Research on two-phase channel flow in microgravity has extensively investigated flow regimes, pressure drop, and heat transfer during evaporation and condensation processes over several decades. This literature has been primarily motivated by the goal of enabling future space applications for two-phase thermal management systems, among them vapor compression refrigeration cycles. However, relative to the number of two-phase channel flow experiments, research on vapor compression cycles in microgravity has been almost non-existent. This paper reviews two-phase flow research and compares key outcomes with those from system-level measurements obtained from recent testing of a vapor compression cycle at varying inclination angles and on parabolic flights. Previous two-phase channel flow experiments have resulted in several microgravity-specific flow regime maps and have also generally found reduced condensation heat transfer coefficients in microgravity as compared to normal gravity. The flow pattern map of Jayawardena et al. (1997) and generally reduced condensation heat transfer are confirmed by the vapor compression cycle experiments. Regarding evaporation heat transfer coefficients and friction factors, there is not a consensus in the literature on the effects of microgravity in two-phase channel flows. Similarly, the system-level experiments do not show repeatable increases or decreases for those parameters. Lastly, the dependence of system-level behavior on orientation with respect to gravity was tested by performing dynamic inclination experiments, where the inclination angle was changed every 2 min by a 90-degree increment. These tests reveal an increased relative dependence of the vapor compression cycle to orientation with decreasing mass fluxes, in line with two-phase channel flow research that has generally shown that increasing the flow inertia acts to mitigate various flow instabilities and dependence on orientation. However, inclination testing with longer locking times per angle showed a constant relative dependence of the vapor compression cycle to orientation changes.