Abstract Cancer is a leading cause of morbidity and mortality among humans worldwide. Theoretical studies could provide biologists with complementary and valuable insight into the mechanisms that may control the development of solid tumors. Based on our studies on membrane formation kinetics, a novel growth model is established for solid tumor development, which is consistent with the experimental data. According to the concept of the proliferation-active cells in the tumor tissue, two parameters, the effective cell division cycle for mitosis and the effective infiltration distance relevant to the nutrient support, are introduced in the model. The two parameters introduced can be further applied when the drug effects were considered. We have reviewed over 200 literatures and selected more than 50 of them having experimental data from different cell lines for theoretical studies. The growth curves generated by our model are consistent with many experimental data including lung cancer, breast cancer, liver cancer, ovarian cancer and colon cancer. Thus, the model obtained is very important not only for cancer research but also for searching anti-cancer drug and therapies. In the figure below, we have displayed growth curves for colon carcinoma cell line. The dash lines are simulation curves of the model and the dots are the corresponding experimental data. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-131.