporization, and Heat Transfer from Impingement onto Static and Vibrating Surfaces

A numerical study is presented to examine the behavior of a single liquid droplet initially passing through air or steam, followed by impingement onto a static or vibrating surface. The fluid dynamic equations are solved using the Volume of Fluid method, which includes both viscous and surface tension effects, and the possibility of droplet evaporation when the impact surface is hot. Initially, dynamic behavior is examined for isothermal impingement of a droplet moving through air, first without and then with boundary vibration. Isothermal simulations are used to establish how droplet rebound conditions and the time interval between initial contact to detachment vary with droplet diameter for droplet impingement onto a stationary boundary. Heat transfer is then assessed for a liquid droplet initially at saturation temperature passing through steam, followed by contact with a hot vibrating boundary, in which droplet evaporation commences. The paper shows that, for droplet impingement onto a static boundary, the minimum impact velocity for rebound reduces linearly with droplet diameter, whereas the time interval between initial contact and detachment appears to increase linearly with droplet diameter. With the introduction of a vibrating surface, the minimum relative impact velocity for isothermal rebound is found to be higher than the minimum impact velocity for static boundary droplet rebound. For impingement onto a hot surface, in which droplet evaporation commences, it is shown that large-amplitude surface vibration reduces heat transfer, whereas low-amplitude high-frequency vibration appears to increase heat transfer.

Inhibition of Virulence Factors and Biofilm Formation of Acinetobacter Baumannii by Naturally-derived and Synthetic Drugs.

Acinetobacter baumannii is a gram-negative, aerobic, non-motile, and pleomorphic bacillus. A. baumannii is also a highly-infectious pathogen causing high mortality and morbidity rates in intensive care units. The discovery of novel agents against A. baumannii infections is urgently needed due to the emergence of drug-resistant A. baumannii strains and the limited number of efficacious antibiotics available for treatment. In addition to the production of several virulence factors, A. baumannii forms biofilms on the host cell surface as well. Formation of biofilms occurs through initial surface attachment, microcolony formation, biofilm maturation, and detachment stages, and is one of the major drug resistance mechanisms employed by A. baumannii. Several studies have previously reported the efficacy of naturally-derived and synthetic compounds as anti- biofilm and anti-virulence agents against A. baumannii. Here, inhibition of biofilm formation and virulence factors of A. baumannii using naturally-derived and synthetic compounds are reviewed.

Detachment, peer pressure, and age of first substance use as gateways to later substance use

BackgroundPrior research using psychosocial developmental models have identified emotional detachment from family and susceptibility to peer pressure as predictors of adolescent substance use. Despite mixed support for the gateway hypothesis, less is known about how these psychosocial developmental factors facilitate adolescent substance use. The purpose of this study was to examine how age of first substance use, emotional detachment from parents, and susceptibility to peer pressure influence the progression from alcohol, marijuana, and tobacco use to other illicit substance use (e.g., cocaine, hallucinogens). MethodData (N = 5792) were collected from high school students across seven semesters. Latent growth curve modeling was used to examine how age of first use of alcohol, marijuana, and tobacco predicted initial levels and changes in emotional detachment, peer pressure, and other illicit substance use. ResultsEarlier age of first use of alcohol, marijuana, and tobacco predicted detachment, peer pressure, and a greater likelihood of initial use of other illicit substances. More initial emotional detachment was associated with increases in other illicit substance use. Earlier ages of first use of alcohol, marijuana, and tobacco had indirect effects on initial use of other illicit substances through initial emotional detachment. ConclusionEmotional detachment from parents and peer pressure impact the likelihood of other illicit substance use across the high school years. Prevention programs may benefit by focusing on delaying the onset of first use of substance use and by preventing emotional detachment from parents and peer pressure.

On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?

Metastasis is the leading cause of death for cancer patients. During cancer progression, the initial detachment of cells from the primary tumor and the later colonization of a secondary organ are characterized as limiting steps for metastasis. Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are opposite dynamic multistep processes that enable these critical events in metastasis by altering the phenotype of cancer cells and improving their ability to migrate, invade and seed at distant organs. Among the molecular pathways that promote tumorigenesis in late-stage cancers, transforming growth factor-β (TGF-β) is described as an EMT master inducer by controlling different genes and proteins related to cytoskeleton assembly, cell-cell attachment and extracellular matrix remodeling. Still, despite the successful outcomes of different TGF-β pharmacological inhibitors in cell culture (in vitro) and animal models (in vivo), results in cancer clinical trials are poor or inconsistent at least, highlighting the existence of crucial components in human cancers that have not been properly explored. Here we review most recent findings to provide perspectives bridging the gap between on-target anti-TGF-β therapies in vitro and in pre-clinical models and the poor clinical outcomes in treating cancer patients. Specifically, we focus on (i) the dual roles of TGF-β signaling in cancer metastasis; (ii) dynamic signaling; (iii) functional differences of TGF-β free in solution vs. in exosomes; (iv) the regulatory effects of tumor microenvironment (TME) – particularly by cancer-associated fibroblasts – on TGF-β signaling pathway. Clearly identifying and establishing those missing links may provide strategies to revitalize and clinically improve the efficacy of TGF-β targeted therapies.

20-year assessment of metastatic latency and subsequent time to death after proton therapy for uveal melanomas.

The aim of this study was to evaluate metastatic latency and survival after the occurrence of metastases in patients with choroidal/ciliary body melanoma treated with proton therapy. This was a retrospective cohort study. All consecutive patients with choroidal/ciliary body melanoma treated with proton therapy between 1991 and 2010 were included. Overall survival, specific survival (SS), local recurrence-free interval, and metastasis-free interval (MFI) were calculated. There were 508 patients. The mean follow-up was 239.4 months. Overall survival and SS rates were 57.2 and 67.6% at 10 years. Pre-equatorial tumor location, advanced tumor stage, and initial exudative retinal detachment were associated independently with SS. Thirty-three percent of the patients (n = 169) had metastases. Local recurrence-free interval and MFI were 91.3 and 65.7% at 10 years, respectively. MFI was shorter in pre-equatorial, large tumors, and/or tumors with exudative retinal detachment. After the occurrence of metastases, the median survival time was 1.25 years and survival probabilities were 62.1% at 1 year, 26.0% at 2 years, and 6.0% at 5 years. Except for age, none of the baseline clinical factors was associated with survival after metastasis occurrence. SS after metastasis occurrence was longer for metastasis occurring more than 10 years after tumor diagnosis (P =0.010). Death after metastasis is independent of initial tumor characteristics. Small tumors still have a risk for metastases after 10 years. Thus, lifelong follow-up is necessary for uveal melanoma patients. Larger series of metastatic patients are needed to evaluate aggressive multimodal treatments of metastases. Death after metastasis is independent of the initial tumor characteristics. Small tumors contraintuitively have a long-life risk of metastases. MFI is associated independently with pre-equatorial location, tumor stage, and retinal detachment.

What drives large-scale glacier detachments? Insights from Flat Creek glacier, St. Elias Mountains, Alaska

Abstract Two large-scale glacier detachments occurred at the peaks of the 2013 and 2015 CE melt seasons, releasing a cumulative 24.4–31.3 × 106 m3 of ice and lithic material from Flat Creek glacier, St. Elias Mountains, Alaska. Both events produced highly mobile and destructive flows with runout distances of more than 11 km. Our results suggest that four main factors led to the initial detachment in 2013: abnormally high meltwater input, an easily erodible glacier bed, inefficient subglacial drainage due to a cold-ice tongue, and increased driving stresses stemming from an internal redistribution of ice after 2011. Under a drastically altered stress regime, the stability of the glacier remained sensitive to water inputs thereafter, culminating in a second detachment in 2015. The similarities with two large detachments in the Aru mountains of Tibet suggest that these detachments were caused by a common mechanism, driven by unusually high meltwater inputs. As meltwater production increases with rising temperatures, the possible increase in frequency of glacier detachments has direct implications for risk management in glaciated regions.

Impact of Disdrometer Types on Rainfall Erosivity Estimation

Soil erosion by water is affected by the rainfall erosivity, which controls the initial detachment and mobilization of soil particles. Rainfall erosivity is expressed through the rainfall intensity (I) and the rainfall kinetic energy (KE). KE–I relationships are an important tool for rainfall erosivity estimation, when direct measurement of KE is not possible. However, the rainfall erosivity estimation varies depending on the chosen KE–I relationship, as the development of KE–I relationships is affected by the measurement method, geographical rainfall patterns and data handling. This study investigated how the development of KE–I relationships and rainfall erosivity estimation is affected by the use of different disdrometer types. Rainfall data were collected in 1-min intervals from six optical disdrometers at three measurement sites in Austria, one site in Czech Republic and one site in New Zealand. The disdrometers included two disdrometers of each of the following types: the PWS100 Present Weather Sensor from Campbell Scientific, the Laser Precipitation Monitor from Thies Clima and the first generation Parsivel from OTT Hydromet. The fit of KE–I relationships from the literature varied among disdrometers and sites. Drop size and velocity distributions and developed KE–I relationships were device-specific and showed similarities for disdrometers of the same type across measurement sites. This hindered direct comparison of results from different types of disdrometers, even when placed at the same site. Thus, to discern spatial differences in rainfall characteristics the same type of measurement instrument should be used.

Surgical rehabilitation of terror-related open globe injuries in the Turkish Military: long-term results

IntroductionThe purpose of this study is to evaluate the factors affecting multiple surgeries, worse visual outcome, eye removal (ER) and vitrectomy requirement in terror-related open-globe injuries (OGI) in the Turkish...

The ArfGAP Drongo Promotes Actomyosin Contractility during Collective Cell Migration by Releasing Myosin Phosphatase from the Trailing Edge

Collective cell migration is involved in various developmental and pathological processes, including the dissemination of various cancer cells. During Drosophila melanogaster oogenesis, a group of cells called border cells migrate collectively toward the oocyte. Herein, we show that members of the Arf family of small GTPases and some of their regulators are required for normal border cell migration. Notably, we found that the ArfGAP Drongo and its GTPase-activating function are essential for the initial detachment of the border cell cluster from the basal lamina. We demonstrate through protein localization and genetic interactions that Drongo controls the localization of the myosin phosphatase in order to regulate myosin II activity at the back of the cluster. Moreover, we show that toward the class III Arf, Drongo acts antagonistically to the guanine exchange factor Steppke. Overall, our work describes a mechanistic pathway that promotes the local actomyosin contractility necessary for border cell detachment.

Fatty degeneration and wnt10b expression in the supraspinatus muscle after surgical repair of torn rotator cuff tendon.

In the torn rotator cuff muscles, decreased expression of wnt10b prior to elevation of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα) has previously been reported. The purpose of this study is to elucidate the expression profiles of these adipogenesis-related genes after rotator cuff detachment and reattachment in a rabbit model. We investigated gene expression profiles of PPARγ, C/EBPα, and wnt10b in different parts of rabbit supraspinatus (SSP) muscle after tendon detachment (n = 6 for each time point). In addition, we assessed expression of the same genes after SSP reattachment with different intervals from initial detachment (n = 6). Fatty degeneration of the SSP muscle was examined by Oil red-O staining. Gene expression profiles were examined by quantitative real-time polymerase chain reaction. After SSP detachment, Oil red-O-positive oil deposits increased after 3 weeks. In the SSP reattachment model, numerous Oil red-O-positive cells were present at 5-week reattachment, following 2- and 3-week detachment. PPARγ and C/EBPα messenger ribonucleic acid expression exhibited a significant increase at 2 and 3 weeks after SSP detachment and remained increased at 5-week reattachment after 2- and 3-week detachment. A decreased expression of wnt10b was observed from 1 week after SSP detachment. Expression of wnt10b was recovered not in the central area of the SSP muscle but in the periphery after reattachment. Adipogenic change was not observed when SSP tendon was reattached after 1-week detachment. These results may suggest that once the adipogenic transcription factors, PPARγ and C/EBPα, were elevated, repair surgery after rotator cuff tear could not prevent the emergence of fat in the SSP muscle.

Plot-based experimental study of raindrop detachment, interrill wash and erosion-limiting degree on a clayey loessal soil

Better understanding of raindrop detachment, interrill wash and erosion-limiting degree in interrill processes is critical for accurately modelling interrill erosion and implementing proper anti-erosion strategies. Simulated rainfall experiments were conducted on a clayey loessal soil at three rainfall intensities (42, 60 and 90 mm h−1), five slope gradients (7°, 10°, 15°, 20° and 25°) and rainfall duration of 40 min. Results showed that raindrop detachment rate initially decreased rapidly within a few minutes and then reached a relative steady state during rainfall. The initial and steady raindrop detachment rate increased with increased rainfall intensity. Interrill wash rate peaked early and then decreased to a relative constant rate during the rainfall. The initial, maximum and steady interrill wash rate increased with increased rainfall intensity and slope gradient. Erosion-limiting degree (ELD), defined as the ratio of interrill wash rate to raindrop detachment rate, ranged from 10.99% to 35.70% under experimental conditions, indicating that interrill erosion system was transport-limited. The ELD decreased with rainfall intensity and increased linearly (R2 = 0.90) with slope gradient. The higher the rainfall intensity, the stronger the transport-limiting in interrill erosion processes; the steeper the slope gradient, the weaker the transport-limiting in interrill erosion processes. Raindrop detachment is the dominant process in detaching soil particles, whereas interrill flow contributes to washing out detached sediments. The findings of this study, especially ELD, largely improved the understanding of interrill erosion processes.

In Vitro Measurement and Modeling of Platelet Adhesion on VWF-Coated Surfaces in Channel Flow

The process of platelet adhesion is initiated by glycoprotein (GP)Ib and GPIIbIIIa receptors on the platelet surface binding with von Willebrand factor on the vascular walls. This initial adhesion and detachment of a single platelet is a complex process that involves multiple bonds forming and breaking and is strongly influenced by the surrounding blood-flow environment. In addition to bond-level kinetics, external factors such as shear rate, hematocrit, and GPIb and GPIIbIIIa receptor densities have also been identified as influencing the platelet-level rate constants in separate studies, but this still leaves a gap in understanding between these two length scales. In this study, we investigate the fundamental relationship of the dynamics of platelet adhesion, including these interrelating factors, using a coherent strategy. We build a, to our knowledge, novel and computationally efficient multiscale model accounting for multibond kinetics and hydrodynamic effects due to the flow of a cellular suspension. The model predictions of platelet-level kinetics are verified by our microfluidic experiments, which systematically investigate the role of each external factor on platelet adhesion in an in vitro setting. We derive quantitative formulas describing how the rates of platelet adhesion, translocation, and detachment are defined by the molecular-level kinetic constants, the local platelet concentration near the reactive surface determined by red-blood-cell migration, the platelet effective reactive area due to its tumbling motion, and the platelet surface receptor density. Furthermore, if any of these aspects involved have abnormalities, e.g., in a disease condition, our findings also have clinical relevance in predicting the resulting change in the adhesion dynamics, which is essential to hemostasis and thrombosis.

Relationships between retinal break locations and the shapes of the detachments.

PurposeDetecting primary breaks and confirming detachment preoperatively are important. Lincoff stated that retinal detachments progress according to gravity; his law has become popular. We evaluated Lincoff’s law with a slight modification to determine whether it remains suitable for present cases independent of refractive error and previous cataract surgery.Patients and methodsGroup 1 included superior region detachments not exceeding the 12 o’clock midline; the original break was within 1 1/2 clock hours of the highest detachment border. Group 2 included shallow inferior detachment; the original break corresponded to the more spread side of the 6 o’clock midline. Group 3 detachments were beyond 12 o’clock; the original break was within a triangle with a 12 o’clock apex (A) or within 1 1/2 hours of 12 o’clock (B); (A) and (B) were stated in the original report. Another five classifications were applied for small numbers of detachments. Consecutive initial rhegmatogenous retinal detachment surgery patients were included; medical records and detachment charts were examined. Eyes were classified into categories and rates were calculated. Eyes that had never undergone previous cataract surgery besides those in which the macula remained attached were divided into groups at a −6 D cutoff (Groups 1, 2, and 3[B]); we compared groups in each category. We compared phakic eyes, pseudophakic eyes, and eyes ruptured at the posterior capsule (Groups 1, 2, and 3[B]).ResultsFinally, 747 eyes were categorized. In Groups 1, 2, 3(A), and 3(B), corresponding rates were 92, 86, 70, and 89%, respectively. Between the above and below −6 D groups, there was no significant difference in rate in any category. There were no significant differences between phakic, pseudophakic, and ruptured eyes.ConclusionLincoff’s law was suitable for the present cases and independent of refractive error and previous cataract surgery.

Mechanism of the photo-induced activation of Co[sbnd]C bond in methylcobalamin-dependent methionine synthase

Methylcobalamin (MeCbl)-dependent enzyme methionine synthase (MetH), plays a critical role in the catalysis of methyl group transfer from methyltetrahydrofolate (CH3-H4folate) to homocysteine. It often performs a side reaction to generate cob(II)alamin through photolysis of the organometallic CoC σ bond. A hybrid QM/MM method has been applied to explore the photochemistry of MeCbl-bound MetH. The photolytic properties of MeCbl inside MetH are mediated by its manifold of low-lying excited states. The corresponding potential energy surfaces (PESs) of the electronically excited S1 state has been constructed as a function of axial bond lengths to elucidate the mechanism of photo-induced activation of CoC bond inside the enzyme. The analysis of the S1 PES has revealed that the two different electronic states of the S1 PES, namely metal-to-ligand charge transfer (MLCT) and the ligand field (LF), are relevant to the photodissociation of the CoC bond. There are two possible pathways identified, Path A and Path B, that connect the MLCT to LF state that represent possible photodissociation mechanisms. In the case of MetH, one possible photodissociation pathway (Path B) was identified based on the energetics of the MLCT and LF states. The energetically accessible Path B involves the initial detachment of the Co-NIm bond followed by a subsequent displacement of the CoC bond prior to the formation of cob(II)alamin / CH3 radical pair (RP). The photochemical data of base-on MeCbl in solution was compared with the computed result of MeCbl-bound MetH to understand the effect of the enzymatic environment on the photolytic properties of MeCbl.

Activation and diffusion of ammonia borane hydrogen on gold tetramers

AbstractOne of the most serious candidates for safe storage of high hydrogen densities is ammonia borane, AB. Likewise, one of the most versatile catalysts known is gold in the form of atomic clusters. Taking these elements into account, in this work a density functional theory ‐based study about initial activation, detachment, and diffusion of ammonia borane hydrogen on gold tetramer, as a catalyst model, is developed. It was found that the total process is exergonic and that the hydrogen diffusion occurs with very low energy barriers. The process has a hydrogen detachment energy barrier lower than the one of the uncatalyzed AB, and that is easily overcome by the energy expelled in the previous stage of formation of the initial activated species. Additionally, all the process is assisted by the fluxionality of the gold cluster, and occurs via a unique catalytically activated initial species, which contains a three‐center simultaneous interaction at the catalytically activated zone.

Experimental results and temporal surrogate modeling of particulate organic carbon released during interrill erosion

Despite its temporal nature, the release of particulate organic carbon from soils during interrill erosion lacks high resolution description via experimental datasets and has not been analyzed and predicted with time series approaches that might be adopted research and application. Hence, current research approaches have produced limited success to describe the interrill process that temporally flushes particulate organic carbon off of landscapes and into waterways. Therefore, the goals of this work included three-fold innovative components and was to (i) perform rain simulation experiments and collect a comprehensive particulate organic carbon erosion dataset during erosion; (ii) utilize the dataset to describe particulate organic carbon release as a function of governing transport variables using a multivariate autoregressive model, which is argued as a versatile tool for description of temporal erosion and inclusion within predictive modeling structure; and (iii) to apply a laboratory-based surrogate approach to predict erosion release, in absence of rainfall simulation data, that is coupled with the temporal modeling methodology. Data from the rainfall simulation experiments was collected on agricultural field sites from soils of different textures, including silt and silt loam soils, and with a variety of tillage systems. The experimental datasets reflected both the initial non-equilibrium detachment process followed by near-equilibrium detachment later in the simulations associated with aggregate structure and fluid energy, with the more aggressive tillage systems exhibiting less time to reaching equilibrium. Thereafter runoff and fine sized soil particle release was utilized as predictive variables within autoregressive temporal modeling of the carbon detachment process. The applied variables predicted carbon release well (i.e. 95% of the carbon loss was predicted) and notably both the non-equilibrium and equilibrium phases of erosion was predicted. The surrogate approach was then applied by replacing the variable indicating soil release with a time series of fine soil released during laboratory slaking. Findings show that the temporal stability of the surrogate variables could describe the non-equilibrium and equilibrium detachment for the different soil types and tillage systems. The state space coupled with the surrogate approach proved to be an important and promissory tool to explain the particulate organic carbon release interrill erosion, even in absence of predictive data.

Fault-related folds in the southern Pyrenees

ABSTRACT The fault-related folds observed in the south Pyrenean fold and thrust belt are hybrid structures with elements of detachment folding as well as elements of fault bend and fault propagation folding. Fanning growth strata in all the studied case studies indicate progressive limb rotation during deformation, mainly at their initial stages when fold growing mostly controlled the dispersal of syntectonic sediments as a result of higher uplift rates with respect to sedimentation rates. Break thrusts developed in the fold limb of the initial detachment folds to form fault propagation and fault bend geometries. Inversion folds developed at the rift margins. There the geometry of the folds as well as the brittle deformation patterns are controlled by the inherited fault systems, which are not symmetrical with respect to the fold axis. In the absence of previous structures, brittle patterns developed before or at the initial stages of folding by layer-parallel shortening preserving a symmetrical arrangement with respect to the fold axis.