Inhibin-like Peptide Research Articles

Synthesis and biological activity of human inhibin-like peptide-(1-31).

A peptide containing 31 amino acids with inhibin-like activity has been synthesized by the solid-phase method. The synthetic product was shown to be homogeneous in high-performance liquid chromatography and paper electrophoresis. In the mouse pituitary incubation system, the follitropin-suppressing activity of the synthetic peptide was comparable to that of the natural product. It was also active in suppressing lutropin-releasing hormone-induced follitropin release in vivo in immature male rats.

Properties of four forms of inhibin-like basic peptides from bull seminal plasma

Properties of four forms of inhibin-like basic peptides from bull seminal plasma

A peptide in gastric secretion with inhibin-like properties.

The presence of inhibin like peptide which is biologically active in reducing FSH secretion in castrated rats and suppressing hCG-induced increase in ovarian weights of immature mice, is reported for the first time in gastric aspirates of normal men. Immunological characteristics of this peptide were similar to inhibin extracted from human seminal plasma. The concentration of inhibin-like peptide measured by RIA developed for seminal inhibin is more than thirty-fold higher in gastric aspirates compared with serum.