Ingestion Of Phenylpropanolamine Research Articles

Risk for Hemorrhagic Stroke with Phenylpropanolamine

Case reports since the 1970s have associated the ingestion of phenylpropanolamine (PPA), a synthetic sympathomimetic drug commonly used in appetite

A Case of Myocardial Injury after Phenylpropanolamine Ingestion

Phenylpropanolamine is a sympathomimetic amine used widely as a decongestant or appetite suppressant. Reports of the myocardial injury from the use of phenylpropanolamine are rare and the mechanism of the myocardial injury is not known clearly. We experienced a case of myocardial injury after ingestion of phenylpropanolamine. A 46-year-old woman was admitted because of chest pain and dyspnea after ingestion of 5 tablets of anorectic pill containing phenylpropanolamine 75 mg per tablet. The serum creatine kinase MB isoenzyme levels were elevated and electrocardiographic abnormalities suggesting myocardial infarction were seen in the precordial lead. In echocardiograpy, left ventricular anteroseptal wall motion was nearly akinetic but coronary angiography showed normal coronary arteries except sluggish blood flow in left anterior descending artery. (Korean Circulation J 2000;30(3):365-368)

Psychiatric disorders associated with phenylpropanolamine ingestion

Psychiatric disorders associated with phenylpropanolamine ingestion

Pseudopheochromocytoma and Cardiac Arrest Associated With Phenylpropanolamine

THE SYMPATHOMIMETIC compound phenylpropanolamine hydrochloride is found in a variety of easily accessible medications including decongestants, anorectics, and stimulants. Serious complications associated with the use of phenylpropanolamine have been described, including hypertension,^1-4headaches,^1-4psychosis,^5,6seizures,^1,2and fatal cerebrovascular accidents.³We recently cared for a 16-year-old girl with a history of recurrent episodes of paroxysmal hypertension and seizures in whom two episodes of cardiac arrest occurred. Her clinical constellation prompted a lengthy and expensive evaluation for pheochromocytoma before surreptitious ingestion of phenylpropanolamine was discovered. Increasing use of phenylpropanolamine-containing medications may make these complications more frequent. <h3>Report of a Case</h3> A 16-year-old girl was hospitalized for evaluation of paroxysmal hypertension. Four months prior to admission she noted the onset of intermittent episodes of headache, diaphoresis, nausea, pallor, abdominal pain, nervousness, and fatigue. These episodes continued until the day of admission, when she was witnessed having a brief

Acute Renal Failure and Rhabdomyolysis After Ingestion of Phenylpropanolamine-Containing Diet Pills

PHENYLPROPANOLAMINE hydrochloride is a sympathomimetic agent found in more than 70 over-the-counter appetite suppressants and nasal decongestants. Acute amphetaminelike CNS stimulation and hypertension, reviewed elsewhere,¹and acute renal failure²have been associated with phenylpropanolamine use. We describe two patients with acute renal failure and rhabdomyolysis following the ingestion of phenylpropanolamine, suggesting that muscle injury may contribute to the renal insult. <h3>Report of Cases</h3><h3>Case 1.—</h3> The patient is the subject of an earlier correspondence.³Acute renal failure developed in a 28-year-old woman after three weeks of ingesting an appetite suppressant containing phenylpropanolamine (Full-stop). She manifested symptoms, signs, and laboratory evidence of rhabdomyolysis and recovered with conservative treatment of her renal failure. She also received ampicillin trihydrate for<i>Escherichia coli</i>bacteriuria. Percutaneous renal biopsy disclosed acute interstitial nephritis, which could have been due to drug ingestion or pyelonephritis. Although it is possible that the renal failure was the

Myocardial injury after phenylpropanolamine ingestion.

Three patients developed clinical evidence of myocardial injury after acute ingestion of phenylpropanolamine, a sympathomimetic amine found in a large number of decongestant and appetite suppressant formulations. Increases in the serum creatine kinase and MB isoenzyme levels, ventricular arrhythmias, and electrocardiographic repolarisation abnormalities were seen. Excessive catecholamine stimulation has been shown to produce acute myocardial necrosis experimentally, and a similar mechanism may be present in these patients.