In the present study conducted on effect of Ivermectin drug on infected hens with lice. the data showed that, this drug have a poisonous effected on lice parasite during the first three days of treatment. At the same time have no toxisicity on treated hens.. Also the ivermectin is not negative effect on the eggs production of the infected and treated hens. There are only 8 eggs for 25 hens injected the drug ,but the rate increased to 19 eggs, and the size of the hens become larger after one week from injection the drug.The study was show a positive effect for drug in parasite and its eggs , and the blood parameters were returned to normal values in infected hensafter treatment with drug. Additionally , were found the each of hemoglobin values for infected hens befor treatment were 10-14 mg/dl ,sugar 200-250 mg/100ml and alkaline phosphates enzyme 1.5-3.5 K.A.S/100ml ,but after treatment the values above were different where the hemoglobin values 10-12 mg/dl , sugar 185-240 mg/100ml and levels of alkaline phosphates enzyme was 1.3-4.5 K.A.S/100ml.