Origami structure has become an important design source of metamaterials because of its extremely rich form and infinite design space. In order to improve the wave attenuation and impact mitigation ability of origami structure, a hybrid graded origami-inspired metamaterials with multiple resonators is proposed. The bandgap characteristics, transmission spectrum and impact resistance of the proposed metamaterials are analyzed in detail by numerical simulation. The results show that multiple local resonance mechanisms can open two new bandgaps compared to the single local resonance case, and the bandgap boundary is very sensitive to the dimension of resonance units. In particular, the resonance peaks of the origami metamaterials are substantially weakened due to the presence of dimensional gradients, which allows multiple bandgaps to merge into an ultra-wide bandgap (bandwidth up to 8.9 kHz), about five times than the original bandwidth. According to the time domain and frequency domain analysis results, it can be found that the amplitude of reaction force is significantly reduced in the bandgap range, and the ultra-wide frequency domain (2.9–10 kHz) with sustainable-low peak appears. Moreover, the asymmetry and graded design of unit-cell also affects the ability of dissipate and attenuate wave energy and delay the wave transmission time. In addition, the local-resonant origami metamaterials are fabricated by 3D printing technology, and the experimental results are in good agreement with the numerical simulation results. This study is expected to provide valuable ideas in crashworthiness design and impact wave protection of important equipments.