Infectious Disease Threats Research Articles

Stigmatization of Chinese and Asian-looking people during the COVID-19 pandemic in Germany

BackgroundThe outbreak and global spread of COVID-19 was accompanied by an increase in reports of stigmatization of Chinese and Asian-looking people. The behavioral immune system provides a framework for stigmatization in response to infectious disease threats. Specifically, stigmatization might increase with rising levels of infectious disease threat. The present study aimed to examine this hypothesis during the early phase of the COVID-19 pandemic.MethodsAs part of the “EUCLID” project (https://euclid.dbvis.de), a total of 5011 persons from Germany were surveyed via an online-questionnaire between February 2nd and April 3rd, 2020, covering the progression of the COVID-19 pandemic over three time periods which were defined by critical events.ResultsThere was no evidence for an increase in the stigmatization of Chinese and Asian-looking people across three topics, that is personal proximity, air travel, and medical measures upon arrival from China.ConclusionsThe present findings provide good news in that participants showed an adaptive response to the infectious disease threat rather than displaying increased stigmatization. Further research is necessary to specify the conditions that increase the risk of stigmatization in response to infectious disease threats.

Fostering East-West and North-South bidirectional collaborations

Communicable disease is a challenge that is widely recognized to be a consequence of globalization. Infectious disease threats such as SARS-CoV-2, Ebola, Zika, malaria, and yellow fever are easily transmissible through mass global processes such as migration and trade. Scholars are increasingly recognizing the value of international cooperation and transdisciplinary research to meet these infectious disease challenges and even to anticipate future challenges. However, international collaboration is not an easy process given the often-uneven relationships between the Global North and South due to histories of resource disparities. In the International Congress on Ecology and Evolution of Global Communicable Diseases held in Quito and Galapagos Islands, Ecuador in 2016, researchers developed a concrete framework for international, interdisciplinary collaboration toward tackling infectious disease challenges. We share the insights from the congress here in hopes of enabling other scientific researchers to engage in similar research partnerships and to forge collective progress toward a more efficient infectious disease research agenda. The following core competencies are addressed in this article: Medical knowledge, Interpersonal and communication skills, and Professionalism.

Levels of interpersonal trust across different types of environment: The micro-macro interplay between relational distance and human ecology.

Social and behavioral scientists have long investigated the relationship between interpersonal trust and features of the environment. However, it remains unclear how the microenvironment of relational distance (i.e., social proximity between 2 persons) interacts with the macroenvironment of human ecology (i.e., social and natural environments) to predict people's levels of trusting other persons. In this research, we tackled this puzzle using diverse methodologies (e.g., meta-analysis, experiment, and multilevel analysis) and large, cultural-group samples. Four studies found that, across many countries (e.g., 77 countries in Study 3) and regions within a country (e.g., 28 Chinese provinces in Study 4), members of these social units trusted close others (e.g., family members) more than distant others (e.g., strangers). However, this general effect of relational distance was stronger in societies embedded within more restrictive cultural, sociopolitical, and natural ecologies (e.g., a more collectivistic cultural logic, less developed socioeconomic and political institutions, and a stronger threat of infectious diseases, such as HCV infection). More importantly, people's attitudinal trust of distant others was higher in countries or regions with less restrictive ecocultural features, but such differences often disappeared in the context of trusting close others. Compared with other sociopolitical and natural features, the societal culture of collectivism often was a unique explanatory variable for the micro-macro interplay of current interest. These converging pieces of evidence provide a clear view of how levels of interpersonal trust vary as a function of relational distance and ecocultural environments simultaneously. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

A novel fusion-based deep learning model for sentiment analysis of COVID-19 tweets

Undoubtedly, coronavirus (COVID-19) has caused one of the biggest challenges of all times. The ongoing COVID-19 pandemic has caused more than 150 million infected cases and one million deaths globally as of May 5, 2021. Understanding the sentiment of people expressed in their social media comments can help in monitoring, controlling, and ultimately eradicating the disease. This is a sensitive matter as the threat of infectious disease significantly affects the way people think and behave in various ways. In this study, we proposed a novel method based on the fusion of four deep learning and one classical supervised machine learning model for sentiment analysis of coronavirus-related tweets from eight countries. Also, we analyzed coronavirus-related searches using Google Trends to better understand the change in the sentiment pattern at different times and places. Our findings reveal that the coronavirus attracted the attention of people from different countries at different times in varying intensities. Also, the sentiment in their tweets is correlated to the news and events that occurred in their countries including the number of newly infected cases, number of recoveries and deaths. Moreover, common sentiment patterns can be observed in various countries during the spread of the virus. We believe that different social media platforms have great impact on raising people’s awareness about the importance of this disease as well as promoting preventive measures among people in the community.

Sustainable Laboratory Capacity Building After the 2014 Ebola Outbreak in the Republic of Guinea.

Background: The 2014–2016 West Africa Ebola virus disease outbreak heavily impacted the Republics of Guinea, Sierra Leone, and Liberia. The outbreak uncovered the weaknesses of the public health systems, including inadequately trained and insufficient health personnel as well as limited and poorly equipped health infrastructures. These weaknesses represent significant threats to global health security. In the wake of the outbreak, affected countries made urgent requests for international engagement to help strengthening the public health systems.Methods: This work describes the successful multi-year implementation of a laboratory capacity building program in the Republic of Guinea. The program integrated biorisk and quality management systems training, infectious diseases diagnostic training, facility engineering and maintenance training, and mentorship to strengthen Guinea's bio-surveillance capacity.Results: The major outcome of these efforts was an established and local staff-operated public health laboratory that performs disease surveillance and reporting and diagnostic of priority diseases and pathogens of security concerns.Conclusions: This work has improved the Guinea country's capabilities to address country public health issues and preparedness to respond to future infectious disease threats.

The COVID University Challenge: A Hazard Analysis of Critical Control Points Assessment of the Return of Students to Higher Education Establishments.

The COVID‐19 pandemic has disrupted economies and societies throughout the world since early 2020. Education is especially affected, with schools and universities widely closed for long periods. People under 25 years have the lowest risk of severe disease but their activities can be key to persistent ongoing community transmission. A challenge arose for how to provide education, including university level, without the activities of students increasing wider community SARS‐CoV‐2 infections. We used a Hazard Analysis of Critical Control Points (HACCP) framework to assess the risks associated with university student activity and recommend how to mitigate these risks. This tool appealed because it relies on multiagency collaboration and interdisciplinary expertise and yet is low cost, allowing rapid generation of evidence‐based recommendations. We identified key critical control points associated with university student’ activities, lifestyle, and interaction patterns both on‐and‐off campus. Unacceptable contact thresholds and the most up‐to‐date guidance were used to identify levels of risk for potential SARS‐CoV‐2 transmission, as well as recommendations based on existing research and emerging evidence for strategies that can reduce the risks of transmission. Employing the preventative measures we suggest can reduce the risks of SARS‐CoV‐2 transmission among and from university students. Reduction of infectious disease transmission in this demographic will reduce overall community transmission, lower demands on health services and reduce risk of harm to clinically vulnerable individuals while allowing vital education activity to continue. HACCP assessment proved a flexible tool for risk analysis in a specific setting in response to an emerging infectious disease threat. Systematic approaches to assessing hazards and risk critical control points (#HACCP) enable robust strategies for protecting students and staff in HE settings during #COVID19 pandemic.

Why Social Distance Demands Social Justice: Systemic Racism, COVID-19, and Health Security in the United States.

Why Social Distance Demands Social Justice: Systemic Racism, COVID-19, and Health Security in the United States.

The Role of Noncommunicable Diseases in the Pursuit of Global Health Security.

Noncommunicable diseases and their risk factors are important for all aspects of outbreak preparedness and response, affecting a range of factors including host susceptibility, pathogen virulence, and health system capacity. This conceptual analysis has 2 objectives. First, we use the Haddon matrix paradigm to formulate a framework for assessing the relevance of noncommunicable diseases to health security efforts throughout all phases of the disaster life cycle: before, during, and after an event. Second, we build upon this framework to identify 6 technical action areas in global health security programs that are opportune integration points for global health security and noncommunicable disease objectives: surveillance, workforce development, laboratory systems, immunization, risk communication, and sustainable financing. We discuss approaches to integration with the goal of maximizing the reach of global health security where infectious disease threats and chronic disease burdens overlap.

Tuberculosis and Covid-19 Co-Infection – Clinical Characteristics

Abstract The threat of contagious infectious diseases is constantly evolving as demographic explosion, travel globalization and changes in human lifestyle increase the risk of speeding pathogens, leading to accelerate changes in disease landscape.(1) Tuberculosis and Covid-19 are both infectious diseases that attack primarily the lungs. Both diseases have similar symptoms such as cough, fever and difficulty breathing. Tuberculosis has a longer incubation period with a slower reset of disease. Experience on Covid-19 infection in TB patient remains limited. 8 studies reported a total of 80 patients with this co-infection. These patients were reported from 9 different countries, with Italy reporting the largest number of cases.(2) The aim of this study is to evaluate the characteristic of TB and Covid-19 co-infection in 10 patients who were admitted in the Pulmonology Hospital of Sibiu between 01.05.2020-30.04.2021. All of these patients were with nosocomial infection Covid-19 and were previously diagnosed with TB.

The COVID-19 pandemic, authoritarianism, and rejection of sexual dissenters in Poland.

In Poland, gender hierarchy restricting women’s sexuality and hetero-normativity are rooted in traditional ‘family values’ supported by the teachings of the Polish Catholic Church and attached to Polish national identity. Dissenters to traditional norms regulating gender and sexual relations are rejected as threat to social order and national unity. Latent growth curve modeling performed on data from a three-wave longitudinal study indicated linear, inter-related increases in authoritarianism, a desire for national cohesion and rejection of sexual dissenters in the nationally representative sample of participants (N = 889) as the COVID-19 pandemic unfolded in Poland. Data were collected before and during the outbreak of the pandemic allowing us to link the changes in social attitudes to this naturally occurring threat. Cross-lagged panel analysis indicated that authoritarianism predicted desire for national cohesion, which resulted in rejection of dissenters. These results are in line with theoretical models of authoritarianism as a response to threat. They are also in line with findings linking death anxiety and the threat of infectious disease to increases in authoritarianism, traditional worldview defense, in-group cohesion and sexual restrictiveness.

COVID-19’s impact on tourism: will compensatory travel intention appear?

ABSTRACT The coronavirus disease (COVID-19) has had a major impact on global tourism. We adopted social media data to quantify the change in Chinese consumers’ attitudes toward traveling during the pandemic, as no study has explored whether there is compensatory travel intention under the threat of infectious diseases. Using natural language processing technology and geographic information system technology, our analysis shows that Chinese consumers’ interest in tourism increased during the pandemic. Our results show that travel attitudes can be positively affected by compensatory consumption when travel is restricted by infectious diseases and has implications for tourism scholars, marketing managers, and stakeholders.

National Legal Paradigms for Public Health Emergency Responses

The COVID-19 pandemic has exposed significant weaknesses of the U.S. federalist system in controlling major infectious disease threats. At the root of American failures to adequately respond is a battle over public health primacy in emergency preparedness and response. Which level of government—federal or state—should actually “call the shots” to quell national emergencies? Constitutional principles of cooperative federalism suggest both levels of government are responsible. Yet, real-time applications of these principles, coupled with dubious national leadership, contributed to horrific public health outcomes across America. No one seeks a “repeat performance” of U.S. COVID-19 response efforts to forthcoming major health threats. Avoiding it entails substantial changes. Expansive interpretations and executions of core federal emergency powers illuminate new paradigms for Twenty-first century public health crisis planning, preparedness, and response where states remain key players, but the feds are primary play-callers.

Pathogenicity and transmissibility of a novel respirovirus isolated from a Malayan pangolin.

The identification of SARS-CoV-2-like viruses in Malayan pangolins (Manis javanica) has focused attention on these endangered animals and the viruses they carry. We successfully isolated a novel respirovirus from the lungs of a dead Malayan pangolin. Similar to murine respirovirus, the full-length genome of this novel virus was 15 384 nucleotides comprising six genes in the order 3'-(leader)-NP-P-M-F-HN-l-(trailer)-5'. Phylogenetic analysis revealed that this virus belongs to the genus Respirovirus and is most closely related to murine respirovirus. Notably, animal infection experiments indicated that the pangolin virus is highly pathogenic and transmissible in mice, with inoculated mice having variable clinical symptoms and a fatality rate of 70.37 %. The virus was found to replicate in most tissues with the exception of muscle and heart. Contact transmission of the virus was 100 % efficient, although the mice in the contact group displayed milder symptoms, with the virus mainly being detected in the trachea and lungs. The isolation of a novel respirovirus from the Malayan pangolin provides new insight into the evolution and distribution of this important group of viruses and again demonstrates the potential infectious disease threats faced by endangered pangolins.

World Health Organization High Priority Pathogens: Ophthalmic Disease Findings and Vision Health Perspectives.

Recent Ebola epidemics, the ongoing COVID-19 pandemic, and emerging infectious disease threats have highlighted the importance of global infectious diseases and responses to public health emergencies. Ophthalmologists are essential health care workers who provide urgent and emergent vision care services during outbreaks and address the ocular consequences of epidemic and pandemic infectious diseases. In 2017, the World Health Organization (WHO) identified high priority pathogens likely to cause a future epidemic with the goal of guiding research and development to improve diagnostic tests, vaccines, and medicines. These measures were necessary to better inform and respond to public health emergencies. Given the ocular complications associated with emerging infectious diseases, there is a need to recognize the ophthalmic sequelae for future vision health preparedness for potential future outbreaks. The WHO High Priority pathogens list provides a roadmap for ophthalmologists and subspecialty providers that will guide strategic areas of research for clinical care and preparedness for future pandemic threats. This review summarizes these key viral pathogens, summarizes major systemic disease findings, and delineates relevant ocular complications of the WHO High Priority pathogens list, including Crimean-Congo hemorrhagic fever, Filovirus diseases (Ebola virus disease and Marburg hemorrhagic fever), human Coronaviruses, Lassa Fever, Nipah virus infection, Zika, and Rift Valley fever.

SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca2+

Coronaviruses are a major infectious disease threat, and include the zoonotic-origin human pathogens SARS-CoV-2, SARS-CoV, and MERS-CoV (SARS-2, SARS-1, and MERS). Entry of coronaviruses into host cells is mediated by the spike (S) protein. In our previous ESR studies, the local membrane ordering effect of the fusion peptide (FP) of various viral glycoproteins including the S of SARS-1 and MERS has been consistently observed. We previously determined that the sequence immediately downstream from the S2′ cleavage site is the bona fide SARS-1 FP. In this study, we used sequence alignment to identify the SARS-2 FP, and studied its membrane ordering effect. Although there are only three residue differences, SARS-2 FP induces even greater membrane ordering than SARS-1 FP, possibly due to its greater hydrophobicity. This may be a reason that SARS-2 is better able to infect host cells. In addition, the membrane binding enthalpy for SARS-2 is greater. Both the membrane ordering of SARS-2 and SARS-1 FPs are dependent on Ca2+, but that of SARS-2 shows a greater response to the presence of Ca2+. Both FPs bind two Ca2+ ions as does SARS-1 FP, but the two Ca2+ binding sites of SARS-2 exhibit greater cooperativity. This Ca2+ dependence by the SARS-2 FP is very ion-specific. These results show that Ca2+ is an important regulator that interacts with the SARS-2 FP and thus plays a significant role in SARS-2 viral entry. This could lead to therapeutic solutions that either target the FP-calcium interaction or block the Ca2+ channel.

How College Students Assess the Threat of Infectious Diseases: Implications for University Leaders and Health Communicators

Higher education institutions and their students face a wide range of infectious disease threats (IDTs). However, there is a lack of theory-driven research on how to provide communication for multiple IDTs to motivate protective action taking. To close this gap, this study focuses on college students and two IDT types: respiratory and sexually transmitted infections. We tested an IDT appraisal model with data from an online survey conducted at two U.S. universities with 842 students. Findings indicate that IDT type led to different patterns of threat appraisal and protective action taking intentions. More specifically, participants perceived sexually transmitted threats as significantly more predictable and more controllable than respiratory threats. Participants also had higher intention to take protective action in response to respiratory threats than sexually-transmitted threats. We also found that external attribution-dependent (EAD) emotions (i.e., anger, sadness, surprise, and confusion) and an internal-attribution-dependent (IAD) emotion (i.e., hope) were sequential mediators in the relationship between IDT appraisal and protective action taking intentions for both infectious disease types. Implications for IDT communication research and practice are discussed.

Antimicrobial resistance research in a post-pandemic world: Insights on antimicrobial resistance research in the COVID-19 pandemic

Antimicrobial resistance must be recognised as a global societal priority - even in the face of the worldwide challenge of the COVID-19 pandemic. COVID-19 has illustrated the vulnerability of our healthcare systems in co-managing multiple infectious disease threats as resources for monitoring and detecting, and conducting research on antimicrobial resistance have been compromised during the pandemic. The increased awareness of the importance of infectious diseases, clinical microbiology and infection control and lessons learnt during the COVID-19 pandemic should be exploited to ensure that emergence of future infectious disease threats, including those related to AMR, are minimised. Harnessing the public understanding of the relevance of infectious diseases towards the long-term pandemic of AMR could have major implications for promoting good practices about the control of AMR transmission.

Development of an interactive, agent-based local stochastic model of COVID-19 transmission and evaluation of mitigation strategies illustrated for the state of Massachusetts, USA.

Since its discovery in the Hubei province of China, the global spread of the novel coronavirus SARS-CoV-2 has resulted in millions of COVID-19 cases and hundreds of thousands of deaths. The spread throughout Asia, Europe, and the Americas has presented one of the greatest infectious disease threats in recent history and has tested the capacity of global health infrastructures. Since no effective vaccine is available, isolation techniques to prevent infection such as home quarantine and social distancing while in public have remained the cornerstone of public health interventions. While government and health officials were charged with implementing stay-at-home strategies, many of which had little guidance as to the consequences of how quickly to begin them. Moreover, as the local epidemic curves have been flattened, the same officials must wrestle with when to ease or cease such restrictions as to not impose economic turmoil. To evaluate the effects of quarantine strategies during the initial epidemic, an agent based modeling framework was created to take into account local spread based on geographic and population data with a corresponding interactive desktop and web-based application. Using the state of Massachusetts in the United States of America, we have illustrated the consequences of implementing quarantines at different time points after the initial seeding of the state with COVID-19 cases. Furthermore, we suggest that this application can be adapted to other states, small countries, or regions within a country to provide decision makers with critical information necessary to best protect human health.

Study of New Normal Business Continuity to Improve Resilience Against Uncertain Threat

The Coronavirus Disease (COVID-19) pandemic has significantly influenced a lot of organizations. Business Continuity Planning (BCP) should be developed within each organization; however, it is not effective and perplexes organizations. The COVID-19 pandemic will remain prevalent for a few years, and there is a possible future threat of other infectious diseases. Therefore, it is important to learn from this pandemic and apply this knowledge to future BCP. In this study, issues with COVID-19 BCP are clarified by analyzing an online discussion among willing participants. The following suggestions resulted from the analysis: 1. It is difficult to obtain reliable information when it is necessary. 2. Decisions must be made, not knowing whether governmental measures are appropriate or not. 3. Fear results in bias. 4. Responses may delay if one is too dependent upon the assistance and information from government and/or other sources. Based on these results, BCP during the pandemic is suggested to encourage resilience during the uncertain threat expected in the future.

The Impact of Preparedness in Defying COVID-19 Pandemic Expectations in the Lower Mekong Region: A Case Study.

ABSTRACTDire COVID-19 expectations in the Lower Mekong Region (LMR) can be understood as Cambodia, the Lao PDR, Myanmar, Thailand, and Vietnam have stared down a succession of emerging infectious disease (EID) threats from neighboring China. Predictions that the LMR would be overwhelmed by a coming COVID-19 tsunami were felt well before the spread of the COVID-19 pandemic had been declared. And yet, the LMR, excepting Myanmar, has proved surprisingly resilient in keeping COVID-19 contained to mostly sporadic cases. Cumulative case rates (per one million population) for the LMR, including or excluding Myanmar, from January 1 to October 31 2020, are 1,184 and 237, respectively. More telling are the cumulative rates of COVID-19–attributable deaths for the same period of time, 28 per million with and six without Myanmar. Graphics demonstrate a flattening of pandemic curves in the LMR, minus Myanmar, after managing temporally and spatially isolated spikes in case counts, with negligible follow-on community spread. The comparable success of the LMR in averting pandemic disaster can likely be attributed to years of preparedness investments, triggered by avian influenza A (H5N1). Capacity building initiatives applied to COVID-19 containment included virological (influenza-driven) surveillance, laboratory diagnostics, field epidemiology training, and vaccine preparation. The notable achievement of the LMR in averting COVID-19 disaster through to October 31, 2020 can likely be credited to these preparedness measures.