Landslides are unpredictable; however, the susceptibility of landslide occurrence can be assessed using qualitative and quantitative methods based on the technology of the Geographic Information Systems (GIS). A map of landslide inventory was obtained from the previous work in the Minamata area, the interpretation from aerial photographs taken in 1999 and 2002. A total of 160 landslides was identified in four periods. Following the construction of geospatial databases, including lithology, topography, soil deposits, land use, etc., the study documents the relationship between landslide hazard and the factors that affect the occurrence of landslides. Different methods, namely the logistic regression analysis and the information value model, were then adopted to produce susceptibility maps of landslide occurrence. After the application of each method, two resultant maps categorize the four classes of susceptibility as high, medium, low and very low. Both of them generated acceptable results as both classify the majority of the cells with landslide occurrence in high or medium susceptibility classes, which could be believed to be a success. By combining the hazard maps generated from both methods, the susceptibility was classified as high–medium and low–very low levels, in which the classification of high susceptibility level covers 6.5% of the area, while the areas predicted to be unstable, which are 50.5% of the total area, are classified as the low susceptibility level. However, comparing the results from both the approaches, 43% of the areas were misclassified, either from high–medium to low–very low or low–very low to high–medium classes. Due to the misclassification, 8% and 3.28% of all the areas, which should be stable or free of landsliding, were evaluated as high–medium susceptibility using the logistic regression analysis and the information value model, respectively. Moreover, in the case of the class rank change from high–medium susceptibility to low–very low, 35% and 39.72% of all mapping areas were predicted as stable using both the approaches, respectively, but in these areas landslides were likely to occur or were actually recognized.