The Belt and Road Initiative provides new opportunities and impetus for the development of higher education in China. In the past 20 years, higher education in China has made great achievements: the scale of higher education talents has increased, the protection of higher education rights has improved, and cooperation and exchanges in higher education have increased. Regarding exchanges and cooperation in higher education in the Belt and Road, China faces unresolved challenges, including the only opportunity for talent training, a complex and changing environment for international cooperation, and broad and unclear institutional norms. Guaranteeing the rule of law is a support and driving force for countries to engage in exchanges and cooperation in higher education within the framework of the Belt and Road. China needs to actively promote the construction of the rule of law under the Belt and Road framework, unambiguously promote the development of higher education through effective laws, and actively promote the civilized process of the rule of law in higher education. Utilizing the rule of law and the rule of law will promote a new stage of higher education reform and build a modern higher education system with Chinese characteristics. Based on the concept of ensuring the proper rule of law to support cooperation and development, various methods should be applied to promote the development of the rule of law, including the formation of the concept of effective law and good governance, the improvement of information and evaluation systems in higher education, and the improvement of the information and evaluation system in higher education.