Brain Activity Information Research Articles

Leao's spreading depression: Synaptic regulation of a diffuse self-oscillating process in the central nervous system

The evidence reviewed in the paper shows that the spreading depression (SD) belongs to the mass of closely packed neurons which can support qualitatively new phenomena occurring at a more primitive level of cellular interaction. The latter becomes prepotent under extreme conditions, overloading the local energy supply and homeostatic mechanisms. The two levels of neural integration, the highly heterogeneous specifically connected synaptic level and the statistically uniform diffusively organized nonsynaptic level, are always present in all forms of brain activity and mutually influence each other. While phenomena mediated by nonsynaptic interaction overrule the synaptic ones under resting conditions, excessive synaptic excitation may either switch the affected brain region from synaptic to nonsynaptic interaction (spike-triggered SD) or assert the synaptic interaction over the nonsynaptic one (functional blockade of SD). Nonsynaptic interaction is an inherent property of brain, an obligatory consequence of the trade-off between maximal packing density and independent function of individual elements of the system which sets definite limits to the maximum activation of synaptic processes, contributes to slow synchronization of neural populations and plays an important role in various instances of brain pathology. The phenomena generated at this level belong to the family of autowaves, share their typical properties and can be described by similar formal rules.

Multi-channel telephone transmission and quantitative on-line analysis of EEG in brain surgery.

During the last ten years clinical neurophysiology has used computerized quantitative methods for analysis. Evaluation of the information previously hidden in the signals from the nervous system offers previously unknown uses and applications for neurosurgery. The quantitative EEG (QEEG) for example may offer more reliable and easily understandable information of brain activity than the conventional analogue EEG. The techniques for QEEG-analysis have now reached such an advanced stage that they extract at the same time more information from the EEG than can be achieved by visual interpretation. The problems of distances between neurosurgical departments and computer centers can be overcome by means of telephone transmitter systems, as has been done in the present study. Patients with epilepsy or brain tumour undergoing surgery were analyzed and monitored with the peroperative tele-QEEG-system. Our experiences were encouraging since the neurophysiological part of the work at the operation unit was reduced considerably thanks to the tele-system. At the same time we obtained easily understandable EEG-information which has never previously been available to us.