Inform Policy Development Research Articles

Enhancements to the National HIV Surveillance System, United States, 2013-2023.

HIV infection is monitored through the National HIV Surveillance System (NHSS) to help improve the health of people with HIV and reduce transmission. NHSS data are routinely used at federal, state, and local levels to monitor the distribution and transmission of HIV, plan and evaluate prevention and care programs, allocate resources, inform policy development, and identify and respond to rapid transmission in the United States. We describe the expanded use of HIV surveillance data since the 2013 NHSS status update, during which time the Centers for Disease Control and Prevention (CDC) coordinated to revise the HIV surveillance case definition to support the detection of early infection and reporting of laboratory data, expanded data collection to include information on sexual orientation and gender identity, enhanced data deduplication processes to improve quality, and expanded reporting to include social determinants of health and health equity measures. CDC maximized the effects of federal funding by integrating funding for HIV prevention and surveillance into a single program; the integration of program funding has expanded the use of HIV surveillance data and strengthened surveillance, resulting in enhanced cluster response capacity and intensified data-to-care activities to ensure sustained viral suppression. NHSS data serve as the primary source for monitoring HIV trends and progress toward achieving national initiatives, including the US Department of Health and Human Services' Ending the HIV Epidemic in the United States initiative, the White House's National HIV/AIDS Strategy (2022-2025), and Healthy People 2030. The NHSS will continue to modernize, adapt, and broaden its scope as the need for high-quality HIV surveillance data remains.

Exploring climate change discourse on social media and blogs using a topic modeling analysis

Climate change is one of the most pressing global issues of our time, and understanding public perception and awareness of the topic is crucial for developing effective policies to mitigate its effects. While traditional survey methods have been used to gauge public opinion, advances in natural language processing (NLP) and data visualization techniques offer new opportunities to analyze user-generated content from social media and blog posts. In this study, a new dataset of climate change-related texts was collected from social media sources and various blogs. The dataset was analyzed using BERTopic and LDA to identify and visualize the most important topics related to climate change. The study also used sentence similarity to determine the similarities in the comments written and which topic categories they belonged to. The performance of different techniques for keyword extraction and text representation, including OpenAI, Maximal Marginal Relevance (MMR), and KeyBERT, was compared for topic modeling with BERTopic. It was seen that the best coherence score and topic diversity metric were obtained with OpenAI-based BERTopic. The results provide insights into the public's attitudes and perceptions towards climate change, which can inform policy development and contribute to efforts to reduce activities that cause climate change.

NGS panels' capture of biomarkers associated with targeted therapies in clinical trials.

e13508 Background: ASCO and NCCN guidelines strongly encourage participation in clinical trials though participation rates remain low. Although up to 60% of trials require biomarker information as a prerequisite to participation, guidelines are silent on biomarker testing to assess eligibility. To help inform policy development, we analyzed commercially available NGS panels to assess the capture rate of the specific gene variants required for targeted therapies in clinical trials. Methods: Publicly available gene variant information on 12 high volume NGS tissue and plasma commercial assays representative of panel size was accessed. The JAX-CKB database was queried to identify genomic prerequisites in active phase I-III clinical trials; mRNA and protein expression biomarkers were excluded. We used unpaired t-testing to compare the ability of large versus small panels to detect variants required for targeted treatments. (Somatic gene variant annotations and related content have been powered by The Jackson Laboratory Clinical Knowledgebase (JAX-CKBTM)). Results: Overall, 185 genes were linked to eligibility for targeted therapies in clinical trials (Table). Large panel assays (>80 genes) had a higher average capture rate compared to smaller panels, (84% vs. 46%, p value < 0.000002). Similarly, capture rates in select cancers were higher in larger panels: lung (85% vs 59%), breast (92% vs 54%), prostate (86% vs 34%), pancreatic (84% vs 54%), colorectal (88% vs 52%). All results were statistically significant (p < 0.05). Smaller panels were more likely to exclude large genes (e.g. BRCA), genome-wide signatures (e.g. TMB), fusions, and copy number variants. Conclusions: NGS-based panels with more than 80 genes had higher capture rates for biomarkers required for clinical trials of targeted therapies. Clinicians searching for all relevant treatment options for patients should include large genomic sequencing panels to maximize identification of potential clinical trial eligibility. Professional societies and policy makers interested in enhancing clinical trial enrollment rates should consider the panel size-related variability in capture rates of genetic variants when developing recommendations. [Table: see text]

Human Trafficking Hotline Analysis: Insights from the State of Tennessee

ABSTRACT This exploratory study underscores the value of human trafficking hotlines as an important data source for understanding and responding to trafficking at the micro level. Drawing on data from the Tennessee Statewide Human Trafficking Hotline between 2017 and 2021, 2,316 tips were analyzed and revealed a 219% tip increase over five years, with minimal impact noted due to COVID-19. The most common trafficking tips relate to minors (57%), adult sex trafficking (21%), and labor trafficking (4%). Women and minor victims were overrepresented in tips, and only 3% of victims self-reported to the hotline. Tips were concentrated in counties with larger populations; however, tips also indicated human trafficking presence in rural areas. Multiple victims and trafficking suspects were described in 11.5% of cases, and as the number of victims increased, so did the number of suspected traffickers. When suspects operated together, there tended to be one male and one female in the reported trafficking operations. The findings of this study provide insight into the landscape of human trafficking in Tennessee and can inform policy development and enhanced responses by law enforcement and service providers to human trafficking.

Using policy codesign to achieve multi-sector alignment in adolescent behavioral health: a study protocol

BackgroundPolicymaking is quickly gaining focus in the field of implementation science as a potential opportunity for aligning cross-sector systems and introducing incentives to promote population health, including substance use disorders (SUD) and their prevention in adolescents. Policymakers are seen as holding the necessary levers for realigning service infrastructure to more rapidly and effectively address adolescent behavioral health across the continuum of need (prevention through crisis care, mental health, and SUD) and in multiple locations (schools, primary care, community settings). The difficulty of aligning policy intent, policy design, and successful policy implementation is a well-known challenge in the broader public policy and public administration literature that also affects local behavioral health policymaking. This study will examine a blended approach of coproduction and codesign (i.e., Policy Codesign), iteratively developed over multiple years to address problems in policy formation that often lead to poor implementation outcomes. The current study evaluates this scalable approach using reproducible measures to grow the knowledge base in this field of study.MethodsThis is a single-arm, longitudinal, staggered implementation study to examine the acceptability and short-term impacts of Policy Codesign in resolving critical challenges in behavioral health policy formation. The aims are to (1) examine the acceptability, feasibility, and reach of Policy Codesign within two geographically distinct counties in Washington state, USA; (2) examine the impact of Policy Codesign on multisector policy development within these counties using social network analysis; and (3) assess the perceived replicability of Policy Codesign among leaders and other staff of policy-oriented state behavioral health intermediary organizations across the USA.DiscussionThis study will assess the feasibility of a specific approach to collaborative policy development, Policy Codesign, in two diverse regions. Results will inform a subsequent multi-state study measuring the impact and effectiveness of this approach for achieving multi-sector and evidence informed policy development in adolescent SUD prevention and treatment.

Groundwater recharge potential zone modeling in the Wadi Al-Lith Basin, Saudi Arabia

The management of groundwater resources is crucial in arid and semi-arid regions such as Al-Lith Basin, and therefore, the identification of suitable areas for groundwater recharge is important in solving the problem of water scarcity and ensuring the long-term sustainability of aquifers. In this study, the Analytic Hierarchy Process (AHP) technique, in conjunction with GIS, was applied to locate potential zones for groundwater recharge in the Al-Lith basin. The research methodology includes collecting the essential data, including lineament density, slope, rainfall, drainage density, LU/LC, soil, elevation, and TWI. AHP is used to assign relative weights to different qualities, considering their significance in influencing groundwater recharge. The ArcGIS was employed to process and analyze the weighted layers, which resulted in the creation of a comprehensive map illustrating the potential for groundwater recharge. The study results suggested that the Al-Lith Subbasin has several zones that exhibit different levels of groundwater recharge capability. The results obtained from this study indicated that 12.83% of the basin area has significant groundwater recharge potential zones (GWPZ), ranging from high to very high levels. The groundwater recharge potential zones in the basin are categorized as very poor to poor, covering 19.4% of the area, while the moderate groundwater recharge potential zones represent 67.77% of the basin area. The groundwater protection zones were validated using 19 wells distributed across the basin. The validation findings indicate there is an overlap between the GWPZ classes and the wells in the specified location. Overall, the findings of this study can enhance groundwater resource management and inform policy development for targeted interventions aimed at enhancing groundwater recharge.

The functional diversity-productivity relationship of woody plants is climatically sensitive.

Plot-scale experiments indicate that functional diversity (FD) plays a pivotal role in sustaining ecosystem functions such as net primary productivity (NPP). However, the relationships between functional diversity and NPP across larger scale under varying climatic conditions are sparsely studied, despite its significance for understanding forest-atmosphere interactions and informing policy development. Hence, we examine the relationships of community-weighted mean (CWM) and functional dispersion (FDis) of woody plant traits on NPP across China and if such relationships are modulated by climatic conditions at the national scale. Using comprehensive datasets of distribution, functional traits, and productivity for 9120 Chinese woody plant species, we evaluated the distribution pattern of community-weighted mean and functional dispersion (including three orthogonal trait indicators: plant size, leaf morphology, and flower duration) and its relationships with NPP. Finally, we tested the effects of climatic conditions on community-weighted mean/functional dispersion-NPP relationships. We first found overall functional diversity-NPP relationships, but also that the magnitude of these relationships was sensitive to climate, with plant size community-weighted mean promoting NPP in warm regions and plant size functional dispersion promoting NPP in wet regions. Second, warm and wet conditions indirectly increased NPP by its positive effects on community-weighted mean or functional dispersion, particularly through mean plant size and leaf morphology. Our study provides comprehensive evidence for the relationships between functional diversity and NPP under varying climates at a large scale. Importantly, our results indicate a broadening significance of multidimensional plant functional traits for woody vegetation NPP in response to rising temperatures and wetter climates. Restoration, reforestation actions and natural capital accounting need to carefully consider not only community-weighted mean and functional dispersion but also their interactions with climate, to predict how functional diversity may promote ecosystem functioning under future climatic conditions.

Understanding Local Perceptions of Impacts of Climate Change Among Small-Scale Sama-Bajau Fishers and Their Patrons in Wakatobi National Park, Indonesia

Understanding similarities and differences in perceptions of climate change impacts aids in the development of co-adaptation strategies. While there has been extensive research on perceptions of climate change impacts among small-scale fishing communities, studies focusing on the perspectives of maritime tribes, fishers, and their respective patrons in small islands are notably scarce. The current study compares the perceptions of climate change impacts by Sama-Bajau fishers and their patrons in Wangi-Wangi Island of Wakatobi National Park. Data was collected through in-depth interviews, casual conversations, field observation, and secondary data analysis between August 2021 and February 2022. Findings revealed that although fishers and their patrons similarly perceived some impacts, they perceived others differently because of distinct sources of information and experience. Fishers, middlemen and employees of fishing companies perceived the impacts through personal observation and information from other fishers while government and non- governmental officers relied on scientific reports and personal experience in addition to the information given by the fishers. Future research should explore context-specific coping, adaptation and transformation measures based on local perceptions and diverse patron-client relationships to inform policy development.

Breast cancer screening motivation and behaviours of women aged over 75 years: a scoping review

BackgroundThis scoping review aimed to identify and present the evidence describing key motivations for breast cancer screening among women aged ≥ 75 years. Few of the internationally available guidelines recommend continued biennial screening for this age group. Some suggest ongoing screening is unnecessary or should be determined on individual health status and life expectancy. Recent research has shown that despite recommendations regarding screening, older women continue to hold positive attitudes to breast screening and participate when the opportunity is available.MethodsAll original research articles that address motivation, intention and/or participation in screening for breast cancer among women aged ≥ 75 years were considered for inclusion. These included articles reporting on women who use public and private breast cancer screening services and those who do not use screening services (i.e., non-screeners).The Joanna Briggs Institute (JBI) methodology for scoping reviews was used to guide this review. A comprehensive search strategy was developed with the assistance of a specialist librarian to access selected databases including: the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline, Web of Science and PsychInfo. The review was restricted to original research studies published since 2009, available in English and focusing on high-income countries (as defined by the World Bank). Title and abstract screening, followed by an assessment of full-text studies against the inclusion criteria was completed by at least two reviewers. Data relating to key motivations, screening intention and behaviour were extracted, and a thematic analysis of study findings undertaken.ResultsA total of fourteen (14) studies were included in the review. Thematic analysis resulted in identification of three themes from included studies highlighting that decisions about screening were influenced by: knowledge of the benefits and harms of screening and their relationship to age; underlying attitudes to the importance of cancer screening in women's lives; and use of decision aids to improve knowledge and guide decision-making.ConclusionThe results of this review provide a comprehensive overview of current knowledge regarding the motivations and screening behaviour of older women about breast cancer screening which may inform policy development.

The economic burden of obesity in 2024: a cost analysis using the value of a statistical life

ABSTRACT In 2024, the economic burden of obesity remains a paramount global concern due to its escalating prevalence, which imposes substantial pressures on healthcare systems, hampers productivity, and detracts from the quality of life. This paper explores the evolving obesity epidemic and its economic ramifications, emphasizing the necessity of precise measurement techniques to inform policy development and resource allocation. The study adopts the Value of a Statistical Life (VSL) methodology, which provides an innovative approach to quantifying the monetary value of mortality risk reductions associated with obesity-related health conditions. This approach surpasses traditional cost analyses that focus on direct medical expenses by incorporating a willingness-to-pay metric, reflecting societal preferences for risk mitigation. Our findings present a comprehensive cost analysis for the year 2024, utilizing both total deaths and Disability-Adjusted Life Years (DALYs) within the VSL framework, highlighting the importance of such an approach in understanding the full economic impact of obesity on a global scale.

Unlocking Patient Voices: Advancing Physical Therapist Practice With Discrete Choice Experiments.

As health care moves away from volume-based to value-based delivery, the role of the patient in determining value in health care is now paramount. Thus, health care should be aligned with what matters most to patients. Ascertaining patient preferences is therefore critical if we are to provide patients with care that is meaningful to them. However, preferences are difficult to measure and traditional methods of preference measurement in physical therapy face challenges when attempting to measure such. This perspective makes a case for greater use of the discrete choice experiment (DCE) in physical therapy as a research method to measure patient preferences. The DCE is a research method used to elicit preferences for services or goods. This article addresses the importance of eliciting patient preferences as part of person-centered care in the value-based space, the challenges faced in preference measurement in physical therapy, and how the DCE can alleviate some of those challenges. It also provides examples of the DCE in health care and suggests ways in which it can be effectively used in physical therapist practice to improve the delivery of meaningful rehabilitation services to patients. Implementing greater use of the DCE in physical therapy can improve person-centered physical therapist service delivery and inform policy development that creates cost-effective care which is meaningful to patients. It can further help to highlight the value of physical therapy to population health, and to policy makers as health care moves toward more value-based models.

Sustaining professionalism: Teachers as co‐enquirers in curriculum design

AbstractIn England, the development of teachers' curriculum design capabilities has been identified as a ‘challenge remaining’ (Department for Education [DfE]. (2022). Opportunity for all: Strong schools with great teachers for your child. https://www.gov.uk/government/publications/opportunity‐for‐all‐strong‐schools‐with‐great‐teachers‐for‐your‐child). A recent White Paper (Department for Education [DfE]. (2022). Opportunity for all: Strong schools with great teachers for your child. https://www.gov.uk/government/publications/opportunity‐for‐all‐strong‐schools‐with‐great‐teachers‐for‐your‐child) offered access to a publicly funded online platform as a solution. Drawing on Stenhouse's concepts of teachers as researchers and curriculum as an inquiry process, this article argues that such a policy initiative restricts both curriculum and professional development. An alternative approach to curriculum design, one based on Stenhouse's conception of the iterative development of teachers' professional and curriculum knowledge is profiled. In this article, we, as four teacher‐researchers, analyse a project which featured the Curriculum Design Coherence (CDC) model. We share insights gained from our involvement, both in relation to our professional learning and the impact of our curriculum design work on our pupils. We argue that the ‘othering’ of teachers in research contributes towards the under valuing of practice‐informed evidence in policy making. We draw on the work of Lawrence Stenhouse to inform a different means of generating educational research evidence, one that sustains teacher‐researchers through engagement with principles and concepts so as to inform policy and curriculum development.

Health sciences students' perspectives on online teaching and learning: Extending the implications beyond the COVID‐19 pandemic

AbstractDigital transformation in education and relevant calls for action are recognised global priorities aimed to support education and training in the digital age. The experiences from the emergency remote teaching during the COVID‐19 pandemic and recent research findings reveal relevant advantages, challenges, as well as different students and teaching staff perspectives which should be carefully considered and integrated into institutional strategies and policies to improve and enrich students’ learning experience. The present study aimed to explore health sciences students' perspectives on online teaching and learning (T&L) in four domains—Satisfaction, Motivation, Interaction and Challenges, and to identify the preferred T&L models or tools. A total of 1,041 responses were collected, including 476 dental medicine (45.7%), 399 pharmacy (38.3%), and 166 medical students (15.9%). Overall Satisfaction was quite high (4.0 ± 1.2; out of 5), followed by satisfactory Interaction (3.4 ± 1.4), whereas Motivation was quite low on average (3.0 ± 1.5). Challenges in online T&L were not markedly expressed (3.0 ± 1.6). The majority of students (46.6%) opted for the blended model as the preferred T&L model. Moodle lessons were perceived as the most useful online T&L tool (45.5% of students), followed by video materials (32.2%). Other T&L tools which require more active student's role, such as short test/quiz, and group or team assignment were declared as less favourable. The findings from the current study may contribute to raising the awareness of academic staff and higher institutions management about the student attitudes and needs related to online T&L and inform institutional planning, decision‐making and policy development.

Rape Victims' Perceptions of Quality of Encounters With the Swedish Police.

This study focused on raped women's perceptions of their encounters with Swedish police, with a specific focus on quality of encounters, trust, questions asked during police interviews, and perceptions of justice. One hundred and six rape victims, 74 of whom had reported to the police, answered a web-based questionnaire. Results show that where officers explained their line of questioning the perceived intrusiveness of the questioning was lower, as was the level of perceived victim-blaming. Higher quality police encounters were associated with higher trust in the legal system and in police work, and with higher levels of received justice. Findings highlight the importance of trauma-informed policing as a response to sexual assault and provide insights which might help inform policy and practice developments, both in Sweden and more generally.

Health literacy and household financial loss on malaria treatment for children under five in Ghana: a patients' perspective.

Inadequate health literacy increases medical costs and leads to poor health outcomes. However, there is a paucity of empirical evidence of such associations in sub-Saharan Africa. This study investigates how the household cost of malaria in children under five in Ghana varies based on different levels of health literacy. A cross-sectional survey involving 1270 caregivers of children under five was conducted. The survey included health literacy questionnaire and several pieces of sociodemographic and behavioural variables. We created seven caregiver health literacy profiles by scoring nine dimensions. The mean total cost for managing malaria among respondents was US$20.29 per episode. The total household cost for caregivers with high health literacy (Profile 1) (US$24.77) was higher than all other profiles, with the lowest cost (US$17.93) among the low health literacy profile (Profile 6). Compared with Profile 4, caregivers with high health literacy (Profile 1) spent more on managing malaria in children, while those with the lowest health literacy (Profile 7) spent less. The current study presents a snapshot of malaria treatment costs, and argues that low health literacy may lead to increased costs due to possible reinfections from delayed healthcare use. There is a need for longitudinal studies to understand causal relationship between health literacy and household expenses on malaria treatment to inform policy development and interventions. This study explores the impact of caregiver health literacy levels on the cost of managing malaria incidents in children under five in Ghana. High health-literate caregivers incurred the highest total household cost at US$24.77, with US$17.93 incurred by lower health-literate caregivers per malaria episode.

Physical activity and mental health in individuals with multimorbidity during COVID-19: an explanatory sequential mixed-method study

ObjectiveTo understand the physical activity and mental health of individuals living with long-term conditions during the COVID-19 pandemic.DesignA sequential explanatory mixed-methods study with two phases: phase 1: quantitative survey and...

Effects of Environmental Enrichment on Stress and Welfare in Laboratory Animals

Purpose: The general purpose of this study was to examine the effects of environmental enrichment on stress and welfare in laboratory animals.
 Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
 Findings: The findings reveal that there exists a contextual and methodological gap relating to the effects of environmental enrichment on stress and welfare in laboratory animals. Preliminary empirical review revealed that that enriching their living environments significantly improved their well-being. They found that interventions such as physical, social, cognitive, and sensory enrichment reduced stress levels, promoted natural behaviors, and enhanced cognitive function. Tailoring enrichment programs to specific species' needs and considering factors like environmental complexity and novelty proved crucial. Moreover, these interventions not only benefited animal welfare but also improved research outcomes by reducing stress and enhancing the validity of preclinical studies. Overall, the research underscored the importance of implementing evidence-based enrichment strategies to ensure the ethical treatment of laboratory animals and enhance the reliability of scientific research.
 Unique Contribution to Theory, Practice and Policy: The Biophilia Hypothesis, Optimal Stimulation theory and Stress Inoculation theory may be used to anchor future studies on stress and welfare in laboratory animals. The study made significant contributions to theory, practice, and policy in the field of laboratory animal welfare. It provided valuable insights into the underlying mechanisms of environmental enrichment's influence on animal well-being, contributing to existing theoretical frameworks such as the Biophilia Hypothesis, Optimal Stimulation Theory, and Stress Inoculation Theory. Additionally, the study offered practical recommendations for implementing evidence-based enrichment programs tailored to the needs of different animal species. These findings informed policy development by guiding the establishment of standards for enrichment in laboratory animal facilities, enhancing the protection and welfare of laboratory animals across institutional and national levels.
 Keywords: Environmental Enrichment, Laboratory Animals, Stress, Welfare, Mechanisms, Biophilia Hypothesis, Optimal Stimulation Theory, Stress Inoculation Theory, Implementation, Standards, Well-Being

Influence of Cultural Differences on Global PR Campaigns

Purpose: The aim of this study was to investigate how these cultural differences influence the strategies, messages, and implementation of global PR campaigns.
 Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
 Findings: The findings reveal that there exists a contextual and methodological gap relating to cultural differences on global PR campaigns. Preliminary empirical review revealed that cultural sensitivity and adaptation are crucial for crafting effective PR strategies across diverse audiences worldwide. By analyzing various cultural dimensions, communication styles, and adaptation strategies, the study revealed the necessity of tailoring campaigns to meet the unique cultural preferences and values of target audiences. Furthermore, it highlighted the importance of cultural intelligence among PR practitioners in navigating global communication challenges successfully. The findings underscored the need for ongoing research, audience analysis, and training initiatives to inform and enhance PR campaign strategies. Overall, the study emphasized that embracing cultural diversity is essential for achieving communication objectives and positioning brands as credible and relatable in the global marketplace.
 Unique Contribution to Theory, Practice and Policy: The Hofstede's Cultural Dimensions theory, Hall's High-Context vs. Low-Context Communication and Trompenaars and Hampden-Turner's Cultural Dimensions may be used to anchor future studies on cultural differences on global PR campaigns. The study provided valuable recommendations that contributed to theory, practice, and policy in the field of public relations. It suggested integrating cultural dimensions theories into PR campaign development, emphasizing the importance of conducting thorough cultural analyses and audience research, and promoting cross-cultural communication skills among PR professionals. These recommendations enhanced our understanding of the complex interplay between culture and PR practices, empowered PR practitioners to navigate cultural differences effectively, and informed policy development to foster a more ethical and inclusive PR industry globally.

Tracing and source fingerprinting of metals from the southern coastal sediments in Bangladesh.

Trace element pollution from anthropogenic sources is increasingly widespread. This pollution in terrestrial environments threatens agricultural crop production, while in aquatic environments, it threatens fish cultivation. The contamination of these crucial food sources raises significant concerns regarding food safety, security, and its potential adverse effects on human health. Coastal areas are particularly vulnerable to heavy metal pollution due to their proximity to industrial and urban centres, as well as their susceptibility to contamination from marine sources. In attempting to identify the sources of heavy metals (As, Cu, Cr, Cd, Fe, Hg, Mn, Ni, Pb, and Zn) and measure their contributions, we collected soil samples from thirty sites along the three coastal districts (Patuakhali, Barguna, and Bhola) in Bangladesh. Using atomic absorption spectroscopy, heavy metal concentrations in soil samples were measured and three receptor models (PMF, PCA-MLR, and UNMIX) were applied to detect their sources. Pairwise correlation analysis of metal concentrations in 30 sites across 3 coastal districts showed all possible patterns, including both significant and insignificant positive and negative relationships between different metals, except for As and Hg which did not display any significant relationships with other metals. The concentrations of Cu, Fe, Mn, Ni, and Zn exceed the US-EPA sediment quality standard. The applied PCA-MLR, PMF, and UNMIX models identified several sources of heavy metal contamination, including (i) mixed anthropogenic and natural activities: contribution of 59%, 37%, and 43%, and (ii) vehicle emissions: contribution of 23%, 26% and 29%. The recognized metal sources should be prioritised to avoid the discharge of poisonous pollutants from anthropogenic factors and any possible future exposure. This study's findings have implications for ongoing monitoring and management of heavy metal contamination in coastal environments to mitigate potential health and ecological impacts and can inform policy development and management strategies.

Integrating genomics into Canadian oncology nursing policy: Insights from a comparative policy analysis.

To learn from two jurisdictions with mature genomics-informed nursing policy infrastructure-the United States (US) and the United Kingdom (UK)-to inform policy development for genomics-informed oncology nursing practice and education in Canada. Comparative document and policy analysis drawing on the 3i + E framework. We drew on the principles of a rapid review and identified academic literature, grey literature and nursing policy documents through a systematic search of two databases, a website search of national genomics nursing and oncology nursing organizations in the US and UK, and recommendations from subject matter experts on an international advisory committee. A total of 94 documents informed our analysis. We found several types of policy documents guiding genomics-informed nursing practice and education in the US and UK. These included position statements, policy advocacy briefs, competencies, scope and standards of practice and education and curriculum frameworks. Examples of drivers that influenced policy development included nurses' values in aligning with evidence and meeting public expectations, strong nurse leaders, policy networks and shifting healthcare and policy landscapes. Our analysis of nursing policy infrastructure in the US and UK provides a framework to guide policy recommendations to accelerate the integration of genomics into Canadian oncology nursing practice and education. Findings can assist Canadian oncology nurses in developing nursing policy infrastructure that supports full participation in safe and equitable genomics-informed oncology nursing practice and education within an interprofessional context. This study informs Canadian policy development for genomics-informed oncology nursing education and practice. The experiences of other countries demonstrate that change is incremental, and investment from strong advocates and collaborators can accelerate the integration of genomics into nursing. Though this research focuses on oncology nursing, it may also inform other nursing practice contexts influenced by genomics.