Inflammatory Fibrous Hyperplasia Research Articles

The relationship of oral mucosal lesions and removable prostheses: Quantitative and qualitative study

Background/Aim: The aim of this study was to determine the development and distribution of denture-related oral mucosal lesions in patients using removable prosthesis by using quantitative and qualitative research methods. Material and Methods: A 21-item structured questionnaire form was used. Then, patients were evaluated for the presence and types of oral lesions. In the qualitative phase of the study, two focus group interviews were conducted with volunteers among participants of the quantitative part. The quantitative data were first evaluated by the Kolmogorov-Smirnov test for normal distribution. Chi-square test, Mann Whitney U test, t-test and logistic regression were used for statistical evaluation. Qualitative data analysis was manually performed by the content analysis method. Results: This study included 171 subjects. When the participants were classified as lesion and non-lesion groups, cigarette use and duration of prosthesis use were higher in patients with lesions. Denture-related lesions occurred in 46.2% of the participants; prosthetic stomatitis in 23.9% of the denture-related lesions, traumatic ulcer in 12.9%, epulis fissuratum in 9.9%, and angular cheilitis in 5.8%. Of the participants with lesions 72% (n=57) had a single lesion, while 28% (n=22) had multiple lesions. The duration of prosthesis use was longer in patients with lesions (p=0.022). The main themes determined in the qualitative stage were identified as "views on prosthesis use", "features related to prosthesis care", "information sources on prosthesis" and "proposals of participants". Conclusions: Current study shows that denture-related lesions are very common. Patients should be informed in detail and adequately by physicians and specialized nurses in this regard at every stage of treatment. A universal protocol will be very helpful to ensure that patients are provided with all necessary information about wearing dentures, their maintenance and the importance of regular check-ups. Informative meetings should be organized for wider patient groups in which patients may also interactively participate in, and studies to increase oral health literacy should be conducted. The cross-sectional assessment is not enough for risk assessment due to its nature and only declaration based assessment might miss the relations. Follow-up studies combined with qualitative studies with different approaches are needed.

Oral health condition of elderly people with Parkinson disease

The oral hygiene of individuals with Parkinson disease (PD) is markedly impaired by difficulties in toothbrushing due to motor impairment and tremors. Additionally, it appears that other features associated with PD have an impact on the quality of oral health. Objective: this cross-sectional observational study characterized the oral health condition of individuals with PD. Methods: fifty individuals with PD, aged 53 to 94 years, users of medication for such condition were examined. The research participants had their oral cavities examined to assess prosthetic use and need; index of Decayed, Missing and Filled Teeth (DMFT); Community Periodontal Index (CPI); Periodontal Attachment Loss (PAL); and oral mucosa. In addition, a questionnaire was applied to obtain personal data, general health, and oral health. The data were analyzed using descriptive statistics. Results: a high prosthetic use was observed in the upper arch (92%), while the lower arch revealed high prosthetic need (66%). The DMFT index showed a high number of missing teeth, CPI showed a prevalence of 43% of dental calculus, and PAL revealed 28% of attachment loss of 4-5 mm. The most frequent findings in the assessment of oral mucosa were denture stomatitis and inflammatory fibrous hyperplasia. Conclusion: PD patients refer xerostomia and present high number of missing teeth, a minority of healthy teeth, and oral lesions, representing a target population for specialized oral health care.

Prevalência e caracterização das lesões orais na Clínica de Estomatologia da Policlínica Piquet Carneiro – Estudo Retrospectivo de 12 anos

Objetivo: avaliar a prevalência dos principais tipos de lesões submetidas à biópsia e identificar o perfil dos pacientes atendidos no ambulatório de Estomatologia da Policlínica Piquet Carneiro (PPC/UERJ, Rio de Janeiro) no período compreendido entre 2000 e 2012. Material e Métodos: estudo transversal e retrospectivo em que prontuários de 2078 pacientes foram avaliados e dados referentes às doenças, idade, gênero, cor da pele e localização anatômica das lesões foram coletados e analisados de forma descritiva. Resultados: 69% dos pacientes (1441 casos) obtiveram o diagnóstico conclusivo através de exame histopatológico, ao passo que 31% (637 casos) obtiveram um laudo histopatológico descritivo. Dos casos com diagnóstico histopatológico conclusivo, 58% eram mulheres, 31% homens e em 11% o sexo não foi informado. A média de idade da população estudada foi de 50,63 anos e em 58% dos casos os pacientes eram leucodermas. O maior número de lesões foram as do grupo dos processos proliferativos não-neoplásicos, sendo a hiperplasia fibrosa inflamatória (30,1%) a mais prevalente. Conclusão: o perfil epidemiológico do paciente atendido no período estudado foi composto predominantemente por mulheres com mais de 50 anos de idade e a lesão oral mais prevalente foi a hiperplasia fibrosa inflamatória. Este estudo reforça a importância do papel da análise histopatológica como método auxiliar de diagnóstico e que possibilita a elaboração de estratégias específicas para prevenção e detecção precoce das doenças orais mais frequentes na população.

RETROSPECTIVE LONGITUDINAL STUDY OF ORAL DISEASES IN PATHOLOGIC ANATOMY SERVICE IN THE PERIOD FROM 1999 TO 2016

Objective It was evaluated the epidemiologic profile and conducted a retrospective study of the main oral diseases diagnosed in pathology service, during the years of 1999 to 2016. Study Design Considering the reports issued, the frequency of oral lesions was assessed using the following characteristics: age, sex, ethnicity, location of the lesion, and histopathologic diagnosis. The patients selected to participate were contacted and invited, so that they could undergo an intraoral and extraoral physical examination, to verify the health of oral structures and the evolution of the treatment given to the lesion diagnosed by means of the anatomopathologic examination performed. Results The female sex is the most affected in regard to oral lesions, with a more frequent occurrence in the fourth and fifth decades of life. The most predominant anatomic location of the lesions was the lower lip, and the fibrous inflammatory hyperplasia is the most prevalent disease. Conclusions These results corroborate with those found in the literature, citing trauma as the main etiologic factor. According to the examination of follow-up care, 14 patients presented recurrence of the lesion, in a total of 44 patients who attended. Fibrous inflammatory hyperplasia was the oral lesion that presented a higher prevalence of recurrence. It was evaluated the epidemiologic profile and conducted a retrospective study of the main oral diseases diagnosed in pathology service, during the years of 1999 to 2016. Considering the reports issued, the frequency of oral lesions was assessed using the following characteristics: age, sex, ethnicity, location of the lesion, and histopathologic diagnosis. The patients selected to participate were contacted and invited, so that they could undergo an intraoral and extraoral physical examination, to verify the health of oral structures and the evolution of the treatment given to the lesion diagnosed by means of the anatomopathologic examination performed. The female sex is the most affected in regard to oral lesions, with a more frequent occurrence in the fourth and fifth decades of life. The most predominant anatomic location of the lesions was the lower lip, and the fibrous inflammatory hyperplasia is the most prevalent disease. These results corroborate with those found in the literature, citing trauma as the main etiologic factor. According to the examination of follow-up care, 14 patients presented recurrence of the lesion, in a total of 44 patients who attended. Fibrous inflammatory hyperplasia was the oral lesion that presented a higher prevalence of recurrence.

INFLAMMATORY FIBROUS HYPERPLASIA: PREVALENCE OF DIAGONOSED CASES IN A UNIVERSITY AND CASE REPORTS

Inflammatory fibrous hyperplasia (IFH) is a benign proliferative lesion that arises in the oral cavity from chronic, low-intensity trauma. The aim of this study is to survey the rate of appearance of diagnosed IFH cases in the department of stomatology of a university and to demonstrate 3 cases of inflammatory fibrous hyperplasia. We use as an aid for diagnosis: excisional biopsy and histopathologic exam. The cases led us to a surgical treatment of total removal of the lesion and suspension of irritant agents that culminated in an excellent postoperative period and absence of relapses.

ELEVATED LEVEL OF IL-2, IL-5 AND TNF-α ARE ASSOCIATED WITH PROLIFERATIVE VERRUCOUS LEUKOPLAKIA

Objective This study aims to investigate whether levels of multiples inflammatory mediators differed among patients with proliferative verrucous leukoplakia (PVL), oral leukoplakia (OL), oral squamous cell carcinoma (OSCC), and inflammatory fibrous hyperplasia (control group). Study Design The study includes frozen biopsy fragments of 12 PVL, 13 OL, 8 OSCC, and 7 control patients. A total of 26 mediators for the characterization of the Th1 / Th2 / Th9 / Th17 / Th22 / Treg cell subtypes and CD8+ T-cell were analyzed using Luminex system. Results The levels of IL-4 and IL-9 were significantly higher in PVL (P = .001), OL (P = .001) and OSCC (P = .003) patients compared to the control group, while the levels of IL-2, IL-5 and TNF-α were significantly higher in PVL compared to the OL and OSCC groups. Conclusions Our data suggest that elevated levels of IL-4 and IL-9 may be associated with OSCC and potentially malignant disorders, indicating the possible participation of Th-2 and Th-9 cell subtypes in these conditions. Furthermore, elevated TNF-α levels observed in PLV group suggest an inflammatory process that possibly benefits tumor development. This could be a significant tool for distinguish and monitoring patients with PVL.

SPINDLE CELL LIPOMA OF THE ORAL CAVITY: CASE REPORT OF AN UNCOMMON AND DISTINCT VARIANT OF LIPOMA

Spindle cell lipoma (SCL), an uncommon histologic variant of lipoma, is a benign tumor that often occurs in the posterior neck or shoulder with rare occurrence in the oral cavity. It comprises about 1.6% of intraoral lipomatous tumors. The aim of the case report is to present the histopathologic features of a SCL. A 60-year-old woman with noncontributory medical history was examined for an asymptomatic nodule in the left buccal mucosa. The intraoral examination showed a 7-mm sessile and well-circumscribed nodule with firm consistency and smooth surface covered by slightly whitish mucosa. Excisional biopsy was carried out based on a clinical diagnosis of inflammatory fibrous hyperplasia. The histopathology demonstrated mature adipose tissue, spindle cells (CD34+), and many mast cells in a connective tissue stroma. The diagnosis of SCL was hence established. The patient is being followed up.

Prevalence of oral mucosal status in resident and non-resident nursing home in Isfahan city, Iran: a comparative cross-sectional study

Objective: The aim of this study was to evaluate the oral mucosal status of residents nursing home and non-resident in Isfahan, Iran and compare them with each other. Material and Methods: This was a cross-sectional study comparing 281 elderly in two groups: 141 resident and 140 non-residents nursing homes in Isfahan, Iran. The selection of nursing home and all of elderly was randomly. The nonresidents elderly were randomly selected from the public places adjacent to the nursing home. Persons were examining and the relevant information recorded in a checklists. Data were analyzed by SPSS version 24 using t-test, chi square, Mann- Whitney, Fisher exact test. (?=0/05). Results: The sample of the case was 281 people, including 135 males (48%) and 146 females (52%). Of all the subjects 153 patients (54.4%) had at least one oral lesion, 78 (55.3%) in resident nursing home and 75 (53.6%) in non-resident. There was no significant difference between two groups based on Chi-Square test (P>0/05). In this study, 25 different types of lesions were recorded, the most common lesion in all participants was epulis fissuratum (12.1%). Conclusion: The results showed that the prevalence of mucosal lesions is high in the elderly living in the centers and in the non-resident. Therefore, maintaining dentures is necessary to prevent and control lesions. KeywordsLesion; Mouth mucosa; Elderly; Nursing home; Cross-sectional study.

EPULIS FISSURATUM: COMPARISON OF CLINICAL IMPRESSION TO HISTOPATHOLOGIC DIAGNOSIS

Objective This study evaluated the percentage of cases correctly identified as epulis fissuratum based on the clinical impression and histopathologic diagnosis and evaluated the percentage of cases identified as a malignancy by the histopathologic diagnosis with a clinical impression of epulis fissuratum. Findings A search in the database systems at the biopsy services of University of Nebraska Medical Center College of Dentistry and Tufts University School of Dental Medicine for the clinical impression term epulis/epulis fissuratum from January 1, 2012 until July 1, 2017 was performed which identified 187 cases. The Fisher's exact test measured the similarity between dental practitioners’ clinical impression of epulis fissuratum and histopathologic findings. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the dental practitioners’ clinical impression about the malignancy of epulis fissuratum were calculated. P value Conclusion Based on the collected data, dental practitioners should remove and submit excised tissue for microscopic analysis to rule out malignancy in suspected cases of epulis fissuratum.

ORAL TISSUE CONDITION IN PROSTHODONTIC GERIATRIC PATIENTS

The world population is continuously getting older in developed and undeveloped countries. According to WHO over 20% of the population in Europe is over 65 years old. Geriatric population in North Macedonia is presented with 16% and with high prevalence of anodontia over 45, 1%, poor oral hygiene and urgent demand of prosthodontics treatment. Aging is a process with different and specific changes of all systems and organs, including the orophacial system. In this population, the number of remaining teeth is evidently reduced, their condition has changed, and soft and hard oral tissues are affected. It is very important to discover all the factors that lead to the development of leukoplakia and other precancerous lesions as early as possible. Precancerous lesions and oral carcinoma are more common in the elderly compared to the younger population. Almost 90% of oral cancers occur in patients older than 50 years. Early detection of oral mucosa diseases in elderly and potentially malignant disorders requires careful examination because of high malignant transformation frequency. The aim of the study was to determine the condition of oral soft tissues in geriatric prosthodontics patients, their general health and the impact of oral health on their quality of life. The value of the VELscope instrument as an adjunct to oral examination in geriatric prosthodontics patients was also evaluated. The study was performed in the University Dental Clinic Ss’ Panteleimon in Skopje, NM. Clinical protocol for 300 patients over 60 years old was questionnaire with risk factors, clinical intra and extraoral observation and VELscope mucosal tissue examination. Tissue changes were classified as inflammatory, traumatic, dysplastic and other. Abnormal tissue was associated with auto fluorescence loss and dark appearance in contrast to the surrounding healthy tissue. In 21% of patients abnormal premalignant lesions were detected. Leukoplakia was the most common premalignant disorder 42 (12, 6%), 16 (4, 8%) had lichen planus, 6 (1, 8%) cheilitis actinica and 5 patients (1, 5%) were diagnosed with squamous cell carcinoma. We found 118 inflammatory lesions (35, 4%) where 58 (17, 4%) were denture stomatitis, 18 (5, 4%) angular cheilitis, traumatic lesions were found in 38 patients (11, 4%) and 4 (1, 2%) were diagnosed with epulis fissuratum. In 54 patients (16, 2%) we diagnosed infectious changes from which aphtous ulcerations and candidiasis were most common. The VELscope fluorescence instrument can be used as a part of diagnostic process to detect abnormal tissue and oral lesions that might have been overlooked. A validation of the study was carried out and it was approved by the ethics committee of the Faculty for dentistry Ss Cyril and Methodius University Skopje on 18.12.2018. No. 02-38363.

Diode laser versus electrocautery for inflammatory fibrous hyperplasia treatment: a split-mouth clinical trial

Diode laser versus electrocautery for inflammatory fibrous hyperplasia treatment: a split-mouth clinical trial

Comparison of histochemical staining techniques for detecting mast cells in oral lesions

ABSTRACTMast cells are large cells with granular cytoplasm that participate in wound healing, angiogenesis and defense against pathogens. They also contribute to inflammation by initiating innate and acquired immunity. The granules of these cells exhibit characteristic staining properties. We investigated toluidine blue, astra blue, Alcian blue-pyronin Y and May-Grunwald Giemsa stains for mast cells in various oral lesions and assessed the efficacy of each for identifying mast cells. Sections were obtained from 10 each of diagnosed cases of inflammatory fibrous hyperplasia, periapical cyst, mild dysplasia, oral submucous fibrosis and oral squamous cell carcinoma and stained using the stains listed above. Mast cells were assessed for their presence, contrast of the mast cell in the connective tissue background and number. We found that May-Grunwald Giemsa stain was the best for identification of mast cells, although toluidine blue staining is less time-consuming. Overall we obtained better results using May-Grunwald Giemsa and toluidine blue for staining mast cells.

Profile evaluation of patients diagnosed with non-neoplastic proliferative lesions in a dentistry clinic

Non-neoplastic proliferative lesions (NNPLs) are alterations that affect oral mucosal tissues. The etiology of these lesions is associated with local irritant processes, principally inflammation, infections and mechanical irritants. NNPLs are classified into four groups: inflammatory fibrous hyperplasia, pyogenic granuloma, peripheral ossifying fibroma, and peripheral giant cell lesion. Aim: This cross-sectional, quantitative, retrospective, analytical, informative and educational study aimed to evaluate the profiles of patients who were diagnosed with any non-neoplastic proliferative lesion in the Unimontes Stomatology Clinic, Brazil. Methods: From January 2001 to June 2012, 1505 patients were counted who underwent anatomopathological examination, in addition to evaluations for other conditions. Results: Of these 1505 patients, 223 were diagnosed with some type of non-neoplastic proliferative lesion, and statistical analysis showed that 76% were female and 24% male and that 23.3% were between 41 and 50 years of age. Inflammatory fibrous hyperplasia was the most common NNPL (86.5%). Conclusion: Due to the high frequency of these lesions in the dental clinic, this type of survey has significant relevance for informing health professionals about these proliferative processes. This information is necessary, since the dentist is intimately involved in both the etiology, treatment and prevention of these lesions.

Lack of association between denture trauma and loss of heterozygosity confronts the proposed pathologic role of chronic mucosal trauma in oral carcinogenesis.

Chronic mucosal trauma is suggested as an additional etiologic risk factor for oral squamous cell carcinoma (OSCC), but there is a lack of experimental-molecular data. If chronic trauma of the oral mucosa is carcinogenic, it should be associated with early genetic alterations seen during typical progression of OSCC, like loss of heterozygosity (LOH). We investigated LOH in the key chromosomal arms 3p, 9p and 17p in inflammatory fibrous hyperplasia associated with removable dental prosthesis and also in normal oral mucosa, by using the polymorphic microsatellite markers D3S1300 at 3p14.2, D9S1748 at 9p21, D17S1289 at 17p12 and D17S974 at 17p13 and capillary electrophoresis. LOH was detected in 2/15 (13%) fibrous hyperplasia samples similarly to other reactive and inflammatory lesions. None of the normal mucosa samples presented LOH. Our experimental-molecular results do not support the hypothesis that trauma associated with dental prosthesis has an important role in oral carcinogenesis.

Comparative Evaluation of Diode Laser and Scalpel Surgery in the Treatment of Inflammatory Fibrous Hyperplasia: A Split-Mouth Study

Objective: This study aimed to compare the efficacy of diode laser surgery and the scalpel surgery in the removal of inflammatory fibrous hyperplasia (IFH). Background data: Diode laser systems are proposed as an alternative to scalpel surgery on surgeries involving oral soft tissues. Some of the advantages of the laser systems are ease of application, adequate coagulation, reduced postoperative pain, and decreased scarring. In addition, there are increasing data on the antibacterial effects of the diode lasers in dentistry; however, the direct bactericidal role of the diode laser in oral soft tissue procedures has not yet been investigated. Materials and methods: A total of 22 patients were enrolled in this study. One side of IFH was randomly assigned for excision with scalpel blade or with diode laser. Perioperative bleeding, postoperative pain, wound healing, and bacterial counts were evaluated for both methods. Results: The bleeding on the side treated by diode laser was found significantly lower (p < 0.05). A notable reduction in total bacterial counts was observed in the laser group after the first postoperative day. However, this trend did not reach statistical significance. No significant differences were recorded regarding subjective postoperative pain between the groups (p = 0.065). The healing of the postoperative wounds was significantly faster in the conventional group at each time point. Conclusions: Diode laser has offered some advantages over conventional method in the management of IFH. However, large-cohort comparative studies are required to provide additional data regarding the wound healing capacity of the diode laser.

Inflammatory fibrous hyperplasia: a rare case in a child

ABSTRACT This paper aims to describe an inflammatory fibrous hyperplasia case caused by chronic irritation due to poor dental positioning after trauma. An 11-year-old female patient was sent to a dental specialty center with the complaint of a soft tissue growth in the place of an unerupted maxillary central incisor, causing her behavioral changes becoming more timid. After anamnesis and clinical examination it was noted that tooth 11 was in a vestibular position, covered with a hyperplastic lesion. Surgical treatment was performed and the histopathological exam revealed inflammatory fibrous hyperplasia. Over the course of the follow-up appointments, it was possible to observe improvement on the mentioned tooth and the patient’s satisfaction. In face of the low prevalence of inflammatory fibrous hyperplasia, it is worth mentioning that the tooth positioning, outside its correct alignment in the arch, can cause repeated trauma to the mucosa, and then turning into etiological factor to inflammatory fibrous hyperplasia, affecting even children and adolescents. Thus, the dentistry must be alert to establish a diagnosis and clinical treatment, in addition to monitoring these cases.

Quantification of mast cells in reactive oral lesions – A clue to the morphologic diversity

OBJECTIVE: Inflammatory fibrous hyperplasia (IFH), pyogenic granuloma (PG), peripheral ossifying fibroma (POF), and peripheral giant cell granuloma (PGCG) are common oral soft-tissue reactive lesions that correspond to excessive connective tissue proliferation as a reaction to trauma or irritational factors local to the oral cavity. These lesions have specific differences in their histopathologic appearances and behavior in spite of having common etiologic factors. Mast cells (MCs) are immune-regulatory cells that have an important role to play in oral inflammation and have also been associated with tissue remodeling and fibrosis in various disorders. METHODOLOGY: MCs were stained with toluidine blue in cases of IFH (20), PG (20), PGCG (20), and POF (20) along with normal gingiva tissue as control (5) for quantification and comparison among them. RESULTS: The mast cell count was low in normal mucosa but a progressive increase was seen from PGCG to IFH to POF with maximum mast cells were evident in PG. There was a significant difference noted in the MC counts between the normal mucosa and the oral reactive lesions (P CONCLUSION: MCs emerged as significant players in the pathogenesis and histopathologic diversity of oral reactive lesions by their effects on fibroblasts and endothelial cells.

Inflammatory and reactive lesions of the orofacial region in an African tertiary health setting

Background: Chronic inflammatory and reactive lesions are tumor-like hyperplasia that are produced in association with chronic local irritation or trauma. These proliferations are painless pedunculated or sessile masses in different colors, from light pink to red. The surface appearance is variable from nonulcerated smooth to ulcerated growth, and they from a few millimeters to several centimeters in size. Common examples in the oral cavity include pyogenic granuloma (PG), epulis, traditional clinical name for gingival reactive proliferations, Irritation fibroma, epulis fissuratum, and giant cell granulomas which could either be of peripheral or central origin. Objective: To describe the pattern of inflammatory and reactive lesions of orofacial region. Materials and Methods: A retrospective study of patients attending the oral and maxillofacial clinic between January 2006 and December 2014 was undertaken. Results: One hundred and twelve patients, comprising 61 (54.5%) males and 51 (45.5%) females were seen over the period of study. Their age ranged from 1 to 80 years with a median age of 26.5 years. PG was the most frequently reported lesion accounting for 32 (28.6%). This was followed by nonspecific chronic inflammation (n = 23; 20.5%), epulis/peripheral giant cell granuloma (n = 13; 11.6%), granulation tissue (n = 10; 8.9%), and central giant cell granuloma, (n = 8; 7.1%). Conclusion: The results of the study show that inflammatory and reactive lesions are common in the study population.

Oral and maxillofacial lesions in older individuals and associated factors: A retrospective analysis of cases retrieved in two different services.

BackgroundStudies on the oral and maxillofacial lesions (OMLs) in older people usually assess data of laboratory services and data from oral medicine clinic have been poorly described. The aim of this study was to describe and to compare OMLs in older individuals considering two data sources, besides to assess associated factors with the three most frequent lesions.Material and MethodsA retrospective study was conducted with individuals aged 60 years or older. Data of individuals and lesions reported in both services were collected. Univariate analysis was used to test the association between the occurrence of the lesion and the independent variables. The level of significance was set at 5%.ResultsA total of 1,695 (37.3%) records were from the Oral Medicine clinic and 2,848 (62.7%) from the Laboratory service. Inflammatory/reactive lesion group was the most frequent in both services (40.4% in Oral Medicine Clinic and in 44.2% Laboratory). The second and third groups of lesions in the Oral Medicine clinic were infectious diseases (18.5%), and variations of normality (10.8%), while in the laboratorial service were the malignant neoplasms (17.6%) and potentially malignant disorders (13.3%). Differences between services regarding the frequency of lesion groups occurred (p<0.05), except for pigmented (p=0.054) and infectious (p=0.054) groups. Females (OR: 2.08; CI: 1.81–2.39) and individuals who wore a removable prosthesis (OR: 3.99; CI: 2.83–5.62) were also likely to have inflammatory fibrous hyperplasia. Old–old individuals (OR: 1.70; CI: 1.30–2.21), male (OR: 3.63; CI: 3.00–4.39), smoking (OR: 6.05; CI: 4.84–7.56) or alcohol use (OR: 3.95; CI: 3.12–5.01) were likely to have squamous cell carcinoma.ConclusionsThe results showed different frequencies of OMLs in older individuals according to the data sources and age group. The findings are important to direct public policies for this age group. Key words:Oral medicine, laboratory service, older adult, oral diagnosis, oral and maxillofacial pathology.

Analysis of risk factors for maxillary denture-related oral mucosal lesions: A cross-sectional study.

BackgroundTo evaluate the frequency of maxillary dentures-related lesions and the possible associated risk factors.Material and MethodsNinety-seven participants were selected, and a complete anamnesis, physical examination and tests of occlusion vertical dimension (OVD), retention and stability of the denture, biofilm quantification, cytopathology, sialometry, pH analysis and buffer capacity of the saliva were performed. Statistical analyses were performed with the Pearson’s chi-square, Mann-Whitney tests, and Pearson’s coefficient (p<0.05).ResultsIn 78% of the participants at least one denture-related lesion was found. Denture-associated stomatitis (63%), inflammatory fibrous hyperplasia (19%) and traumatic ulceration (11%) were the 3 most frequent lesions. The habit of night use of the denture was considered an independent risk factor for the development of oral lesions [OR=3.0 (95% CI 1.09-8.56); p<0.05]. Furthermore, the longest period of use of the same denture and biofilm also had statistically significant relation to oral lesions. The biofilm seems to be more related to the prevalence of oral lesions according to the multiple logistic regression [OR=1.3 (95% CI: 1.01-1.83) p<0.05]. The lack of a dentures’ cleaning solution and detrition of the prothesis were independent risk factors for denture-associated stomatitis. Male gender, loss of OVD and bad buffer capacity were risk factors for angular cheilitis. Fractures of the base and repair of broken dentures were risk factors for traumatic ulcers.ConclusionsThese results show a high frequency of denture-related lesions. Besides, participants hygiene habits and poor quality of the dentures were the main factors for the development of these lesions. Key words:Complete denture, oral health, oral hygiene, oral lesion, saliva.