Tailless Unmanned Aerial Vehicles (UAVs) offer several advantages over their conventional counterparts, including enhanced maneuverability, higher durability, and better stealth. However, they are challenging in their stability and control due to the absence of stabilizing and control surfaces that typically exist in conventional empennage. A crucial process for analyzing the tailless UAVs’ stability/performance characteristics and determining/validating their flight control parameters is done via the modeling and simulation of flight dynamics. This paper presents a comprehensive and systematic procedure for investigating the flight dynamics of a tailless UAV, including modeling, simulation, analytical verification, and flight testing, while also explaining the interconnections among these elements. It also addresses the common challenge of limited accessibility of UAV essential data through using diverse analytical, empirical, and experimental methods. First, a rapid and effective first-principles modeling approach is introduced to simulate the nonlinear six-degree-of-freedom flight dynamics of a small tailless UAV case study. The modeling process follows a modular framework where well-defined experiments and commercial of-the-shelf software, tools, and sensors are employed to build the necessary sub-models, including geometric, mass–inertia, aerodynamic, propulsion, and actuator models. Then, all sub-models are integrated into a simulation environment to allow the prediction of the UAV dynamic response obtained from the given control inputs. The developed flight dynamic model is subjected to a thorough verification process to ensure its integrity and proper functionality by comparing the simulated trim and natural flight modes with the calculated analytical results. Finally, a set of specific flight tests are performed to validate the developed simulation model and verify relevant performance characteristics for the case-study UAV. The results show that the proposed approach provides a systematic and straightforward method for examining the flight dynamics of small tailless UAVs with reasonable accuracy.