Inhibition Of Scar Formation Research Articles

Wound repair: the fibroblast and the inhibition of scar formation.

Wound repair: the fibroblast and the inhibition of scar formation.

Regeneration of epidermis by cells grown in tissue culture

Pig epidermal cells were grown in vitro for 21 to 180 days, forming multilayered sheets of epidermis varying from thirteen to forty layers. For an evaluation of their use in wound coverage, they were transplanted onto surgically prepared full-thickness wound beds on domestic swine. Autologous epidermal cells were studied on twenty-five of the animals, and allogeneic epidermal cells were studied on thirteen. Autologous epidermal cells grown in vitro provided functional wound coverage 10 to 15 days post transplantation and inhibited scar formation. Allogeneic epidermal cells “melted” 15 days post transplantation. There was a 7-day prolongation of allograft survival with cultured, as compared with noncultured, epidermal allografts. Results obtained are related to other advances made in this field.

Inhibition of scar formation by the proline analog cishydroxyproline

Inhibition of scar formation by the proline analog cishydroxyproline

Inhibitors of Collagen Biosynthesis as a Means of Controlling Scar Formation in Tendon Injury

After tendon injury, the formation of peritendinous adhesions restricts the gliding of the healed tendon. In this study, attempts have been made to reduce the amount of adhesions with four drugs. Four agents which are known to alter collagen biosynthesis were tested for their ability to inhibit scar formation in the repair of an incision in a tendon. α, α-dipyridyl, beta-aminopropionitrile, D-penicillamine and cis-hydroxyproline were all found to decrease the amount of scan formed around the flexor tendon. α, ά-dipyridyl showed significant toxic side effects. Rats treated with beta-am inopropionitnile showed moderate toxicity. D-penicillamine-treated rats showed minimum toxicity, but with the dose employed, this drug was slightly less effective than the others. Cis-hydroxyproline showed no toxic side effects in our experiments. The inhibition of collagen biosynthesis by proline analogues is a new approach to the problem of reducing scar formation. Further study is needed before considering its use in clinical situations.

Inhibition of scar formation by the proline analog cis-hydroxyproline

Inhibition of scar formation by the proline analog cis-hydroxyproline