This article describes how to use decision support systems as components of an organization's information support in a market economy. The paper identifies a number of problems that can only be solved by sharing modern conceptual provisions of management theory and information technology.The article focuses on the need to create methodological support for the organization of a multilevel system of information flows aimed at supporting decision-making at the enterprise with use. It is necessary to build the scheme of organization of information flows inside the enterprise so that at all stages of decision making the manager could receive information from all contours of information flows inside the enterprise, and not only from the corporate database of the enterprise information system. The combination of existing theoretical and decision-making methods with the correct organization of information is proposed, when different information flows for the manager are formed from the same data set as a result of systematization, allowing to concentrate on finding the optimal alternative for decision-making. Emphasis is placed on the need to create methods for constructing the communication and information structure of decision-making mechanisms. The paper indicates the need to explore the potential potential knowledge that can be gained, to combine them with the existing typology of methods and models, by determining which class of tasks they belong to. The problem of developing methodological foundations for building structures that provide the flow of knowledge flows from data warehouses through KDD systems to the relevant decision support systems at decision points is updated. The key issues that underlie the methodological approach to research and build mechanisms for coordinated development of information resources and decision support systems based on these information resources are outlined. Approaches to solving the presented problems are offered and the requirements for the developed methods are substantiated. Using a methodological approach, specific methods, models and procedures can be developed for different types of enterprises and DSS.