Macrosomia Research Articles

Real Time Monitoring of Vitals of a Baby Using IoT- Enabled Smart Baby Incubator

Recently born babies are exceptionally touchy to unpleasant situations. The tidy and temperature issues here can be life debilitating. Due to these issues, a child hatchery is made that can give the same temperature and natural conditions as a mother's womb does, as well as it screens the baby's restorative conditions such as heart beat, skin temperature, inside temperature, spo2 level, baby weight etc. Being physically show with the patients has gotten to be a gigantic issue for specialists. In such cases, actualizing IoT with healing center hardware such as a Child Hatchery has gotten to be one of the fundamental objectives for us. Giving an app that can track the baby's condition remotely will demonstrate to be exceptionally productive. Our fundamental objective is to make a savvy infant hatchery that can distinguish baby's condition and in case anything goes off-base, the framework can trip itself so that the conditions can return to a typical state. We will coordinate it with IoT and a versatile app so that specialists can check the baby's condition remotely. It can be simple to think of a hatchery as fair a bed for a sick infant, but it's so much more than a put for resting. An hatchery is outlined with such methods and care that it can give a safe and sound climate for a infant child to rest until it’s imperative organs are still in a advancement arrange. When we compare our incubator to a basic healing center bed, and hatchery will give a totally controlled environment as well as the required sum of oxygen levels, idealize light presentation and mugginess matches with the mother's womb. In expansion to climate control, a hatchery offers security from other hurtful components that can harm a child such as allergens, boisterous commotions, microscopic organisms and infections, etc. An incubator's capacity to control stickiness too permits it to secure a baby's skin from losing as well much water and getting to be delicate or cracking. An hatchery can incorporate hardware to track a run of things counting a baby's temperature and heart rate. This monitoring permits medical caretakers and specialists to always track a baby's well being status.

The Effect of Baby Massage on Body Weight and Sleep Quality of Babies Aged 3-6 Months

The Effect of Baby Massage on Body Weight and Sleep Quality of Babies Aged 3-6 Months

TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study.

Gestational diabetes mellitus (GDM) is one of the most frequent predictors of obstetric outcome among Romanian pregnant women. Thus, we aimed to investigate the role of rs7903146 (C/T) TCF7L2 gene polymorphism in the presence of GDM and to evaluate the influence on maternal-fetal outcomes in a cohort of pregnant women from Northern Transylvania. Our prospective case-control study was performed in a tertiary maternity center on 61 patients diagnosed with GDM and 55 normal pregnant patients. The patients were genotyped for rs7903146 (C/T) polymorphism of the TCF7L2 gene using the PCR-RFLP method between 24 and 28 weeks of gestation. The minor T allele was associated with a high risk of developing GDM (OR 1.71 [95% CI 0.82-3.59]) if both heterozygote and homozygote types were considered. Also, a higher risk of developing GDM was observed in homozygous carriers (OR 3.26 [95% CI 1.10-9.68]). Women with the TT genotype were more likely to require insulin therapy during pregnancy than other genotypes with a 5.67-fold increased risk ([1.61-19.97], p = 0.015). TT homozygote type was significantly associated with fetal macrosomia for birth weights greater than the 95th percentile (p = 0.034). The homozygous TT genotype is associated with an increased risk of developing GDM. Also, rs7903146 (C/T) TCF7L2 variant is accompanied by a high probability of developing insulin-dependent gestational diabetes mellitus (ID-GDM). The presence of at least one minor T allele was associated with a higher risk of fetal macrosomia.

Comparison of Vegetables and Nuts in Increasing Milk Production in Breastfeeding Moms and Increasing Baby Weight

Objective: To determine the effect of sweet potato leaves on the smooth production of breast milk and increase in baby weight at the Klari Health Center UPTD in 2023. Method: Quasy Experiment with one group pretest-posttest design. The sample was 56 breastfeeding mothers 4 days after giving birth whose breast milk production was not smooth using a convenience sampling technique. Bivariate analysis uses paired simple t test. Results: The results of univariate research on the smoothness of breast milk production before consuming sweet potato leaves (pretest) were mostly substandard at 57.1% with an average of 5.16. After consuming sweet potato leaves (posttest), most of them were 69.6% smooth with an average smooth breast milk production of 6.63. Most babies' weight before consuming sweet potato leaves (pretest) did not increase by 73.2%, afterward most of it increased by 60.7%. The results of bivariate research on the smoothness of breast milk production obtained a p value = 0.000 and an increase in the baby's weight obtained a p value = 0.000. Theoritical framework: Non-smooth breast milk production can hinder the process of exclusive breastfeeding due to the mother's desire to take steps to stop breastfeeding and replace it with formula milk. There are many ways that can be done to facilitate breast milk, including through non-pharmacological measures such as consuming sweet potato leaves which can be consumed freshly or made into clear vegetables. Conclusions and Suggestions: There is an effect of sweet potato leaves on the smooth production of breast milk and increasing the baby's weight. Nursing mothers are expected to consume sweet potato leaves regularly during breastfeeding in order to increase breast milk production so that breast milk production runs smoothly and the mother's baby gets exclusive breast milk.

Confluence of newborn's sex and their mother's characteristics resulting in fetal macrosomia among Indian neonates

BackgroundA newborn's birth weight ≥4000 g is defined as fetal macrosomia, which is recognized as a reproductive and serious child health concern. ObjectivesOur study aims to reveal existence of any connection between maternal factors and newborn sex in giving birth to newborn ≥4000 g in an Indian context. MethodsData were drawn from the fifth round of National Family Health Survey (NFHS-5). A cross-sectional observational study was carried out with a total of 152,827 children born to women in reproductive age group (15–49) who had most recent live birth in the five years preceding the survey. Descriptive analyses, cross-tabulation, test of association and multivariate logistic regression analyses were performed. ResultsIn India, the prevalence of macrosomia was found in 3.8% of the total study participants. Considering newborn characteristics, fetal macrosomia was more prevalent among male neonates than female (AOR: 0.730; 95% CI: 0.687–0.775). Regarding maternal characteristics, overweight (AOR: 1.468; 95% CI: 2.042–2.559) and obese (AOR: 2.764; 95% CI: 2.394–3.192) motherswith gestational diabetes (AOR: 1.731, 95% CI: 1.385–2.164) and hypertension (AOR: 1.288, 95% CI: 1.116–1.488) were more likely to giving birth of macrosomic babies. Multiparous mothers (AOR: 1.207, 95% CI: 1.128–1.293) and women who did not undergo proper antenatal care (ANC) follow up had also greater risk of developing fetal macrosomia. Muslim women (AOR: 1.223, 95% CI: 1.119–1.338), and women belonging to a tribe (AOR: 1.476, 95% CI: 0.922–2.361) were significantly associated with the risk of having newborn ≥4000 g. ConclusionEmphasis should be given on counseling for mothers for desired weight management before and during pregnancy, gestational diabetes and hypertension screening, physical activity during pregnancy, adequate ANC follow up and balanced dietary intake among pregnant women.

Association of Parity with the Risks of Gestational Diabetes and Macrosomia: A Retrospective Cohort Study in Nanjing, China.

After implementing the two-child policy, more Chinese women who had a previous delivery had their second child. Nevertheless, the impacts of parity on Gestational Diabetes (GDM) and macrosomia have not been fully confirmed. Therefore, we aimed to analyse the characteristics of pregnancy by parity and evaluate the association of parity with risks of GDM/macrosomia in a Chinese population. A total of 193,410 pregnant women (including 148,293 primiparae and 45,117 multiparae) with complete information were included. Univariate and multivariate logistic regression analyses were used to examine the association between parity and risks of GDM/macrosomia. With the gradual implementation of the two-child policy, the proportion of multiparae increased rapidly and then decreased slightly. Multiparae were more likely to be older and have higher intrapartum BMI, as compared to primiparae (P < 0.001). Univariate regression analyses suggested that parity could increase the risks of GDM and macrosomia; while after adjustment, the association between parity and GDM risk disappeared, and the effects of parity on macrosomia risk and birth weight of babies were also weakened. Further, stratified analysis showed that parity only increased the risk of GDM in women over 30 years, and the effects of parity on macrosomia risk and birth weight were more pronounced among women over 30 years compared to women under 30 years. Parity was not associated with GDM risk, but mildly associated with macrosomia risk. Particular attention should be paid to multiparae with advanced age to reduce the risks of GDM and macrosomia.

Pengaruh Pemberian Ekstrak Daun Kelor Terhadap Peningkatan Berat Badan Bayi Usia 6 -12 Bulan

Complementary food is additional food for babies which must contain the energy and substances needed by the body. Decreased immune system has a negative impact on the health of children under five. One way is to use natural ingredients such as Moringa leaves which are processed into food that is liked by babies. The aim of this research is to determine the effect of giving Moringa leaf extract on the weight gain of babies aged 6 - 12 months in the Samata Community Health Center Working Area in 2022. The research was conducted in 2022. May 2021- December 2022. The research design used is quantitative research with a One Group Pretest and Posttest quasi-experimental design. The population is 32 babies aged 6-12 years from October - December 2021. The sampling technique is Total Sampling. Data analysis was carried out univariate and bivariate using the Paired Sample T-Test. The research results obtained from the Normality test showed a significance value of &gt; 0.05, so the data was normally distributed, the univariate test showed that the distribution of the average increase in baby weight was 12.85 kg to 13.53 kg before and after being given Moringa leaf extract in complementary foods for breast milk. , and there was a significant influence between the baby's appetite and weight before and after being given Moringa leaf extract with a P-Value of 0.000 &lt; 0.05. Based on the research results, it was concluded that there was a significant effect between Moringa leaf extract and increased body weight before and after administration. So it is recommended for the Samata Community Health Center to provide innovative additional food for babies to improve the nutritional status of babies at the Samata Community Health Center.

Effect Of Baby Massage On The Weight Of Babies Aged 3-6 Months In The TPMB Of The Kelapa Gading Region, North Jakarta

Regular monitoring of children's growth and development must start from an early age as an effort to obtain quality human resources. Baby massage can reduce morbidity rates, baby massage is useful for increasing baby weight, increasing growth, increasing endurance, increasing breast milk production, improving blood circulation and breathing and improving sleep quality. Baby massage can also optimize baby growth and development. The aim of the research was to determine the effect of baby massage on the weight of babies aged 3-6 months in the TPMB Kelapa Gading area, North Jakarta. This research uses a Quasi Experimental method with a pretest and posttest research design. The sample in this study was 20 babies aged 3-6 months. The sampling technique uses purposive sampling. Data analysis used General Linear Model (GLM) Repeated Measures design with Pretest-Posttest Design. The type of contrast used is difference contrast. During the first week of massage, the average baby's weight increased by 102.5 grams. And by the fourth week, the average baby's weight increased to 297 grams. Overall, the average increase in baby weight was 780.5 grams, this proves that baby massage has proven effective in increasing baby weight. It was found that there was a difference in the average weight of babies before and after baby massage of 780.5 grams at TPMB in the Ranting Kelapa Gading area, Jakarta.

Effect of Maternal Obesity on Pregnancy Outcomes and Metabolic Consequences

Background: Maternal obesity has emerged as a critical public health issue with profound implications for both maternal and neonatal health. The increasing prevalence of obesity among women of reproductive age underscores the urgency of examining its impact on pregnancy outcomes and the metabolic health of offspring. Previous studies have identified associations between maternal obesity and adverse pregnancy outcomes, including gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), and cesarean delivery, as well as long-term metabolic disturbances in offspring. Objective: This study aimed to investigate the effects of maternal obesity on pregnancy outcomes and to elucidate the potential metabolic consequences for offspring, contributing to the understanding of intergenerational transmission of metabolic risk. Methods: Conducted at the Gyne B Unit of Hayatabad Medical Complex, Peshawar, this retrospective cohort study included 6,910 obstetric admissions from January to December of the previous year. Pregnant women aged 18-45 years with singleton pregnancies were included, excluding those with pre-existing medical conditions. BMI was calculated from self-reported pre-pregnancy weight and height. Outcomes analyzed included GDM, HDP, mode of delivery, macrosomia, neonatal hypoglycemia, stillbirth, and neonatal mortality. Data analysis utilized SPSS version 25, employing descriptive statistics, chi-square tests, t-tests or Mann-Whitney U tests, and multivariable logistic regression models. Results: Among the participants, 55.7% were of normal weight, 20.6% overweight, and 18.4% obese. Obese pregnant women demonstrated significantly higher rates of GDM (8.6% vs. 23.7%, p=0.001), HDP (18.3% vs. 6.4%, p=0.011), and cesarean delivery (55.7% vs. 30.1%, p=0.003) compared to their normal-weight counterparts. Offspring of obese mothers had a higher incidence of fetal macrosomia (10.2% vs. 5.4%, p=0.001) and neonatal hypoglycemia (10.4% vs. 6%, p&lt;0.001). Conclusion: The study confirms the significant association between maternal obesity and adverse pregnancy outcomes, including increased risks of GDM, HDP, and cesarean delivery. Furthermore, offspring of obese mothers are at an elevated risk of metabolic disturbances, indicating the necessity of addressing maternal obesity to improve health outcomes for both mothers and their children.

Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia.

Metabolic bone disease of premature infants is a rare complication characterized by a lower mineral content in bone tissue. To establish the incidence of metabolic bone disease in premature infants and to determine associated risk factors. We conducted a descriptive prospective cohort study for one year in all newborns under 32 gestational weeks, or 1,500 g, at the Hospital Universitario de Santander to determine the incidence of metabolic bone disease. We collected demographic data and prenatal histories of the selected patients, and later, we measured serum alkaline phosphatase and serum phosphorus at the third week of birth, having as reference values for diagnosis less than 5.6 mg/dl for the first one and more than 500 UI/L for the second one. We applied statistical tools for data analysis, such as average proportions, dispersion, distribution and association measures, and binomial regression. From a total of 58 patients, 7 had a diagnosis of metabolic bone disease, with an incidence of 12%. The weight was reported as an independent variable for the development of the disease, being significant in children under 1,160 g, as well as prolonged parenteral nutrition for more than 24 days. When performing the multivariate analysis, low weight and short time of parenteral nutrition appeared as risk factors; in the same way, maternal age below 22 years is associated with a higher relative risk, even more than a newborn weight inferior to 1,160 g. Establishing an early intervention in patients with metabolic bone disease enhancing risk factors, such as low weight and prolonged parenteral nutrition, is critical to prevent severe complications.

Fetal Outcome among Women with Postdate Pregnancy

OBJECTIVE: The study aimed to determine the mode of delivery and fetal outcome among women with postdated pregnancies. METHODOLOGY: This cross-sectional study was conducted from July to December 2020 in the Department of Gynecology, Hayatabad Medical Complex, Peshawar. A total of 287 women with postdated pregnancies (beyond 41 weeks) were selected through a convenient sampling technique for the study and followed to detect expected fetal outcomes. All women of age 20-45 with no signs of labor onset and cepahlic presentation of singleton pregnancy were included, while women with retained placenta detected by ultrasound, women with a medical disorder like coagulopathies (Haemophilia, Von Willebrand disease, Thrombocytopenia, DIC, Protein S deficiency, Protein C deficiency) detected by the specific investigation were excluded from the study. Data was analyzed using SPSS version 20. RESULTS: The mean age of the sample was 30.5 years, with a standard deviation of 6.1 years. The mean parity of the sample was 2.1±1.5. The mean BMI of the sample was 26.1±3.8kg/m2. On follow-up, fetal distress in 16%, macrosomia in 18.5%, birth asphyxia in 18.1%, meconium aspiration in 8.4% and NICU admission in 9.1%. None of the neonates died in this study. CONCLUSION: Postdated pregnancy carries a high risk of fetal distress, macrosomia and birth asphyxia. We recommend more large-scale surveys as well as trials to determine the efficacy of induction before pregnancy enters the postdate period and reduce the morbidity and mortality due to postdate pregnancies. KEYWORDS: Postdate Pregnancy, Meconium Aspiration, Birth Asphyxia, Fetal Distress, Intrauterine Growth Restriction, Macrosomia

Infant Weight Faltering and Feeding Patterns at 6 Weeks Post Delivery in a Rural East African Community: Comparing Incremental Versus Static Weight Assessments

Infant Weight Faltering and Feeding Patterns at 6 Weeks Post Delivery in a Rural East African Community: Comparing Incremental Versus Static Weight Assessments

Association of Vitamin D Intake in Pregnant Women and Birth Weight

Background: Insufficient maternal consumption of vitamin D can have adverse effects on fetal development and increase the likelihood of low birth weight. This research aimed to establish the correlation between the quantity of vitamin D consumed by expectant mothers and the weight of newborns. Methods: This study utilized an analytical observational design with a cross-sectional approach, collecting data from August to November 2022. Information on Vitamin D intake and birthweight was obtained via questionnaire interviews with 96 pregnant women delivering at the University of North Sumatera Hospital or Maharani Women’s and Children Hospital. Semi-Food Frequency Questionnaires (FFQs) served as the data collection instrument. Non-probability consecutive sampling was employed. Statistical techniques, including Chi-square and Fisher's Exact test, were used for data analysis. Findings indicated a prevalence of inadequate vitamin D intake among mothers (3.125%). The mean daily consumption of vitamin D among expectant women was 19.99 μg/day. Mother's education level did not significantly influence the outcome (p=0.589). Results: The results of this study suggest that there was no significant association between maternal age at pregnancy (p=0. 135), gestational age (p=0. 771), parity (p=0958), and baby's sex (p=0. 448) with birth weight. Conclusion: An observed association existed between the prenatal intake of vitamin D and neonatal birth weight in expectant mothers.

THE EFFECT OF MASSAGE ON SERUM BILIRUBIN LEVELS AND NEONATUS BODY WEIGHT WITH PHOTOTHERAPY

Approximately 25-50% of newborns experience physiological hyperbilirubinemia in the first week of life, 80% occur in premature babies and 60% in full-term babies. Hyperbilirubinemia can be toxic and dangerous, such as encephalopathy. At Ummi Hospital, Bogor, the number of babies born from January to April 2021 was 704, and 11.4% had hyperbilirubinemia and no baby massage intervention had been carried out. Massage for newborns with hyperbilirubinemia reduces bilirubin levels and increases the baby's weight. This study aims to find out whether massage can reduce serum bilirubin levels and increase the weight of hyperbilirubinemia babies who receive phototherapy. This research was conducted in the perinatology room at Ummi Hospital, Bogor, Indonesia with ethical permit no. 02/KEPK/X/2021. The research design used a quasi-experimental pretest-posttest with a control group design, with a sample of 40 hyperbilirubinemia babies. After analysis using the dependent t-test and independent t-test, the results of the study showed that there was no significant difference between body weight before the intervention and after the intervention with p &gt; 0.05 in the intervention group (p=0.054) and the control group (p =0.286). There was a significant difference in bilirubin levels (p&lt;0.05) before and after the intervention in both the intervention group and the control group (p=0.001). Conclusion: Phototherapy alone or combined with massage can reduce serum bilirubin levels in babies. Adding massage to provide comfort to the baby and other benefits.

Assessment of Birth Weight Parameters in Sverdlovsk Region: Preliminary Results

Aim. To define median and large-for-gestational-age birth weight in Sverdlovsk Region and to compare them with the results of a population study conducted in Central Europe.Materials and Methods. We conducted a retrospective analysis of 41,745 women. Inclusion criteria were singleton, full-term pregnancy, absence of fetal malformations, and delivery in a licensed medical organization. Exclusion criteria were multiple pregnancy, signs of chromosomal abnormalities during the antenatal development, congenital malformations, and incomplete examination according to the standard used for normal pregnancy. The results were compared with a similar study carried out in Central Europe.Results. The median weight of newborns at 37, 38, 39, 40, and 41 weeks was 3010, 3180, 3350, 3490, and 3600 g, respectively. “Large for gestational age” (above the 90th percentile) weight at 37, 38, 39, 40, and 41 weeks was 3550, 3720, 3900, 4020, and 4150 g, respectively. These parameters were significantly lower than those in Central Europe. Reproductive age, parity, and metabolic disorders were significant population determinants of birth weight.Conclusion. Birth weight parameters in Sverdlovsk Region differ from those in Central Europe, requiring further research. These data might be used for the correct assessment of the newborns and for development of a territorial strategy for the prevention of fetal growth disorders.

The Influence of Oral Stimulation on the Improvement of Sucking Reflex and Weight Gain in Low Birth Weight Infants (LBW) at Bunda Patimah Primary Clinic

LBW suffer from many problems, including hypothermia, respiratory distress syndrome, intracranial hemorrhage, hyperbilirubinemia, and hypoglycemia because the sucking reflex is weak, resulting in insufficient intake. This weakness in sucking is related to the maturity of the baby's nerve structure and the strength of the mouth muscles. Oral motor skills are one of the most important skills a baby has. The aim of this research is to determine the effect of giving oral stimulation on increasing the sucking reflex and increasing the weight of LBW babies. This research uses a type of quantitative research that uses a pre-test and post-test one group design (Notoatmodjo, 2018), with a Quasi-Experimental design without a control group that compares the evaluation results before and after treatment of respondents. Data were collected using Sucking Reflex and BB Increase observation sheets. The statistical test used is the Wilcoxon Signed Rank Test. The measurement results showed that after giving oral stimulation there was an increase in the sucking reflex and an increase in BW (P value = 0.000), namely an increase in the Sucking Reflex of the majority in the strong category as many as 30 people (93.7%), and those in the minority in the weak category as many as 2 people (6.3%). Meanwhile, in weight gain, the majority in the category increased by 28 people (87.5%), and the minority in the category did not increase by 4 people (12.5%). Based on the research that has been carried out, it was concluded that there is an effect of giving oral stimulation on the Sucking Reflex and Increase in Body Weight in LBW.

Epigenetic modifications in the ferroptosis pathway in cord blood cells from newborns of smoking mothers and their influence on fetal growth

Maternal smoking during pregnancy increases oxidative stress and decreases antioxidant capacity in newborns. Uncontrolled oxidative stress plays a role in fetal development disorders and in adverse perinatal outcomes. In order to identify molecular pathways involved in low fetal growth, epigenetic modifications in newborns of smoking and non-smoking mothers were examined. Low birth weight newborns of mothers who smoked more than 10 cigarettes per day during the first trimester of pregnancy and normal birth weight newborns of mothers who did not smoke during pregnancy were included in the study. DNA was extracted from umbilical cord blood of term newborns. 125 differentially methylated regions were identified by MeDIP-Seq. Functional analysis revealed several pathways, such as ferroptosis, that were enriched in differentially methylated genes after prenatal smoke exposure. GPX4 and PCBP1 were found to be hypermethylated and associated with low fetal growth. These epigenetic modifications in ferroptosis pathway genes in newborns of smoking mothers can potentially contribute to intrauterine growth restriction through the induction of cell death via lipid peroxidation of cell membranes. The identification of epigenetic modifications in the ferroptosis pathway sheds light on the potential mechanisms underlying the pathophysiology of low birth weight in infants born to smoking mothers.

Risks of adverse outcomes and neonatal morbidity in pregnant women with SARS-CoV-2 depending on the trimester of infection

Introduction. COVID-19 in pregnant women adversely affects the course of the disease, pregnancy outcomes, and morbidity in newborns. However, studies on the impact of the gestational age at which SARS-CoV-2 infection occurs on the risk of neonatal morbidity are lacking.Aim. To assess the risks of adverse pregnancy outcomes and neonatal morbidity in newborns depending on the gestational age at which women were infected with SARS-CoV-2.Materials and methods. The study included 215 women infected with SARS-CoV-2 in the first, second, and third trimesters of pregnancy and 50 uninfected pregnant women. Newborns formed corresponding groups. Data for analysis (general clinical, anamnestic, childbirth outcomes, and newborn condition) were obtained from the records of pregnant, laboring, and postpartum women.Results. In 4.7% of women infected in the first trimester, pregnancy was accompanied by spontaneous miscarriage and in 1.9% by ectopic pregnancy development. In 1.9% of women infected in the second trimester, antenatal fetal demise in a full-term pregnancy was detected. Patients infected with SARS-CoV-2 more often underwent cesarean section (31.7%). The median weight and height of newborns from mothers infected with SARS-CoV-2 were lower than in the control group. The Apgar score at the first minute showed no differences, but at the fifth minute, it was lower than in the control group. Newborns from mothers infected with SARS-CoV-2 were more frequently diagnosed with cerebral ischemia (26.3%), motor disorder syndrome (20.7%), and persistent fetal circulation (27.8%). Only in newborns from mothers with SARS-CoV-2 were hypertensive syndrome (13.1%), posthypoxic cardiomyopathy (13.1%), and intraventricular hemorrhages (10.1%) detected. The Apgar score at the first minute in newborns from mothers infected with SARS-CoV-2 in the third trimester of pregnancy was higher compared to infections in the second trimester. Neonatal morbidity in this cohort of newborns was characterized by a high frequency of cerebral ischemia, motor disorder syndrome, hypertensive syndrome, and persistent fetal circulation. Infection in the third trimester increased the risk of neonatal morbidity: cerebral ischemia by 5.6 times, motor disorder syndrome by 13.78 times, hypertensive syndrome by 8.61 times, and persistent fetal circulation by 2.76 times.Conclusion. COVID-19 during pregnancy increases the risks of adverse outcomes and the development of neonatal pathology in newborns. The frequency of their development is associated with the gestational age at which women were infected. Infection of women with SARS-CoV-2 in the first and second trimesters of pregnancy increases the risk of spontaneous miscarriage and antenatal fetal death, in the third trimester – the development of intraventricular hemorrhages and posthypoxic cardiomyopathy in newborns.

Effect of behavior change communication through the health development army on birth weight of newborns in Ambo district, Ethiopia: a cluster randomized controlled community trial

BackgroundPoor behavior change communication on maternal nutrition and health throughout pregnancy is thought to be to blame for Ethiopia’s high rate of low birthweight babies, and this has implications for neonatal morbidity and mortality. The effect of behavior change communication on birth weight in the study district was not examined. This study was to determine whether improving neonatal birthweight using nutrition and health behavior change communication (NHBCC) interventions was successful.MethodsA cluster randomized controlled trial was conducted in the Ambo district of Ethiopia from May 5, 2018–January 30, 2019. At the beginning of the study, 385 women in the 24 intervention groups and 385 women in the 24 control groups were recruited. In the intervention group, health development armies delivered the NHBCC core message every two weeks for four months by grouping pregnant women in specific clusters. Pregnant women in the control group received the routine treatment offered by the healthcare system during their ANC visits. Within 24 h of birth, the birthweights of 302 and 292 neonates in the intervention and control groups, respectively, were measured at the end point of the study. A binary generalized linear model analysis was employed.ResultThe control group had a larger absolute risk of neonates with low birthweight (0.188 vs. 0.079, p < 0.001) than the intervention group. Pregnant women in the intervention group had an absolute risk difference of 10.9% for low birthweight. Pregnant women who received the intervention were 62% less likely to have low-risk birthweight compared to pregnant women who were in the control group (ARR = 0.381, 95% CI: 0.271–0.737).ConclusionNutrition and health behavior change Communication by health development armies improves birthweight. The findings demonstrated that to improve birthweight, NHBCC must be administered to pregnant women in groups via health development armies in their communities.Trial registration numberPACTR201805003366358.

Частота рецидивов ретинопатии недоношенных после введения ингибиторов ангиогенеза (афлиберцепта) в зависимости от массы тела ребенка

Purpose. To study the effectiveness of treatment and the causes of reactivation of retinopathy (ROP) in premature children after aflibercept injection. Material and methods. This study was conducted at the V.F. Voino-Yasenetsky Scientific and Practical Center for Specialized Medical Care in Children from September 2021 to February 2023. The study included 122 premature infants (244 eyes) with ROP who received intravitreal administration of aflibercept. Patients were divided into two groups: the main group (reactivation group) consisted of children who received two or more intravitreal injections of VEGF inhibitors (aflibercept) and the control group consisted of children who received a single intravitreal injection of VEGF inhibitor (aflibercept) with a positive effect. In addition, 3 subgroups were identified depending on birth weight: 37 children had a birth weight of less than 900 g (1st subgroup), 41 children weighed from 900 to 1200 g (2nd subgroup), and 44 children weighed more than 1200 g (3rd subgroup). All patients were monitored for reactivation of ROP after intravitreal injection of aflibercept. Results. Since 2010, we have been using angiogenesis inhibitors in the treatment of ROP. The effectiveness of one dose of aflibercept (0,5 mg/0,0125 ml) is 84,84%. Repeated injections are easily tolerated by patients and increase the effectiveness of treatment to 99,76%. The work is devoted to the analysis of reactivation of ROP after one injection of aflibercept and the study of the reasons for repeated injections. 37/244 eyes (15,16%) showed reactivation of ROP after one injection. Factors influencing the reactivation of retinopathy of prematurity after intravitreal injection of aflibercept include: gestational age, postconceptual age at the 1st injection, birth weight, weight at the 1st injection, birth height, newborn head circumference, head circumference at the 1st injection, newborn chest circumference, history of blood transfusions, body mass index (BMI) at the 1st injection, nuchal cord complications. A large dependence of the reactivation rate on the child’s weight was noted. The birth weight subgroup of less than 900 g had a recurrence rate of 28,38%, followed by the average birth weight subgroup (12,20%) and the subgroup weighing more than 1200 g (6,82%). The reactivation time in the three subgroups of patients was 9,82±5,76, 10,20±3,27 and 12,33±9,24 weeks, respectively. The time of reactivation was also determined by the child’s weight. Reactivation occurred earlier in children with lower weight: in three subgroups of patients, 9.82±5.76, 10.20±3.27 and 12.33±9.24 weeks, respectively. Conclusion. Based on our research, the frequency of reactivation of ROP depends on the weight of the premature baby. A change in weight, even by 100 grams, changes the course of ROP. The lower the birth weight is, the higher the reactivation rate of ROP becomes. Reactivation of ROP occurs 4 times more often (in every 3–4 children) in children with very low birth weight (less than 900 g). The frequency of reactivation is also determined by the weight of the child during the first injection of an angiogenesis inhibitor. Weight also determines the time of reactivation, occurring in children weighing less than 900 or 9–10 weeks after the first injection. If there are risk factors, it is advisable to: carry out simultaneous injections in both eyes, which will increase the dose of aflibercept in total, carefully monitor them in the first 2 months with examination of the fundus, or increase the dose of the drug. Effectiveness can be enhanced by ingesting synergists or impact of physiotherapy. Key words: recurrence, reactivation, retinopathy of prematurity, risk factor, birth weight, intravitreal injection, aflibercept, vascular endothelial growth factor