Leaf spot diseases caused by pathogenic fungi, including Septoria albopunctata and Gloeosporium minus may cause premature defoliation of blueberry bushes that results in reduced flower bud set in the fall of the year, and thus reduced yield the following season. The objective of this experiment was to evaluate fungicides for control of disease and to establish whether yield responses occurred the following year. Experiments were conducted during 1998-99 on a 10-yr-old planting of the cultivar Croatan at the North Carolina State University Horticultural Crops Research Station in Castle Hayne, NC. Fungicides were applied as foliar sprays in a randomized complete block design with four replications. A CO2 powered backpack sprayer delivering the equivalent of 50 gallons per acre (468 l/ha) at approximately 40 psi (2.81 kg/cm2), with a single hollow-cone nozzle was used. Treatments were applied from early bloom through small green berry stage on 27 Mar, 8 Apr, 22 Apr and 5 May. Bushes were evaluated by rating percent leaves infected and percent leaf area infected on 7 Aug 98, and percent defoliation on 29 Sep 98. Fruiting twigs and number of flower buds per twig on treated bushes were counted on 28 Jan 99. Berries were harvested 1 Jun 99 to determine yield in the year following leafspot control measures. Of the fungicides tested, only Indar (fenbuconazole) significantly reduced defoliation and increased yields the following year. Nearly 13 months after the last spray was applied, Indar-treated bushes averaged 16.2 dry pints/bush (8.92 liters) vs 11 dry pints/bush (6.06 liters) for unsprayed bushes. Indar increased bud number per bush/number of berries per bush, as well as average number of buds per twig/number of berries per twig. The use of a surfactant did not significantly improve the performance of Indar. As expected, individual berry size was slightly larger on bushes with reduced yields.