ABSTRACT This study highlights the necessity of drawing more attention to core-technology competence, a specific dimension of firm innovation competence, when examining the overall supplier concentration-innovation relationship to respond to the unprecedented challenges in the supply chain and technological advancement. Still, the mechanism of strategic aggressiveness and the conditioning role of environmental uncertainty are not well explored in this concern. Therefore, it is necessary to combine these factors to analyse. Using the data from Chinese manufacturing firms from 2012 to 2020 and based on resource dependence theory, we construct a panel data model to conduct empirical analysis and obtain the following results: supplier concentration can hinder firms’ core-technology competence; supplier concentration would constrain firms’ strategic aggressiveness, subsequently impairing core-technology competence; while supplier concentration can limit strategic aggressiveness, high environmental uncertainty can mitigate these negative effects. The findings are beneficial for firms to cope with current challenges and enhance core-technology competence based on the global supply chain crisis and environmental uncertainty.