Information Tools Research Articles

Associations of cumulative voriconazole dose, treatment duration, and alkaline phosphatase with voriconazole-induced periostitis.

To investigate the associations of cumulative voriconazole dose, treatment duration, and alkaline phosphatase with voriconazole-induced periostitis. One hundred and thirty-one patients with voriconazole use were identified using a clinical informatics tool. Health record data including age, sex, immune status, alkaline phosphatase, voriconazole levels, voriconazole dose, frequency, and treatment duration were collected. Imaging studies during the duration of treatment were reviewed by two radiology trainees and imaging features of voriconazole-induced periostitis were confirmed by a board-certified musculoskeletal radiologist. The length, location in the body, location in the bone, type, and morphology of periostitis lesions were recorded. Incident voriconazole-induced periostitis was defined as new periostitis on imaging after 28days or more of voriconazole treatment in the absence of an alternative diagnosis. Univariate Firth's logistic regression models were performed using cumulative voriconazole dose, treatment duration, and average ALP as predictors and incident VIP as the outcome. There were nine patients with voriconazole-induced periostitis and 122 patients without voriconazole-induced periostitis. The most common lesion location in the body was the ribs (37%) and morphology was solid (44%). A 31.5-g increase in cumulative voriconazole dose was associated with 8% higher odds of incident periostitis. Increased treatment duration (63days) and higher average alkaline phosphatase (50IU/L) were associated with 7% higher odds of periostitis and 34% higher odds of periostitis, respectively. Increased cumulative voriconazole dose, treatment duration, and average alkaline phosphatase were associated with higher odds of voriconazole-induced periostitis.

Evaluating the genetic variability in selected accessions of medicinal legume Mucuna pruriens (L) DC through ISSR markers

Mucuna pruriens, a widely available but underutilized legume in India, stands out for its nutritional and medicinal potential. Understanding the genetic diversity of M. pruriens is vital for its conservation and utilization in breeding programs aimed at enhancing its nutritional and agronomic traits. In this regard, molecular markers like ISSRs offer a reliable and informative tool for assessing genetic diversity. In the present study, 23 M. pruriens accessions from northeastern India were evaluated using ISSR markers, revealing high levels of polymorphism and significant genetic diversity. A total of 512 amplicons were generated across 33 ISSR primers, with an average polymorphic percentage of 98.05 %. PIC values ranged from 0.22 to 0.50, indicating substantial genetic variation within the accessions. Supplementary indicators such as EMR and MI were employed to evaluate the marker system's efficacy. EMR ranged from 6 to 22, averaging 14.95, while MI ranged from 2.64 to 9.02, averaging 6.04, with a positive correlation observed between EMR and MI. Cluster analysis based on Jaccard's similarity coefficient classified the accessions into two major groups, with the northeastern Indian accessions displaying higher diversity compared to those from other regions of India. Interestingly, geographical proximity did not consistently correlate with genetic similarity, suggesting complex patterns of gene flow and historical germplasm exchange. Overall, this study provides valuable insights into the genetic diversity of M. pruriens and highlights the importance of conserving and utilizing this underutilized legume for addressing global food security challenges.

Patient and family engagement in patient safety practices: A Making Healthcare Safer rapid response review

Background Patient and family engagement (PFE) is a developing area in reducing patient harm. This review addresses two questions: 1) What PFE patient safety practices (PSPs) have been used to prevent, report, or mitigate harms to patients and in what settings have they been used? 2) What evidence of effectiveness and unintended effects of PFE PSPs has been published since the Making Healthcare Safer (MHS) III report? Methods We searched PubMed and the Cochrane Library for studies published between January 2019 and April 2023. We included reviews of and primary studies on safety, quality, or utilization outcomes associated with any intervention focused on PFE in reporting and/or reducing patient safety events and harms. Results We retrieved 768 citations and found one systematic review and five studies meeting the inclusion criteria. The studies were either multi-component patient fall interventions or patient portals and information tools. Patient fall intervention PFE PSPs demonstrated significant decreases in overall rate of fall (15%–71% reductions) and fall with injury (34%–67% reductions) across three studies and a 17% decrease in the hospital length of stay in one study. Across three studies employing portals and information tools, PFE PSPs facilitated the identification of errors and significantly decreased the hospital length of stay and readmissions. Conclusions Research on PFE PSPs provides emerging evidence of the effectiveness of including PFE as a component of interventions targeting specific preventable harms. More research is needed to support the measurement of and better determine the overall effectiveness of a broader implementation of PFE PSPs.

Strategies for Developing Pre-Employment Adaptability from a High-Quality Employment Perspective: An Analysis of College Students' Job Preparation Behaviors

This study surveyed the job preparation behaviors of 210 college students and proposed strategies for job preparation behaviors that college students need to adapt to before entering the workplace. The results indicate that the overall level of students' job preparation behaviors is moderately average (M=3.07). Among the sub-factors of goal achievement behaviors, tool preparation behaviors, and information gathering behaviors, goal achievement behaviors scored the highest (M=3.14). Male students had higher scores in information gathering and tool preparation behaviors than female students; senior students outperformed junior students in information gathering; and students in science and engineering majors scored higher in information gathering and tool preparation behaviors than those in humanities and social sciences. The findings of this study have practical significance for optimizing and improving employment planning education in higher education and provide a foundational reference for research in high-quality employment, employment equality, and industry-education integration.

Performance evaluation of bus stops on arterial roads in Hanoi city

The operations of critical bus stops on arterial roads substantially influence the facility bus capacity and the bus quality of service in terms of schedule reliability. The aim of this article is to employ the methodology in the Transit Capacity Quality of Service Manual (TCQSM) to better understand the performance of key bus stops on arterial roads in Hanoi city. The obtained results shown that the capacities of most examined bus stops (Bus Stops 02, 03, and 04) are considerably lower than the actual demands of buses on the considered roads, and increasing the number of loading areas at bus stops is one of the feasible solutions to effectively improve the capacity of bus stops in Hanoi city. The results achieved provide urban transport management agencies and public transport practitioners in Vietnam with a valuable tool for bus stop capacity measurement and additional information for bus quality of service improvement

Parameterization of Maxwell - Cremona Diagram for Determining Forces in Elements of a Scissors Truss

An analysis of changing patterns of the values of member forces in a scissors truss, depending on the position of connections of its lower chords to the upper chords, is performed. Exploring effective truss structure designs in terms of balanced combination of maximum strength and minimum weight is a sustainable approach to a more rational use of building materials and the development of green construction. This determines the relevance of this area of research. The analysis of configurations of the truss under study was performed using the parameterized Maxwell - Cremona diagram. Such diagram is a visually informative tool in presenting the calculation results and it fully reflects the relationship between the member forces and the parameters of the structure. The research process was performed using the MS Excel spreadsheet editor. This eventually developed into a software tool for finding effective scissors truss designs, which has full potential for further improvement and development. Thus, the functionality of the tool can be easily expanded to designing scissors trusses made of various structural materials, as well as with various crosssectional shapes of its elements. The proposed approach to the calculation of such structures can serve as a basis for parameterization of trusses with other types of web.

Identification of the 18 World War II executed citizens of Adele, Rethymnon, Crete using an ancient DNA approach and low coverage genomes

In the Battle of Crete during the World War II occupation of Greece, the German forces faced substantial civilian resistance. To retribute the numerous German losses, a series of mass executions took place in numerous places in Crete; a common practice reported from Greece and elsewhere. In Adele, a village in the regional unit of Rethymnon, 18 male civilians were executed and buried in a burial pit at the Sarakina site. In this study, the first one conducted for a conflict that occurred in Greece, we identified for humanitarian purposes the 18 skulls of the Sarakina victims, following a request from the local community of Adele. The molecular identification of historical human remains via ancient DNA approaches and low coverage whole genome sequencing has only recently been introduced. Here, we performed genome skimming on the living relatives of the victims, as well as high throughput historical DNA analysis on the skulls to infer the kinship degrees among the victims via genetic relatedness analyses. We also conducted targeted anthropological analysis to successfully complete the identification of all Sarakina victims. We demonstrate that our methodological approach constitutes a potentially highly informative forensic tool to identify war victims. It can hence be applied to analogous studies on degraded DNA, thus, paving the path for systematic war victim identification in Greece and beyond.

Simulation of decision-making processes regarding the formation of an invest-ment portfolio using IT

Significant changes observed in the global economy and in particular in Ukraine in recent years have significantly increased interest in the problems of investment theory. An example of this is the intensification of trading in shares of large and medium-sized international companies and cryptocurrencies, which causes a rapid increase in their values. It is known that in the theory of investments, the task of optimizing the set of components of investment portfolios is considered as a special case. As you know, the issue of decision-making regarding the formation and optimization of an investment portfolio is in the field of attention both for large investment companies and for private investors, since when choosing among possible alternatives for the distribution of capital investments within the market of financial assets, the investor will receive different results. As a result, it is necessary to understand the amount of income received during the period of ownership of the investment portfolio. It is known, according to Gary Markowitz's theory of investment risk, that the optimal distribution of the filling of the investment portfolio should provide the best income while maintaining the lowest risks. At the same time, the decision regarding the structure of capital distribution is often made in conditions of uncertainty, and the profitability of investing capital in investment objects is of a random nature. Since uncertainty creates additional risks, the investment of capital and the task of optimizing the investment portfolio must be considered and solved in the presence of risk. At the same time, effective investment activities require the use of special mathematical methods and informational tools to support decision-making. In the article, using the Ruby programming language, a model is proposed that can be used in the decision-making process when forming a set of components of a portfolio of securities, which allows potential investors to independently assess the effectiveness of a set of investment portfolios by comparing the growth dynamics of shares available on the financial market. It is known that most of the information an investor encounters is in a tabular format, and according to the methodology of scientific knowledge, a person better perceives visualized ways of presenting information. The model proposed in the work uses visualization tools built into the software product, which presents available tabulated information in a structured graphic form.

ANALYSIS OF PARTICULAR SYSTEMS AND APPLICATIONS IN THE MODEL OF BLENDED LEARNING IN SECONDARY EDUCATION INSTITUTIONS

ANALYSIS OF PARTICULAR SYSTEMS AND APPLICATIONS IN THE MODEL OF BLENDED LEARNING IN SECONDARY EDUCATION INSTITUTIONS

Logistic Model Usage Factors Apps to University Students

In the age digitalized information and technology its show a phenomenon that the applications new technologies with young generate dependence to dispositive, in special the mobile application and smartphones it is are grate tools to process management academic in the higher education institutions. Is intends develop the logit econometric model to determine the probability of using the necessary information tools in an academic App for university students. The study determines five (4) information factors required by students to consider them of quality. The results show that the factors identified are associated with information from academic administrative processes, academic information, interactive connectivity and other general ones. It concludes that observed factors that the

Rancang Bangun Game Adventure 3D Edukasi Sampah Organik dan Non-Organik

This research aims to design and develop an Educational 3D Adventure Game as an informative tool for organic and non-organic waste. The development method employed is MDLC (Multimedia Development Life Cycle), encompassing Concept, Design, Material Collecting, Assembly, Testing, and Distribution stages. The game was successfully created for the Android platform using Unity3D.The testing results, involving 22 respondents from Gedang Rowo Village, demonstrate a positive response with an approval rate of 90%. Media experts' evaluation reached 68%, while content experts provided a 100% approval rate. These findings indicate that "TrashHero" has effectively become an engaging and interactive information medium regarding organic and non-organic waste.Utilizing the Likert scale, the conclusion drawn from the testing affirms that "TrashHero" has achieved a remarkably high level of success. Therefore, this game is considered an effective educational tool for conveying information about waste while providing an interactive experience for users.

Development of information and didactic tools for practice-oriented education in universities

Relevance. The relevance of the research is determined by the change in the educational environment, which contributes to the search for new innovative methods of training qualified specialists capable of solving any tasks within their professional activities. Purpose. The purpose of the paper is to analyze the characteristics of practice-oriented education in Kazakh higher educational institutions in accordance with the development of information and didactic tools. Methodology. General scientific theoretical methods were used in the work, such as comparison, synthesis, system analysis, systematization, generalization and statistics, the method from abstract to concrete based on systemic and structural-functional approaches. Results. The author analyzed a number of scientific and methodological Kazakh and foreign sources to determine the semantic component of the phenomena of "practice-oriented education" and "information didactic tools". The current state was considered of the practice-oriented conception of learning in Ukrainian, Russian and Australian universities. The interpretation was substantiated of information and didactic means as material tools of professional interaction of subjects of the educational process. Practice-oriented education was analyzed in universities of the Republic of Kazakhstan, and key information and didactic tools were identified, including very open online courses, case-methods "Workbook", individualized electronic education programs. The promising vector was confirmed of the development of practice-oriented education in Kazakh universities based on statistical data of the state of previous years. Conclusions. It became evident that contemporary educational paradigms prioritize an activity-based approach, necessitating the refinement of pedagogical foundations. Various studies, both local and international, were scrutinized to grasp the nuances of developing informational teaching tools and integrating practical learning methodologies. It was established that a comprehensive analysis of these concepts is imperative. "Practice-oriented education" emerged as a holistic system of innovative teaching techniques designed to enhance essential aspects of a student's development, encompassing psychological, cognitive, motivational dimensions. Keywords: innovative education; didactics; activity approach; applicants for higher education; educational practice; information and didactic competence

MigraineTracker: Examining Patient Experiences with Goal-Directed Self-Tracking for a Chronic Health Condition.

Self-tracking and personal informatics offer important potential in chronic condition management, but such potential is often undermined by difficulty in aligning self-tracking tools to an individual's goals. Informed by prior proposals of goal-directed tracking, we designed and developed MigraineTracker, a prototype app that emphasizes explicit expression of goals for migraine-related self-tracking. We then examined migraine patient experiences in a deployment study for an average of 12+ months, including a total of 50 interview sessions with 10 patients working with 3 different clinicians. Patients were able to express multiple types of goals, evolve their goals over time, align tracking to their goals, personalize their tracking, reflect in the context of their goals, and gain insights that enabled understanding, communication, and action. We discuss how these results highlight the importance of accounting for distinct and concurrent goals in personal informatics together with implications for the design of future goal-directed personal informatics tools.

Perception of journalism students regarding TikTok as an informative tool

TikTok es una red social que ha experimentado un crecimiento exponencial desde 2020. Su modo de funcionamiento, con vídeos cortos y basándose en la caja de skinner, hace que se trate de una de las redes sociales más adictivas. Su usuarios, principalmente adolescentes y adultos jóvenes, pasan largos períodos de tiempo consumiendo los contenidos que se ofrecen, convirtiéndose así en una potente herramienta de comunicación. El presente artículo analiza la percepción de los estudiantes de periodismo de la red social TikTok como herramienta de difusión de contenidos informativos. Para ello, tras la ejecución de una práctica en esta red social en clase, se realizó una encuesta a los estudiantes. En esta se muestra cómo estos, pese a ser muy reticentes en un inicio a usar TikTok como herramienta informativa, cambiaron su valoración acerca de ella percibiéndola como una útil plataforma donde desarrollar su labor periodística.

E-Pest Surveillance for Assessment of Seasonal Occurrence of Orange Pests in Maharashtra

Monitoring of incidence and intensity of pests over the crop season is crucial for effective pest management. ICT (Information and communication technology) not only enables the assimilation of pest databases over space and time, but also aids in the rapid processing of data to make pest management decisions using the available knowledge base and essential inputs that can be mobilised and adopted for plant protection on wide area basis. This study generated valuable data on the population dynamics of orange pests over the seasonal months from 2012 to 2022 with the aid of applied information and communication technology tools. The majority of the pests under current study showed their seasonal activity throughout the monitoring period. The study on the seasonal incidence revealed bark eating caterpillar Inderbela sp. having their peak infestation during September and October whereas January to March were observed as prime months for fruit sucking moths Othreis sps to reach their peak prevalence and damage. The citrus leaf miner Phyllocnistis citrella population dynamics showed two peaks in August and September. The data generated in this study would help in the forecast of the pests and helpful in devising an effective IPM strategy.

Experimental Validation of Electrothermal and Aging Parameter Identification for Lithium-Ion Batteries

Modeling and predicting the long-term performance of Li-ion batteries is crucial for the effective design and efficient operation of integrated energy systems. In this paper, we introduce a comprehensive semi-empirical model for Li-ion cells, capturing electrothermal and aging features. This model replicates the evolution of cell voltage, capacity, and internal resistance, in relation to the cell actual operating conditions, and estimates the ongoing degradation in capacity and internal resistance due to the battery use. Thus, the model articulates into two sub-models, an electrothermal one, describing the battery voltage, and an aging one, computing the ongoing degradation. We first propose an approach to identify the parameters of both sub-models. Then, we validate the identification procedure and the accuracy of the electrothermal and aging models through an experimental campaign, also comprising two real cycle load tests at different temperatures, in which real measurements collected from real Li-ion cells are used. The overall model demonstrates good performances in simulating battery characteristics and forecasting degradation. The results show a Mean Absolute Percentage Error (MAPE) lower than 1% for battery voltage and capacity, and a maximum absolute error on internal resistance that is on par with the most up-to-date empirical models. The proposed approach is therefore well-suited for implementation in system modeling, and can be employed as an informative tool for enhancing battery design and operational strategies.

Institutional Factors as Precursors of Consortium Building Readiness among University Libraries in Southwestern Nigeria

In many countries, especially developing ones like Nigeria, university libraries face tremendous challenges in meeting the needs of the ever-growing world of knowledge and information, particularly the demands of their users. These challenges result from diminishing budgets and the galloping cost of subscriptions to periodicals, purchasing materials, and Information and Communication Technology (ICT) tools, and they have warranted the need for building consortia among university libraries as an approach to address the foregoing problems. University libraries must, therefore, be ready for consortium building by providing institutional factors within them. The study investigated institutional factors as precursors of consortium building readiness among university libraries in Southwestern Nigeria. It adopted the survey design of the correlational type. Total enumeration was used to sample all 643 library personnel in the 45 university libraries in Southwestern Nigeria. The library staff sampled possess at least a diploma or degree in Library and Information Science, even a PhD. There are 45 universities located in Southwestern Nigeria. 549 copies of the questionnaire were returned and used for the study, giving a response rate of 85.4 per cent. The self-constructed questionnaire and interview schedule validated and tested on 30 library personnel at the University of Ilorin, Kwara State, Nigeria, were used for data collection. The data was analysed qualitatively and quantitatively using descriptive and inferential statistics, correlation, and regression analysis. Findings revealed that organisational culture (=3.20; std dev. =0.66) was the most prevalent institutional factor for consortium building. It was followed by ICT literacy skills (=3.18; std dev. =0.64), electricity (=3.16; std dev. =0.73), automation/digitisation (=3.09; std dev. =3.95), training (=2.91; std dev. =0.83), Internet connection (=2.90; std dev. =0.78), finance (=2.89; std dev. =0.81), and organisational policy (formal written document) (=2.79; std dev. =0.81). The findings also reveal that institutional factors altogether (r = .508; p<0.05) have a significant positive relationship with consortium building readiness among university libraries in Southwestern Nigeria. Institutional factors aid consortium building readiness among university libraries in Southwestern Nigeria. The study recommends that university libraries must provide institutional factors to show their readiness for consortium building.

Abstract PO2-10-12: The devil is in the details: Workflow analysis of breast cancer treatment decision making and implications for decision support design

Abstract While numerous decision aids have been developed to support treatment decision-making in breast cancer1, widespread implementation remains limited due to challenges integrating these tools in clinical workflows2. Given these persistent issues, we need to better understand the complex workflows and needs of decision aid users - patients, their family caregivers, and breast cancer clinicians. Previous studies have explored various aspects of breast cancer team workflows3,4. Despite this work, it is still unclear how these complex workflows support or hinder decision aid use. In this study, we conducted an in-depth analysis of breast cancer team workflow to elicit design requirements for informatics tools to support patient-centered decision-making. This study was part of a larger project aimed at designing a COMputeried PAtient-centered Collaborative Technology (COMPACT) to support personalized decision-making for breast cancer patients. We conducted observations of clinicians and patients at one breast center, using a tablet computer with smart pen to take notes on all aspects of clinic workflow. We uploaded all observation notes into a qualitative data analysis software, Dedoose. Two researchers coded the observations in an inductive, consensus-based process. We met to review our codes and identify key themes emerging in the data. We observed 95 hours and 127 patient encounters across 20 clinician-centered and 8 patient-centered observations. We identified 10 themes related to the design of decision support, which we grouped into the 4 components of workflow6 (see Table 1). We identified numerous patient-specific factors communicated from the patient to the clinical team that influenced treatment decision-making. These “decision factors” covered the broader scope of the patient’s life that was important in the decision-making process (e.g., upcoming family wedding, work). Patients were frequently “knowledge brokers” and were asked to remember and relay information across members of the care team. We identified 28 different tools and technologies used to support treatment decision-making. Patient family caregivers (e.g., aunt, husband) played an important role in treatment decision-making. Based on these findings, we developed design requirements for informatics tools to better support patients (and clinicians). Our study highlights the complexity and interdependence of breast cancer treatment decision-making. Patients frequently made treatment decisions that influenced subsequent decisions. Decision aids typically focus on one decision or one care specialty and do not support consideration of several treatment options at one time1. Future research is needed to determine if and how decision support tools could incorporate the broader scope and interdependence between decisions to support patient-centered care. We highlight the need for informatics tools to consider the diverse and unique decision factors (e.g., hobbies) that are crucial to patient-centered decision-making. Decision support could help to elicit and incorporate these factors during treatment decision-making. However, the variable nature of these patient-specific factors presents a challenge to decision support design. Further research is needed to determine how to optimally incorporate such factors into decision support tools. We found inadequate system support for clinicians’ tasks including limited feedback loops to notify clinicians of completed tasks (e.g., mammogram, genetic testing). As a result, patients were often responsible for relaying information to and between different members of the clinical team. Given that patients only remember 50% of what clinicians tell them during visits7, a better system is needed to improve the reliability of information transfer. Our design guidelines can be used to improve the design of decision support tools and ultimately improve patient-centered decision-making. Table 1. Workflow components, themes, and associated challenges to decision support design Citation Format: Megan Salwei, Carrie Reale. The devil is in the details: Workflow analysis of breast cancer treatment decision making and implications for decision support design [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-10-12.

Abstract PO3-15-04: Oncotype DX Recurrence Score as an Informative Tool to Optimize Neoadjuvant Therapy in HR-positive, HER2-negative Breast Cancers

Abstract Oncotype DX Recurrence Score as an Informative Tool to Optimize Neoadjuvant Therapy in HR-positive, HER2-negative Breast Cancers Background: Neoadjuvant therapy (NAT) in HR+/HER2- breast cancers rarely leads to pathological complete response (pCR) and often doesn’t achieve substantial tumor shrinkage. Therefore, neoadjuvant therapy in HR+/HER2- breast cancers has the most value in the assessment of in vivo treatment response. For this purpose, biomarkers that can predict clinical and pathological response to systemic therapy could help inform treatment. The role of Oncotype DX testing in the management of early-stage HR+/HER2- breast cancer has been widely recognized in the adjuvant setting. However, no large prospective studies evaluating the Oncotype DX test in the neoadjuvant setting have clearly shown its predictive or prognostic utility to date. In this study, we evaluated the effect of the recurrence score (RS) on systemic treatment recommendations and its correlation to NAT response. Methods: Patients with clinically selected T2-T4 and/or clinically node positive HR+/HER2- breast cancer who were referred to BC Cancer Vancouver for consideration of NAT between September 2021 – April 2023 were screened for study eligibility. Suitable candidates who agreed to participate in the study had Oncotype DX testing on core biopsy specimens and Ki-67 testing on the core biopsy and final resection specimen. Clinico-pathological information, treatment regimens, operative details, and clinical, radiologic, and pathological responses were recorded. Results: Of the 66 patients who met eligibility criteria, 40 enrolled in the study comprising the accrual rate of 60.6 %. There were multiple factors that influenced patients and/or Oncologists participation in the study highlighting the low uptake of NAT in HR+/HER2- tumors. Technical feasibility of obtaining Oncotype DX from core biopsy samples was 95% which correlates with our previously reported data on a smaller cohort. The mean turnaround time from patient consent to RS report was 18.5 calendar days. The mean time from the initial consult to the start of NAT was 18.8 calendar days. Amongst all tumors tested, 28 % had RS equal or greater than 26 while only 2 % of participants had a score less than 10. Overall, 32 % of treatment recommendations were changed based on RS. Approximately 31% of patients who were initially recommended to receive neoadjuvant chemotherapy were spared from this treatment based on low RS. Conversely, 23.8% of patients who were recommended to pursue upfront surgery were escalated to chemotherapy due to a high RS. Approximately 88 % of the participants who were treated with neoadjuvant chemotherapy had a favourable clinical response and 38.5% had a complete clinical response. There were no pCR observed amongst patients who completed surgery after neoadjuvant chemotherapy, but half of them were rendered eligible for less surgery (either spared a mastectomy and/or an axillary dissection). Conclusions: Oncotype DX testing changed systemic treatment recommendations in one third of neoadjuvant patients and presents a unique opportunity for personalized medicine. Pre-operative testing thus influenced clinical decision-making, allowing treatment de-escalation and omission of chemotherapy in those with a low RS and conversely an earlier escalation of systemic therapy for those with a high RS. Turnaround time of the Oncotype DX assay on a core biopsy sample was acceptable and did not significantly delay treatment initiation. The benefit of the Oncotype DX assay prior to NAT was valuable for predicting in vivo response although pCR was not observed in any of the patients enrolled. Analyses are ongoing to further correlate RS to neoadjuvant response and to dynamic Ki-67 and MRI changes. Citation Format: Lidiya Luzhna, Stephen Chia, Mehrnoosh Pauls, Nathalie Levasseur. Oncotype DX Recurrence Score as an Informative Tool to Optimize Neoadjuvant Therapy in HR-positive, HER2-negative Breast Cancers [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-15-04.

Awareness and utilization of mother and child protection (MCP) card among mothers attending immunization OPD: An urban health centre-based cross-sectional study.

The MCP card is used as a tool for pregnant women, young mothers and family members to learn about various types of services which they should assess and utilize. The study was undertaken to see the awareness about MCP card and its components among beneficiaries in urban slum area. This is a cross-sectional observational study done in urban slum immunization OPD with a sample size of 226. Convenient sampling method was used to select the samples. Mothers consenting and willing to participate in the study were enrolled. Observed that the MCP card was issued to majority participants at the time of baby immunization (44.15%), followed by at time of delivery (31.4%) and least number received it at the time of pregnancy registration (24.34%). It is also observed that only 53.54%(121) women had read the card while the remaining didn't. Majority thought the primary use of MCP card was vaccination record (91.5%), followed by information tool (52.%). It is observed that knowledge regarding pregnancy care and its related complications leads to better utilization of ANC services. As observed in the present study a sizeable proportion of populations doesn't even read the card, and among those who read it the level of knowledge isn't satisfactory, many use the card as a vaccination record but still the awareness about various vaccines among the beneficiaries remains low.