Hot peppers are important vegetable crops widely grown in Ethiopia. Investigation into the economic, nutritive and therapeutic purposes of the pepper plant is extremely limited. Thus, a field trial was piloted to assess the influence of NPS (compound fertilizer containing three important plant nutrients of nitrogen, phosphate, and sulphur with the ratio of 19% N, 38% P2O5, and 7% S) and farmyard manure (FYM) fertilizer on hot pepper at the Dambi Dollo University research field for two consecutive years (2020 and 2021) under rain fed. The finding was systematized in a Randomized Complete Block Design (RCBD) with three repetitions and variety of Marako Fana hot pepper was assessed. NPS fertilizer at four level (0, 100, 200, 300 kg N ha-1) and four FYM levels (0, 2.5, 5, 7.5, 10 t ha-1) were owed to the study area and a total of 20 treatments. The research results revealed that FYM and NPS mineral fertilizer interacts to affect positively (P<0.05) maximum parameters without unmarketable harvest, which was influenced through the single effect of NPS and FYM. The highest marketable pod yield (2.28 t ha-1) and total pod harvest (2.72 t ha-1) was recorded through NPS rates of 100 kg ha-1 applied with 5 t ha-1 of farmyard manure. Consequently, it is likely to determine that hot pepper farmers can use NPS mineral fertilizer rate of 100 kg ha-1 with 5 t ha-1 of FYM that would expand yield of the hot peppers in the study area with similar agro-ecological conditions.
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