The state of the art and projections related to virtual pedagogical business models developed in the world is presented through a historical, documentary and bibliographical review of emblematic experiences by universities that have implemented these models. In the first part, the models of e-learning in European, American and Colombian universities are analyzed, based on the incorporation of information and communication technologies (ICT) and methodologies used to optimize learning. In the second, the findings are articulated in order to promote innovative ideas for designing an educational virtual online business development. The third component validates the model in two academic years. The study leaves as conclusion that despite the existence of different models of educational virtual business development, the creation of others, with the support of ICT is required, to achieve greater competition, cooperation and connectivity across platforms and mega learning networks. This, to facilitate the construction of new, shared knowledge as contribution to the university in general and, in particular, to the Colombian one, in the development of its immediate context, in front of the globalization of education and commerce.
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