Initial Age Research Articles

Therapeutic effect analysis of non-invasive ear moldings on correcting congenital auricular deformity in 435 ears

Objective:To evaluate the therapeutic effect of non-invasive ear moldings on correcting congenital auricular deformity of infants. Methods:A total of 435 ears with congenital auricular deformity were treated in the department of Otorhinolaryngology of Chengdu Women and Children's Central Hospital from December 2019 to July 2023. The infants were divided into 3 groups according to the initial treatment age, i. e. , 0-30 days（group A, n=106, 175 ears）, 31-90 days（group B, n=124, 202 ears） and ≥91 days（group C, n=37, 58 ears）. All infants were corrected with Chinese ear moldings. The efficacy, complication rate and treatment duration were compared among the three groups, and the treatments of different types of auricle deformity was analyzed. Results:Through comparison of three groups, the results showed that the markedly effective and cured rate of group A was the highest, and group C was the lowest. The difference was statistically significant（P=0.008）. Specially, there was a significant decrease of after 5 months in Group C. There was no significant difference in the complication rate among the three groups（P=0.232）, and the occurrence of complications has no significant impact on treatment. Group C has the longest treatment duration and group A has the shortest. The difference was statistically significant（P<0.001）. Conclusion:Congenital auricle deformity should be early detected and intervened. The younger the age of children, the better efficacy and shorter treatment duration can be acquired. Children under 5 months still will receive a good treatment. Nevertheless, for children older than 5 months, corrective treatment may also be considered. The efficacy for malformations was significantly lower than that of deformations. The number of cases, efficacy and complication rate for different types of deformations were significantly different.

EP.04C.05 Projected Impact of the Age of Initiation for Lung Cancer Screening on Health Outcomes and Healthcare Resources in Canada

EP.04C.05 Projected Impact of the Age of Initiation for Lung Cancer Screening on Health Outcomes and Healthcare Resources in Canada

Transition From Reverse to Left‐Slip on the Eastern Haiyuan Fault, NE Tibetan Plateau, From the Structure and Age of the Ganyanchi Pull‐Apart Basin

AbstractBecause the active, left‐slip Haiyuan fault is a first‐order structure along the NE margin of the Tibetan Plateau, its tectonic evolution provides insight into deformation processes along this margin over time. Late Cenozoic deformation in the area of the eastern Haiyuan fault initiated as thrust faulting, followed by left‐lateral strike slip displacement. However, the time of this kinematic change has been long debated. Here we use the structural evolution and the age of the Ganyanchi basin to date the onset of this kinematic transition. Seismic reflection data, integrated with published structural mapping, indicate that the basin is a pull‐apart controlled by strands of the eastern Haiyuan fault. Previously reported magnetostratigraphy of a core from the basin interior indicates deposition started at ∼2.8 Ma. However, this age likely postdates initiation of the bounding strike‐slip faults. We estimate that an additional 0.2–1.0 Myr of lateral slip occurred before the dated section formed. Thus, we find that the age of the eastern Haiyuan fault is at least ∼3.5 Ma, which is significantly older than early estimates of less than 2 Ma. Integrating our new data with prior work reveals that the kinematic change from NE‐SW shortening to left‐slip along the Haiyuan fault youngs to the east, which we interpret to result from growth of the Haiyuan strike‐slip fault via progressive lateral propagation from west to east. Miocene‐Pliocene onset of the Haiyuan strike‐slip fault coincides with initiation ages of other major strike‐slip faults in NE Tibet, likely implying that the NE margin of the Tibetan Plateau had switched to a strike‐slip dominated mode of deformation by this time.

Surgical and Camouflage Orthodontic Treatment of Anterior Open Bite: Comparison of Profile Attractiveness.

To evaluate the profile's attractiveness between the different protocols for treating the anterior open bite. The sample comprised 39 patients with anterior open bite treated with or without extractions, divided into two groups: The surgical group (G1) comprised 21 subjects (10 males, 11 females) with a mean initial age of 21.86 years (SD = 5.09), treated with fixed orthodontic appliance followed by orthognathic surgery, for a total mean period of 2.53 years (SD = 0.61). The mean overbite was -5.01 mm (SD = 2.50); The camouflaged group (G2) comprised 18 subjects (9 males, 9 females), with a mean initial age of 20.47 years (SD = 4.19), treated only with fixed orthodontic appliance, for a total mean period of 2.56 years (SD = 0.94). The mean overbite was -4.28 mm (SD = 1.15). Lateral photographs from pretreatment and posttreatment were used. These photographs were evaluated by 46 laypeople and 67 dentists, who rated the attractiveness of each profile from 0 (most unattractive profile) to 10 (most attractive profile). Intergroup comparisons were performed with independent t-tests. Both groups presented improvement in the profile attractiveness with treatment (p < 0.001). Before treatment, the profile of the surgical group was significantly less attractive than the profile of the camouflaged group (p < 0.001). The surgical presented a more attractive profile at the final stage than the camouflaged group (p < 0.001). The surgical group showed a greater improvement in profile attractiveness with treatment than the camouflaged group (p < 0.001). In the final stage, the surgical presented a more attractive and greater improvement in profile attractiveness than the camouflaged group. The laypeople and dentists judged similarly the initial profile attractiveness.

Corrigendum to “A two-stage deformation of the Anatolian Plate deduced fromPaleomagnetic signals: The initial age of the Anatolian’s escape” [Turkish Journal ofEarth Sciences 33 (3) 2024 243-259

Corrigendum to “A two-stage deformation of the Anatolian Plate deduced fromPaleomagnetic signals: The initial age of the Anatolian’s escape” [Turkish Journal ofEarth Sciences 33 (3) 2024 243-259

Women's knowledge of procreative health

Backround: A unique type of health is reproductive health, which represents the entirety of a person’s physical, mental and social well-being, not just the absence of disease or disorder. Reproductive health refers to all issues related to the reproductive system and procreation of women and men in all phases of their lives. Consequently, it includes topics such as puberty and menopause, fertility and infertility, family planning, health during pregnancy, childbirth, and the post-partum period, as well as cancers of the reproductive organs and breasts. This paper presents results of on women’s knowledge of reproductive health in several key areas: sources of information, understanding the concept of ovulation, awareness of factors that positively influence health, knowledge of the most and least fertile ages for women, and preventive measures related to the reproductive system. The aim of the study was to assess the knowledge of adult women aged 18 to 49 regarding reproductive health. Method: The study was based on a questionnaire survey analysed with the IBM SPSS Statistics 27 program. Results: The majority of surveyed women had knowledge about ovulation, with most obtaining their information from the Internet (22.3%). Nearly all female respondents (93.7%) knew what ovulation is. Most women do not use cycle self-observation (75%). The age of sexual initiation for most of the respondents was at 18. More than two sexual partners were reported by nearly 40% of women. Conclusions: The group of women studied was homogenous in terms of the selected qualification criteria, i.e.; all of them were of reproductive age. Fertility knowledge did not correspond with adolescent age of sexual initiation and declared number of partners, which is a risk factor for future reproductive health disorders.

Allostatic Load, Cigarette Smoking, and Lung Cancer Risk.

Background: Allostatic load (AL) is a biomarker of chronic stress associated with various chronic diseases. No study has evaluated the relationship between AL and lung cancer risk. Methods: To address this gap, we analyzed the association between AL and the development of lung cancer in 344,380 participants from the UK Biobank. Results: During the follow-up period from 2006 to 2020, 2517 participants were diagnosed with incident lung cancer. Participants who developed lung cancer had significantly higher AL compared to cancer-free controls (mean: 3.49 vs. 2.87, p < 0.001). In the multivariate analysis, a marginally significant association was observed between higher AL and increased lung cancer risk (per one AL unit: Hazard Ratio [HR] = 1.02, 95% Confidence Interval [CI]: 0.99, 1.04). In the categorical analysis, individuals with high AL (AL > 2) had a 15% higher risk of lung cancer compared to those with low AL (AL ≤ 2) (HR = 1.15, 95% CI: 1.05, 1.25). Stratified analyses revealed that this increased risk was only observed in former (HR = 1.38, 95% CI: 1.06, 1.43) and current smokers (HR = 1.25, 95% CI: 1.10, 1.42) but not in never-smokers (HR = 0.93, 95% CI: 0.74, 1.17). Moreover, we found that demographics, socioeconomics, and other health behaviors could modify the risk association. Finally, among cigarette smoking-related variables, a significant trend of increasing AL was observed with higher pack-years, longer smoking duration, earlier age of smoking initiation, and later age of smoking cessation. Conclusions: These findings suggest that higher AL is associated with an increased risk of lung cancer. The results need to be further confirmed in additional studies.

Toilet Training Readiness Scale for 0-5-Year-Old Children: A New Measurement Tool Based on a Child-Centred Approach.

There is no standardised approach to toilet training in children. This study aimed to determine the factors affecting the duration of toilet training in children aged 0-5 years and to develop a tool to assess the child's readiness to start toilet training. This cross-sectional study was conducted on 409 children aged 0-5 years. Social, economic, behavioural, and developmental characteristics that are effective in toilet training in healthy children were evaluated. A scale assessing children's readiness for toilet training (Toilet Training Readiness Scale-TTRS) was developed and content validated. The mean age of the 409 children included in this study was 44.69 ± 13.07 months (min = 4; max = 60 months). The mean age of initiation of toilet training was 26.8 months. Most frequently, urine and faeces trainings were started together (52.1%). In the logistic regression analysis performed to evaluate the factors affecting the duration of toilet training, it was found that the TTRS score, mother's employment status, family type, child's first reaction, toilet type, and continuity of training were important predictors. The duration of toilet training showed a weak negative correlation with the scores obtained from the TTRS and the number of children in the family but a weak positive correlation with the age at the beginning of toilet training. The TTRS scores were inversely proportional to the duration of toilet training. Family characteristics, socioeconomic conditions, and readiness of the child for and no interruption in toilet training are important in completing toilet training in a short time and successfully. If a child-focused approach is adopted, evaluating the child from this point of view and initiating the training at the appropriate time may help to complete a more successful and shorter toilet training. We recommend that the scale we have developed be studied in other studies and different groups.

Impact of age at ivacaftor initiation on pulmonary outcomes among people with cystic fibrosis

BackgroundIvacaftor (IVA) improves lung function and other extrapulmonary outcomes in people with cystic fibrosis (CF). However, the effect of initiating IVA at earlier versus later ages has not been studied.MethodsWe...

Soybean oil, linoleic acid source, in lamb diets: carcass traits and meat quality.

We developed a study to determine the ideal level of inclusion of soybean oil (SBOil) in the diet without affecting the quantitative and qualitative parameters of the carcass and meat of lambs in a feedlot system; therefore, determining the ideal level of inclusion. Forty male lambs (Santa Inês breed) were used. The initial body weight and age averaged 34.88 ± 3.19kg and 5months, respectively. Experimental units (lambs) were randomly distributed in 5 different diets: inclusion levels of SBOil: 0, 30, 60, 90, and 120g/kg of dry matter (DM). The SOil inclusion reduced the DM intake (P < 0.001), Total digestible nutrients (P = 0.004), and crude protein (P < 0.001). Total weight gain (P < 0.001) decreased with the SBOil inclusion and subcutaneous fat thickness (P = 0.017) showed the same behaviour. The final body weight decreased by 42.9g/kgDM until the inclusion level of 30g/kgDM; from this level it was reduced by 145g/kgDM. The hot and cold carcass weights (P = 0.013) decreased by 36.6g/kgDM after including 30g/kgDM of SBOil. Meat physicochemical composition was not altered (P > 0.05). Lower meat tenderness values ​​were obtained at the levels of 60 and 90g/kgDM. The inclusion above 30g/kgDM decreased meat tenderness. It is concluded that soybean oil should be included up to 30g/kgDM in diets. It is important to note that with diets with 60% concentrate, SBOil levels greater than 30g/kgDM promote yield losses.

A Census of the β Pic Moving Group and Other Nearby Associations with Gaia* * Based on observations made with the Gaia mission, the Two Micron All Sky Survey, the Wide-field Infrared Survey Explorer, the NASA Infrared Telescope Facility, Cerro Tololo Inter-American Observatory, the Southern Astrophysical Research Telescope, Gemini Observatory, the Spitzer Space Telescope, and the eROSITA instrument on the

I have used the third data release of the Gaia mission to improve the reliability and completeness of membership samples in the β Pic moving group (BPMG) and other nearby associations with ages of 20–50 Myr (Sco Body, Carina, Columba, χ 1 For, Tuc-Hor, IC 2602, IC 2391, NGC 2547). I find that Carina, Columba, and χ 1 For are physically related and coeval, and that Carina is the closest fringe of a much larger association. Similarly, Tuc-Hor and IC 2602 form a coeval population that is spatially and kinematically continuous. Both results agree with hypotheses from Gagné et al. I have used the new catalogs to study the associations in terms of their initial mass functions, X-ray emission, ages, and circumstellar disks. For instance, using the model for Li depletion from Jeffries et al., I have derived an age of 24.7−0.6+0.9 Myr for BPMG, which is similar to estimates from previous studies. In addition, I have used infrared photometry from the Wide-field Infrared Survey Explorer to check for excess emission from circumstellar disks among the members of the associations, which has resulted in a dramatic increase in the number of known disks around M stars at ages of 30–50 Myr and a significant improvement in measurements of excess fractions for those spectral types and ages. Most notably, I find that the W3 excess fraction for M0–M6 initially declines with age to a minimum in BPMG (<0.015), increases to a maximum in Carina/Columba/χ 1 For ( 0.041−0.007+0.009 , 34 Myr), and declines again in the oldest two associations (40–50 Myr). The origin of that peak and the nature of the M dwarf disks at >20 Myr are unclear.

Changes and significance of Th1/Th2 and Treg/Th17 cells and their cytokines in patients with alopecia areata

BackgroundAlopecia areata (AA) is a chronic autoimmune disease. Th1/Th2 and Treg/Th17 cells and their cytokines are implicated in AA, and we explored their clinical significance in AA. MethodsAA patients and healthy people (controls) were enrolled, with their Th1/Th2/Th17/Treg cell proportion changes and serum Th1 (INF-γ)/Th2 (IL-5, IL-6)/Th17 (IL-17, IL-22)/Treg (IL-35) cytokine levels assessed. AA patients were assigned into mild, moderate and severe alopecia according to Severity of Alopecia Tool (SALT). The relationship between alopecia severity and initial onset age, disease course, family/smoking/drinking history and sleep disorders was explored. Th1/Th2 and Treg/Th17 cells and their cytokine levels in AA patients with different severity levels were compared. The correlation between cytokine levels and SALT scores was analyzed using Spearman. Additionally, the changes of serum cytokine levels in inactive/active AA patients were compared. ResultsAA patients differed from controls in family history/smoking history/drinking history/sleep disorders. Peripheral blood Th1/Th2/Th17 cell proportions and INF-γ/IL-5/IL-6/IL-17/IL-22 levels increased, while Treg cell proportions and IL-35 level dropped. With higher alopecia severity, the proportions of Th1, Th2 and Th17 cells increased, and Treg cell proportion decreased. AA patients with mild/moderate alopecia had significant differences in IL-17 level. Serum INF-γ, IL-5, IL-17 and IL-22 levels were elevated, and IL-35 level dropped in severe AA patients versus moderate AA patients. ConclusionTh1/Th2/Th17 cell proportions and serum INF-γ/IL-5/IL-6/IL-17/IL-22 levels in AA patients were up-regulated, while Treg cell proportion and IL-35 level were repressed. SALT scores were positively-correlated with serum IL-5/IL-17 levels. SALT scores were negatively-correlated with serum IL-35.

206 Effects of breed type and days on trial on feeding behavior in growing goats fed a total mixed diets using GrowSafe feeding technology

Abstract The objective of this study was to evaluate the effects of breed and days on trial (DOT) on feeding behavior traits in two breeds of growing goats. Nineteen female goats [n = 10 Alpine; n = 9 Spanish, with average initial ages of 360 d and 352 d, and body weight (BW) of 38.8 ± 2.8 kg and 35.5 ± 3.1 kg, respectively], were randomly assigned within the breed to one of two non-adjacent pens (5 goats/pen), each equipped with GrowSafe feed bunks. A pelletized total mixed ration (TMR) was fed twice per day and goats had ad libitum access to feed, water, and mineral block throughout the 84-d trial. Feeding behavior traits, including feed intake, bunk visit frequency (BVF), head-down duration (HDD), and dry matter intake (DMI) were collected daily using the GrowSafe feeding system. A 14-d interval was used to derive feed behavior traits of individual goats at 42, 56, 70, and 84 DOT. Data were analyzed using a repeated-measures model with a fixed effect of breed, DOT as a repeated measure, and breed x DOT interaction with pen as a random effect. Alpine goats had greater (P &amp;lt; 0.05) initial and final BW (37.6 kg and 51.7 kg, respectively) than Spanish goats (34.7 kg and 46.5 kg, respectively) although DMI (P = 0.10; 1.73 ± 0.31 and 1.39 ± 0.18 kg/d) did not differ. There was not a significant difference (P &amp;gt; 0.05) between breeds for frequency of bunk visits (21.1 vs. 18.6) and bunk duration (P &amp;gt; 0.05). Similarly, the effect of breed on DMI (27.1g/min vs. 22.8 g/min) was non-significant (P &amp;gt; 0.05). Furthermore, breed did not significantly (P &amp;gt; 0.05) affect HDD (31.3 min/d vs 31.9 min/d). However, there was a significant interaction (P &amp;lt; 0.05) between breed and DOT for HDD. In addition, significant differences (P &amp;lt; 0.05) were observed due to the length of DOT for BVD, bunk visit duration, HDD, and eating rate (g/min). Our results suggest that Spanish goats tended to visit feed bunks more frequently per day and tended to consume less feed per visit than their counterpart Alpine goats, and the feeding behaviors of goats change with age. However, further research is warranted to determine changes in the feeding behavior of goats in different production cycles.

Association between ossific nucleus volume changes and postoperative avascular necrosis risk in children with developmental dysplasia of the hip

This study aimed to investigate the correlation between ossific nucleus volume and avascular necrosis (AVN) in pediatric patients diagnosed with developmental dysplasia of the hip (DDH). Analyzing 211 cases, including 119 open reduction (OR) and 92 closed reduction (CR) procedures, we quantified ossific nucleus volume using magnetic resonance imaging (MRI). Categorizing the OR group based on ossific nucleus volume revealed no statistically significant difference in AVN incidence. Similarly, in the CR cohort, there was no significant discrepancy in AVN occurrence between subgroups with or without the ossific nucleus. Logistic regression in CR identified the international hip dysplasia institute (IHDI) grade as a significant AVN risk factor (p = 0.007). IHDI grades 3 and 4 exhibited a 6.94 times higher likelihood of AVN compared to grades 1 and 2. Across CR and OR, neither initial age nor ossific nucleus volume emerged as AVN risk factors. In conclusion, ossific nucleus volume does not pose a risk for AVN in DDH children undergoing CR or OR, emphasizing the clinical significance of IHDI grading in predicting AVN risk during CR and the importance of early intervention to prevent treatment delays.

Approved medicines for paediatric solid tumours in Europe: Lessons from the life cycle of a paediatric investigation plan

BackgroundDespite the positive changes brought by the Paediatric Regulation in the European Union (EU) in 2007, drug development in children remains challenging. MethodsTo better understand the issues encountered to reach an authorisation for paediatric patients, we reviewed the pathway of the 11 Paediatric Investigational Plans (PIPs) with indications targeting paediatric solid tumours granted by the Committee for Medicinal Products for Human Use (CHMP) between 2007 and 2022. ResultsOn average 5,5 years were necessary to reach approval after a PIP was agreed. All the PIPs underwent at least one modification (median 3 modifications per PIP). The use of single arm trials, in the context of refractory/relapsed disease in absence of standard of care treatment, was supportive for granting a paediatric indication in the majority of the cases. In 6 out of 11 approved products, extrapolation from adults was used. For 2/11 the approval focused on an older population first compared to the initial age group agreed in the PIP due to the development of a suitable formulation for younger children still ongoing at the time of first approval. Scientific advice sought on paediatric development use of extrapolation from adults, major objections raised by CHMP and post-marketing requirements were examined. ConclusionAnalysing the process necessary to reach an authorisation for paediatric patients, we highlight the major challenges faced in the paediatric approval process and the positive examples of successful drug development that reached final approval. Our analysis is expected to provide useful insights to drug developers, investigators and regulators.

Affective-Sexual Behaviors in Youth: Analysis of a Public Health Survey in the School Setting.

Adolescence is a critical period for the development of affectivity and sexuality. Adolescents begin to explore their sexual identities, form intimate relationships, and learn to manage their emotions in new and complex contexts. This study aims to analyze the prevalence of habits and behaviors related to the affective-sexual health of adolescents in the fourth year of ESO, identifying risk factors, comparing their behaviors and risks, monitoring these behaviors, analyzing their pornography consumption, and evaluating the use of the internet as a source of sexual information. Descriptive cross-sectional study using questionnaires. Participants are fourth-year ESO students from a school in the Baix Llobregat province (Catalonia), aged between 14 and 18 years. Descriptive and bivariate statistical analyses are conducted using the chi-square test and p-value calculations with the R Project software. Frequency and percentage analyses are also used to describe the health behaviors of the participants. The study reveals that girls have better knowledge of the contraceptive pill and male condom than boys. Sexual initiation and condom use management vary between the genders, with girls being more capable of persuading their partners to use them. Pornography consumption also shows significant differences in terms of the age of initiation and frequency between boys and girls. This study on adolescent affectivity and sexuality reveals knowledge about contraceptives, early sexual initiation, and high pornography consumption, highlighting the need for early and diverse affective-sexual education, youth empowerment, and media misinformation management to promote safer and healthier behaviors within municipal public health.

Predictions of Carbon Stock in the Southern Moscow Region Forests Under Different Forest Use Scenarios

The results of forest simulation modelling of the dynamics of carbon pools and fluxes in forest ecosystems under different forest management scenarios were considered on the example of the Dankovsky forest enterprise (south of the Moscow region, subzone of coniferous-broadleaved mixed forests). The impact of such changes in forest management practices, as the reserve regime, the reduction in the proportion of forest lands as a result of residential development, and zoning of the territory with an emphasis on increasing the recreational use of forests on the carbon balance was analysed. In computational experiments, a set of Russian models was used: the dynamic model of a forest stand FORRUS-S, the model of soil organic matter dynamics Romul_Hum, the model of the hydrothermal regime of soils SCLISS. Calculations were performed for a time period of 100 years at the forestry unit level, and were also aggregated at the level of the entire forestry district. The diversity of types of forest growth conditions (FGC), together with the species diversity and the initial different ages of stands, determined significant variations of the calculated indicators of forest stands’ production, the quantity and quality of plant litter entering the soil. For all cases, model estimates of changes in carbon reserves occurred in the forest stands within the initial 40–60 years with a subsequent decrease in the calculated values. Under the conservation scenario, an increase in the organic substances reserves in forest litter and soil was observed: for FGCs C2 and C3, an increase over 100 years was approximately 5–10 kg m–2, for the remaining FGCs — at the level of 2–3 kg m–2 in terms of carbon. Under the economic use scenarios, a relative “levelling” of forest enterprise area towards the lower end of the spectrum was shown in terms of soil carbon reserves. The maximum ecosystem carbon stock was calculated for FGC C2 and C3, the minimum — for A5 and C4. Depending on the scenario, over 100 years, the total net sequestration of carbon by the forests of the Dankovsky forest enterprise (with a total area of forested land of 6836 ha) was estimated within the range of 0.15–0.57 Tg.

Testing Paleomagnetic Dating on Pre‐Historic Flank Eruptions From SE Slope of Etna Volcano

AbstractDuring the last 20 kyr, the Etna volcano has been characterized by almost continuous summit eruptions and by less frequent—yet definitely more destructive—flank eruptions issuing at &lt;1,000 m asl altitudes and reaching the Ionian Sea. The chronological framework of pre‐historic (pre‐2,750 yr BP) flank eruptions is supported only by few radiometric and paleomagnetic ages. Here we paleomagnetically investigated 15 Holocene lava flows from SE Etna lower slopes and dated 12 of them. Paleomagnetic dating at Etna relies on best method pre‐requisites: European location where reference geomagnetic models are well defined, and detailed stratigraphic evidence is available. We sampled 45 sites (450 oriented cores) from lavas loosely constrained in the 19,000–2,000 yr BP age window. Ten eruptions yielded a minimum 40% refinement with respect to initial age constraints, with four lava flows achieving refinement up to 90%. We obtained 620–1,398 yr (998 yr on average) dating accuracy for three flows bracketed in relatively short (1,398–1,644 yr) independent age constraints. By contrast, five flows characterized by longer 6,567–7,439 yr initial age windows yielded multiple age solutions. Finally, four lava flows with 1,644–6,567 yr‐long initial age windows were tightly dated with 120–680 yr age ranges. We conclude that at volcanoes where best paleomagnetic dating pre‐requisite are fulfilled, singular solutions are expected for 30% of the analyzed flows and, significant refinements for the others. Seven kyr seems to represent an independent age window threshold length to get or not significant dating refinements.

P192 PREVALENCE OF HYPERTENSION AND ITS ASSOCIATED FACTORS AMONG PUBLIC VEHICLE DRIVERS IN POKHARA, NEPAL

Introduction: Hypertension, defined as &gt;=140/90 mm Hg or currently taking antihypertensive medicine, is a major public health concern globally, affecting individuals of all ages, backgrounds, and lifestyles. Occupational risk factors associated with hypertension are poorly studied in the context of Nepal, drivers could be at a higher risk of hypertension because of multiple shift work, stress, inactivity, and poor diet. Methodology This cross-sectional study recruited 358 public vehicle drivers from Pokhara Metropolitan City of Nepal. The WHO STEPS questionnaire was used to assess the prevalence of hypertension. Data were entered into REDCap software and analyzed by using SPSS. The chi-square test and binary logistic regression were applied to identify hypertension-related factors. Results: The mean age of the participants was 37.3 ±8.5 years, and all of them were male. The prevalence of hypertension was found to be 41.9%. Using the chi-square test, hypertension was found to be associated with age, lower education, being married, tobacco consumption, age of smoking initiation, alcohol consumption, binge alcohol intake, lower physical activity, obesity, duration of driving, and service. However, when using binary logistic regression, the association was found only with age (OR=0.353; 95% CI: 0.183 to 0.680) and obesity (OR=0.429; 95% CI: 0.234 to 0.783). Conclusion: This study concludes that nearly two-fifths of drivers had hypertension, which is higher than the prevalence in the general population. The research highlights the need to focus on risk factors associated with hypertension among public vehicle drivers in Pokhara, Nepal.

Smoking prevalence among adults in China Mainland and their age of smoking initiation during adolescence: a national cross-sectional study

ObjectivesThis study aims to calculate the national prevalence of smoking among Chinese adults and to describe the hazard of smoking initiation by age during their adolescence, as well as the...