Study Objective This video describes the technique used to treat an isolated endometriotic nodule in the Ischial Spine Region emphasizing the anatomic aspect of this region. Design Isolated endometriotic nodule in the Ischial Spine Region diagnosed preop in one symptomatic patient by MRI. Laparoscopic resection with 6 months follow-up. Setting Through a laparoscopic approach using HD-3D microcamera which was inserted umbilical scar, with 3 auxiliary punctures of 5mm each in the inferior abdomen. Patients or Participants A 39-year-old patient was referred to the Center of Endometriosis. Her symptoms started about six years before the surgery. She reported pelvic pain, proctalgia, sciatica and perineal pain in the right side, paresthesia and burning on the inguinal region and the plantar face of the right foot, and chronic fatigue. Cyclical pain happened during menses, not relieved with non-steroidal anti-inflammatory drugs (NSAIDs). Preop CA-125 marker was 57.0 U/mL. Three years before surgery she reported a spontaneous abortion. Interventions A Laparoscopic resection of the endometriotic nodule in the ischial spine region. Measurements and Main Results The Surgical time: 230min. Removed nodule: 5cm. The patient is totally asymptomatic, without any pain or neurological deficits. After 6 months, she has started reproductive treatment. Conclusion This video demonstrates the infiltration of endometriosis in the complex region of the ischial spine, its excision and various aspects of anatomical dissection in vascular structures, muscles and nerve sparing. This video describes the technique used to treat an isolated endometriotic nodule in the Ischial Spine Region emphasizing the anatomic aspect of this region. Isolated endometriotic nodule in the Ischial Spine Region diagnosed preop in one symptomatic patient by MRI. Laparoscopic resection with 6 months follow-up. Through a laparoscopic approach using HD-3D microcamera which was inserted umbilical scar, with 3 auxiliary punctures of 5mm each in the inferior abdomen. A 39-year-old patient was referred to the Center of Endometriosis. Her symptoms started about six years before the surgery. She reported pelvic pain, proctalgia, sciatica and perineal pain in the right side, paresthesia and burning on the inguinal region and the plantar face of the right foot, and chronic fatigue. Cyclical pain happened during menses, not relieved with non-steroidal anti-inflammatory drugs (NSAIDs). Preop CA-125 marker was 57.0 U/mL. Three years before surgery she reported a spontaneous abortion. A Laparoscopic resection of the endometriotic nodule in the ischial spine region. The Surgical time: 230min. Removed nodule: 5cm. The patient is totally asymptomatic, without any pain or neurological deficits. After 6 months, she has started reproductive treatment. This video demonstrates the infiltration of endometriosis in the complex region of the ischial spine, its excision and various aspects of anatomical dissection in vascular structures, muscles and nerve sparing.