It has been shown that the localization of deformation can be induced by a change in strain path. Changes in strain path can also influence evolution of deformation texture. However, the correspondence between microstructure and crystallographic texture evolution in metals under complex loading paths has been generally neglected in studies of plastic deformation. The change in microstructure found recently in austenitic stainless steel single crystals with the initial orientation (110)[001] subjected to cross-rolling suggested that the analogous experiment on crystals with higher stacking fault energies would shed new light on the influence of strain path changes on microstructure and texture development. The aim of the present work is to examine the structural and textural changes induced by changes in the direction of plastic flow in select copper single crystals, i.e., crystals deforming by dislocation glide. In contrast to other studies on changes in strain path, the present study considers the effect of secondary deformation mode on resulting microstructure.