Objective: To compare the anesthetic efficacy of 4% articaine associated with epinephrine concentrations of 1:100,000 and 1:200,000, using the infraorbital nerve block approach. Material and Methods: This is a double-blind cross-sectional study conducted with 40 volunteers. Pulpal anesthetic parameters such as latency, duration, and success rates were evaluated using a pulp tester device, which emits electrical discharges ranging from 0 to 80 ?A in 20 seconds. Soft tissue anesthesia (vestibular gum) was evaluated by pressing a wooden toothpick into the gingival region used in the approach. Finally, parameters related to pain after anesthesia were evaluated. Results: We found no statistically significant differences between anesthetic solutions for pulp and soft tissue regarding latency period. The anesthetic solution containing 1:100,000 epinephrine presented a significantly longer effect duration than 1:200,000 epinephrine regarding pulpal anesthesia of maxillary central incisors, first maxillary premolar, and second maxillary premolar. As for vestibular gum, we found no statistically significant differences between the solutions. Regarding pain at injection, the two anesthetic solutions showed no statistically significant differences. Conclusion: 4% articaine with 1:100,000 epinephrine presented significantly longer pulpal anesthesia duration in some dental elements when compared to 1:200,000 epinephrine
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