Purpose: This study was conducted to identify the main factors that influence college students’ perceived stress and smartphone addiction in adjusting to college life. Methods: Data was collected from 170 enrolled college students located at D. city. Using the SPSS 26.0 program, the collected data was analyzed through a t-test, ANOVA, Pearson’s correlation, and multiple regression analysis. Results: Consequently, among the general characteristics, grade(F=3.537, p=.016) and satisfaction with college major(F=17.631, p<.001) revealed a significant difference in adjusting to college life. Additionally, it was found that as perceived stress( β=-.552, p<.001) is high and smartphone addiction is the level of high risk( β=-.135, p=.017), the level of adjustment to college life decreases. These variables explain 49.9% of adjustment to college life. Conclusion: Therefore, to increase college students’ adjustment to college life, measures should be prepared to help promote self-growth by allowing them to recognize and control the degree of stress and level of smartphone addiction for themselves.