HomeCirculationVol. 114, No. 22Issue Highlights Free AccessIn BriefPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessIn BriefPDF/EPUBIssue Highlights Originally published28 Nov 2006https://doi.org/10.1161/circ.114.22.2305Circulation. 2006;114:2305MYOCARDIAL INJURY AND VENTRICULAR DYSFUNCTION RELATED TO TRAINING LEVELS AMONG NONELITE PARTICIPANTS IN THE BOSTON MARATHON, by Neilan et al.The popularity of marathon running continues to grow with nearly 400 000 finishing times recorded in 2005. Although the cardiovascular event rate during marathon events is low, recent studies suggest that subclinical myocardial injury may be frequent. In this issue of Circulation, Neilan and colleagues further evaluate this issue by assessing the prevalence of elevated cardiac biomarkers and their association with echocardiographic and Doppler evidence of left and right ventricular dysfunction within minutes of completing a marathon. They also evaluate whether the amount of training prior to the race affects these parameters. The results of this provocative study are highlighted and discussed in an accompanying editorial. See p 2325 (editorial on p 2306).DIAGNOSTIC ACCURACY OF NONINVASIVE CORONARY ANGIOGRAPHY IN PATIENTS AFTER BYPASS SURGERY USING 64-SLICE SPIRAL COMPUTED TOMOGRAPHY WITH 330-MS GANTRY ROTATION, by Ropers et al.Noninvasive evaluation of bypass grafts has been reported using multidetector computed tomographic angiography, but studies of the early-generation scanners have been somewhat limited based on relatively high numbers on unevaluable segments, especially at anastomotic sites or in native vessels. In this issue of Circulation, Ropers et al present a comprehensive report on 64-slice computed tomographic angiography interrogation of patients with previous bypass surgery, examining performance characteristics for detecting significant stenoses in grafts, as well as at anastomotic sites and in distal segments of bypassed native vessels. They report excellent performance for evaluation of occlusions or stenoses in grafts and good performance for grafted and nongrafted native vessels, though limited at times by heavy calcification. The present report provides clinicians with comprehensive data on how to apply computed tomographic angiography in patients with previous bypass surgery and guidance on how to base catheterization decisions on computed tomographic angiography evaluation. See p 2334.A ONCE-DAILY, ORAL, DIRECT FACTOR XA INHIBITOR, RIVAROXABAN (BAY 59-7939), FOR THROMBOPROPHYLAXIS AFTER TOTAL HIP REPLACEMENT, by Eriksson et al.Current oral and intravenous anticoagulants have many limitations including variable patient response, need for monitoring, and drug and food interactions. In the current issue of Circulation, Eriksson and colleagues compare 5 doses of rivaroxaban, an oral, direct inhibitor of coagulation Factor Xa to subcutaneous enoxaparin in patients having elective hip replacement. In the present study of 618 patients, the investigators report that rivaroxaban had similar efficacy as enoxaparin for thromboprophylaxis with increased bleeding at the higher doses. The conclusion is that the 10mg dose of rivaroxaban will provide comparable rates of prevention of thromboembolism at a similar rate of bleeding as enoxaparin. The phase III trial as well as further information on safety and clinical utility of this oral anticoagulant will be eagerly anticipated. See p 2374 (editorial p 2313).Visit http://circ.ahajournals.org:Clinician UpdateClopidogrel Response Variability and Future Therapies: Clopidogrel: Does One Size Fit All? See p e600.Images in Cardiovascular MedicineGiant Atrial Septal Aneurysm in a 25-Year-Old Woman. See p e607.Anomalous Origin and Course of the Right Coronary Artery. See p e609. Download figureDownload PowerPointIntermittent Loss of Second Heart Sound. See p e612.CorrespondenceSee p e614. Previous Back to top Next FiguresReferencesRelatedDetails November 28, 2006Vol 114, Issue 22 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.114.22.2305 Originally publishedNovember 28, 2006 PDF download Advertisement