The literature documents that cancer poses significant burden to patients, and that cancer survivors are particularly vulnerable to access to care due to financial reasons. No studies, however, have assessed the potential productivity loss and out-of-pocket costs. Therefore, the purpose of this study aimed to estimate the impact of financial access barriers on cancer survivors’ productivity loss and out-of-pocket costs. A retrospective, pooled cross-sectional study was conducted using data from the National Health Interview Survey (NHIS) between 2010 and 2017. Measurement of financial access barriers was based on respondents’ "yes” response to any of the following survey prompts: “couldn't afford medical care”, couldn't afford dental care”, “couldn't afford eyeglasses”, “couldn't afford mental health care”, “couldn't afford follow-up care”, or “couldn't afford specialists.” Productivity loss was measured by lost workdays in the past 12 months. An ordered logistic regression was used to determine the impact of financial access on patients’ out-of-pocket costs (less than $2,000, $2,000 – 4,999, $5,000 or more). In addition, a negative binomial regression was implemented to estimate the impact on productivity loss caused by financial access barriers. A total of 8,818 and 22,338 cancer survivors were identified out of 717,513 respondents for assessing the impact on productivity loss and out-of-pocket-costs, respectively. The financial access barrier was associated with increased productivity loss compared to those without barriers, [IRR= 1.16, (95% CI: 1.00 to 1.35, P=0.045)]. Not surprisingly, increased financial barriers were associated with higher patients’ out-of-pocket costs, [OR= 1.56, (95% CI: 1.73 to 1.80, P =0.007)]. Cancer survivors with financial access barriers are more likely to lose productivity and pay a higher level of out-of-pocket costs, suggesting inequality in health care access can further exacerbate the societal burden of cancer in addition to direct medical costs.