Inhibitors Of Leucine Aminopeptidase Research Articles

The preparation of chloromethylketone analogues of amino acids: Inhibition of leucine aminopeptidase

Chloromethyl ketone analogs of glycine, dl-leucine, dl-alanine, and d-alanine were prepared. The dl-leucine and dl-alanine analogs were potent reversible inhibitors of leucine aminopeptidase. The enzyme was not inhibited by the d-alanine analog.