ABSTRACT Background: The target of this study is to identify the infectious microbial organisms that may encountered from during handling the cadaver and find the various methods of protection for the anatomists and the students in the dissection room. Materials and Methods: This study is a historical review of the previous studies between the years 2002 and 2022 taken from the database of Pubmed and Google Scholar by using the following keywords (infectious diseases, cadaver diseases, anatomists hazards, Cadavers; risk of disease transmission, anatomical dissection). Results: As a result of the literature review, it was concluded that every cadaver should be considered infectious material until proven otherwise. Conclusions: As a result of this article, it was concluded that the fixation of the cadaver does not prevent infectivity. And the only method to reduce morbidity and mortality resulted from handling cadavers is by following protective measures according to the guidelines. Both the proper preparation of the cadaver and the knowledge of the medical history of the cadaver play an important role in minimizing the risks associated with the procedure.