Abstract. Introduction. Etiology of benign non-neoplastic liver lesions is quite diverse. They are usually represented by both purulent inflammatory and parasitic foci. Non-tumor lesions are characterized by severe course and by difficulties in diagnosing and managing the patients. Aim. The aim of the study was to analyze the characteristics of the diagnostic search and surgical treatment of patients with non-neoplastic liver lesions, based on the experience of our clinic.Materials and Methods. Treatment cases of 34 patients with non-tumor liver foci were analyzed by our team. We studied the steps of diagnosing non-neoplastic liver lesions and the surgical approaches to treatment, based on the etiology and nature of each liver lesion. Results and Discussion. In 79% (n=27) of all cases, focal diseases have been observed over the last three years. Etiologically, liver segment lesions were different. In 53.6% (n=18) of cases, 2-3 segments were affected simultaneously. In 11.7% (n=4) of cases, bilobar liver damages were detected. In liver abscesses, minimally invasive surgical approaches were used predominantly; in 70.9% (n=24) of cases, percutaneous abscess drainage was performed under ultrasound navigation. In 8.8% (n=3) of cases, abscess was redrained with a catheter; in 5.8% (n=2) of cases, abscess cavity was evacuated by puncturing. In cholangiogenic abscesses, the leading purpose was to resolve the hypertension of the bile ducts, followed by the abscess drainage. Smaller cholangiogenic abscesses were managed conservatively. Mortality was 5.8%. (n=2) in all groups of interest. Conclusion. In diagnosing the non-neoplastic liver lesions, an integrated approach is required, considering the present history and laboratory findings. In this case, the diagnosis standard is the use of ultrasound technology and computed tomography scans, while magnetic resonance imaging is indicated for diagnosing pathological factors relating to bile ducts. Surgical approaches are dependent on the nature of the pathological process. Minimally invasive technique under ultrasound navigation is the key technique for treating patients with purulent inflammatory liver lesions.