Abstract Background Following the COVID-19 outbreak, people have been fighting the pandemic for 2 years. Throughout the course of civilization, human beings are never the party of compromise. After a period of exploration, people's lives began to undergo adaptive changes. At the same time, the exposed problems are also becoming increasingly serious. The new virus has forced people to adopt quarantine and control to avoid its spread in the population. As is known, medical studies are notoriously difficult and challenging; therefore, whether such a situation would have an impact on medical freshmen led to the study. Methods Based on the literature review, factor analysis, and structural equation model, we explore the relationship between learning cognition, learning behavior, and learning environment during online learning for medical freshmen. Learning behaviors include interactive communication, self-discipline mechanism, and learning in class and after class. The learning environment includes the learning environment and the network environment. Findings It was found that learning behavior has a significant positive influence on learning cognition. Although the direct influence of the learning environment on learning cognition is not significant, it can positively influence learning behavior and then promote learning cognition through the masking effect. Suggestions This paper suggests strengthening the platform construction and network support, improving the online teaching ability of college teachers, and standardizing the corresponding teaching reward and punishment system. The medical information 'learning environment' should be improved, which will then stimulate the learning enthusiasm of the medical freshmen. The monitoring and improvement of students' psychological conditions should be strengthened. In this way, online teaching can be carried out steadily under a more perfect system.
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