Biodegradable colloidosomes have attracted increasing attention for their applications to enhance the efficacy and reduce wastage of pesticides in agriculture. In this study, we present a continuous and highly efficient method for production of starch colloidosomes. The starch particles with an average particle size of 230.2 nm and good dispersibility were prepared using surface modification technology, and then used as environment-friendly shell materials to form self-assembled starch colloidosomes using spray drying technology. The influences of inlet temperature, feed rate and air flow rate on the morphologies of colloidosomes were also studied. This strategy enables the construction of starch colloidosomes with uniform spherical morphology and controllable pore sizes under different pH, and can be used for pesticide encapsulation. After loading pyraclostrobin (PYR), the regular spherical colloidosomes not only achieve a small mean diameter of 2.35 µm, but also realize a high encapsulation efficiency of 82 %. The release performance of PYR has an obvious pH response and follows the segmented Ritger-Pepapes model of sustained-release. The colloidosomes were used to prevent the photodegradation of pesticides. The PYR loaded colloidosomes exhibit excellent UV resistance with a retention rate of 72.7 %. In addition, the loading of Fe3O4 nanoparticles and the embedding of carbon dots were also explored.