This research investigates the intricate relationships among ethical climate, workplace spirituality, organizational justice, organizational citizenship behavior (OCB), and workplace deviant behavior within the context of higher education institutions in Pakistan. The study proposes and tests a comprehensive model, exploring direct relationships and the mediating role of OCB. The hypotheses posit significant associations between ethical climate, workplace spirituality, organizational justice, and both organizational citizenship behavior and workplace deviant behavior. Furthermore, the research examines the mediating effects of organizational justice on the relationships between ethical climate, workplace spirituality, and workplace deviant behavior. Drawing on a sample of 259 teachers from various public and private universities in Pakistan, the study contributes to filling existing gaps in the literature, particularly in the context of developing nations. The methodology employs a correlational research design, utilizing a survey questionnaire with Likert-type scales. Data analysis is conducted through Partial Least Squares Structural Equation Modeling (PLS-SEM), allowing for a nuanced examination of relationships and mediating effects. The results indicate significant direct relationships between ethical climate and workplace deviant behavior, as well as organizational justice and deviant behavior. Ethical climate also positively relates to organizational citizenship behavior, as does organizational justice. Workplace spirituality, however, does not exhibit a significant relationship with workplace deviant behavior or organizational citizenship behavior. The findings further reveal the mediating role of organizational citizenship behavior in the relationships between ethical climate and workplace deviant behavior, as well as organizational justice and workplace deviant behavior. Overall, this research contributes to the understanding of ethical and behavioral dynamics in organizational settings, particularly in the unique context of higher education institutions in Pakistan.