The potential use of the proton-antiproton annihilation reaction as a driver for an inertially confined, magnetically insulated fusion plasma with application to advanced space propulsion is examined. The fusion scheme utilized is the magnetically insulated inertial confinement fusion (MICF) concept which combines the favorable aspects of both inertial and magnetic fusions into one. Using an appropriate set of governing equations for the fusion plasma, along with those that detail the annihilation reactions and the energy deposition by the annihilation products including contributions from muon catalysis, we calculate the energy gain for the system as well as the amount of antihydrogen needed to ignite the plasma. We find about 13 ng of antihydrogen are needed to supply a megajoule of energy to the plasma, and about 10 g will be needed for a 220-mT space vehicle to make a one-way trip to Mars in about 2 months. I. Introduction I N several previous publications1-3 we examined the potential use of the magnetically insulated inertial confinement fusion (MICF) concept as a propulsion device that could be utilized in solar explorations and/or interplanetary travel. The concept in question combines the favorable aspects of both magnetic and inertial fusions in that physical containment of the hot plasma is provided by a metallic shell while its thermal energy is insulated from the material wall by a strong, self-generated magnetic field as illustrated in Fig. 1. Unlike the conventional implosion-type inertial fusion schemes, energy production in this approach does not require compression of the fusion fuel to many times solid-state densities and simultaneous delivery of energy to the core to initiate the burn. Instead the fusion plasma is created through wall ablation by an incident laser beam that enters the target through a hole. The same laser gives rise to the strong magnetic field through a process known as the thermoelectric effect, whereby it can be shown that such a field can be generated in a hot plasma when its density gradient is perpendicular to its temperature gradient. We have seen that MICF is capable of producing specific impulses of several thousand seconds and thrusts of tens of kilonewtons that would allow round trips to Mars, for example, to be made in relatively short periods (a few months) even when the massive power supply system for the laser driver is carried on board. It is clear that such travel times can be substantially reduced if the power supply component is eliminated from the dry weight of the vehicle. Several recent studies4 have proposed beaming the needed energy from an Earth-orbiting space station, but it is evident that a more reliable performance can be assured if a compact energy source is taken along. Clearly no source can match that of matter-antima tter annihilation reactions since such a fuel (e.g., anti-hydrogen) possesses the largest specific energy, i.e., energy per unit mass, provided, of course, that the technology for producing, storing, and manipulating such