Biomedical informatics is the interdisciplinary field that studies and pursues the effective uses of biomedical data, information, and knowledge for scientific inquiry, problem solving, and decision making, motivated by efforts to improve human health.1 ,2 Not only do biomedical informaticians study and develop theories, methods, and processes for the generation, manipulation, and sharing of biomedical data, but they also investigate how to model and reason on these data in order to effect beneficial change in the healthcare enterprise. In addition, an important aspect associated with developments in this field is the consideration of social and behavioral sciences in the design and evaluation of technical solutions. As a subfield of biomedical informatics, biomedical imaging informatics (BMII) encompasses all of the aforementioned aspects from the perspective of imaging. BMII has emerged as one of the fastest growing research areas in recent years given the evolution of techniques in molecular imaging, anatomical imaging, and functional imaging and advancements in imaging biomarker generation. Developments have also been accelerated by efforts to realize precision medicine,3 which necessitates a multiscale understanding of diseases that integrate insights in areas such as radiology, pathology, and genetics. This focus issue highlights the growing impact of BMII, demonstrating the increasing breadth of imaging modalities (eg, optical, molecular, in addition to traditional diagnostic modalities) and the diversity of specialties that depend on imaging information (eg, dermatology, pathology, surgery). Early efforts in BMII can be traced to the 1980s when the rise in radiological imaging techniques such as CT and MRI necessitated a digital, filmless approach to acquiring and interpreting images. The ability to acquire and distribute images electronically using picture archiving and communication systems (PACS) spawned a variety of applications aimed at improving radiological practice, research, and education. Imaging informatics efforts resulted in the development of specialized standardized … Correspondence to Dr William Hsu, Medical Imaging Informatics (MII) Group, Department of Radiological Sciences, UCLA David Geffen School of Medicine, Los Angeles, CA 90024, USA; willhsu{at}mii.ucla.edu