The study examined the effect of management information systems on the growth of agro-firms in Anambra State. The objectives were to: determine the effect of decision-making information systems on the Return on Investment (ROI) of agro-businesses in Anambra State, Nigeria, and ascertain the extent to which database management systems affect the ROI of agro-businesses in Anambra State, Nigeria. The study adopted a survey research design, with data generated from both primary and secondary sources. The data collection method was a questionnaire, which was randomly administered to staff of selected agro-firms. The population of the study was 6,727, while the sample size was 1,293, out of which 929 questionnaires were retrieved. The hypotheses were tested using the multiple regression analysis method at a 0.05% level of significance. The findings revealed that decision-making information systems had a significant effect on the ROI of agro-businesses in Anambra State, with a t-statistic of 7.743 and a probability value of 0.000. Additionally, database information systems had a significant effect on the ROI of agro-businesses in Anambra State, with a t-statistic of 2.476 and a probability value of 0.013. The study concluded that management information systems have a significant positive effect on agro-firms in Anambra State. It recommended that agricultural firms should invest in advanced decision support tools to aid data-driven decisions that maximize ROI. Furthermore, agro-business managers should focus on optimizing their database information systems to improve data organization and accessibility. Regular maintenance and updates of the database systems are crucial for ensuring accurate and timely information, which can positively impact ROI.