The effective harvesting of groundwater and its sustainable management is possible with the proper identification of zones on its potential basis. For this purpose, geographical information system (GIS) and Remote Sensing (RS) data approaches were combined and used for the investigation, preservation, and evaluation of groundwater supply. This study aimed to assess groundwater delineation and availability-based potential of groundwater area in Charsadda District, KPK, Pakistan, by applying the approach of RS, GIS, and multi-influencing factors (MIF). For this purpose, digital elevation model (DEM), shuttle radar topographic mission (SRTM), and sentinel 2 satellite images were employed to produce numerous thematic layers, i.e., land use land cover (LULC), drainage density, lineament density, geology, slope soil, and rainfall as MIF in this study. After assigning a fixed score and weight to each thematic layer (MIF techniques), then an analyzed spatial layer was combined with a weighted overlay using ArcGIS software (ArcMap 10.5) and finally potential area for groundwater was defined. The obtained potential area of groundwater was categorized spatially as, very high, high, moderate, and low zones which depict most of the area is covered with moderate (547.66 km2) to high (306.7 Km2), as well as, high highest groundwater potential in 7 km2. The results of this study and the approach will be applicable and insightful for regional and extensive levels of developmental planning and harvesting of groundwater resources.