The long-term effects of cigarette smoking on the respiratory tract have been studied by many authors by making a comparison between the incidence of clinical symptoms and signs of respiratory disease in smokers and that in non-smokers. The extensive literature on this subject was reviewed in the Report of the Royal College of Physicians on Smoking and (1962). Physiological evidence of the short-term effects of cigarette smoking shows that airway resistance, as judged by body plethysmograph records, is increased after the inhalation of cigarette smoke (Nadel and Comroe, 1961; Zamel, Youssef, and Prime, 1963). Physiological evidence of longer-term ventilatory defect attributable to cigarette smoking has been obtained by a comparison of ventilatory capacity in groups of smokers and non-smokers. Thus, Higgins (1959) found that indirect maximum breath ing capacity, based on measurements of three quarter second forced expiratory volume, was significantly lower in smokers than in non-smokers in random samples of men in England and Wales. Carey, Merrett, Elwood, Pemberton, and McAulay (1965) derived regression equations for the pre diction of one-second forced expiratory volume, FEV(l), and forced vital capacity, FVC, on age and stem height in non-byssinotic non-preparers in the flax-spinning industry; their findings were compatible with the hypothesis that, for a given age, sex, and stem height, and under similar conditions of exposure to occupational dust and similar resi dential exposure to air pollution, average values of FEV(l) are lower in smokers than in non-smokers. In what follows, an attempt has been made to compare daily changes in ventilatory capacity in a group of smokers with those in a group of non smokers, matched as closely as possible for relevant physical attributes as well as for occupation. Methods The subjects for the survey were selected from the sta f of Public Health Inspectors employed by the Belfast County Borough Health Committee. Out of a possible total of 52 men, 47 were seen at a preliminary interview when the age, stem height, and smoking habits of each man were recorded. As ventilatory capacity is known to be affected by age and by stem height (e.g. Carey and others, 1965), each smoker* was matched as closely as possible with a non-smoker with respect to age (?2 years) and stem heightt (?2 cm.). Seven smokers and seven non-smokers met these criteria for matching (Table I). The amounts smoked by the smokers had not varied greatly for at least the previous year, and no control had ever smoked in his life. A Poulton spirometer (McKerrow, McDermott, and Gilson, 1960) was used for the measurement in litres of forced expiratory volume?1 second, FEV(l), and forced vital capacity, FVC. The timing mechanism of the instrumert was calibrated, and the water temperature of the spirometer was taken before each series of tests. On each of the five days of the experiment, the water temperature of the spirometer was found to be within the range 15?-25? C, at which the accuracy of the instrument is better than ? 2 per cent., so that no further corrections were made to FEV(l) or FVC measure ments for temperature or barometric pressure changes. Each public health inspector participating in the study was instructed in the correct method of doing spirometry tests before the first day of the