This study investigated the strategies for mitigating challenges facing collaboration between technical colleges and industries for skill acquisition in motor vehicle mechanic works in Edo State. Three research questions and one hypothesis tested at 0.05 level of significance were used. The study adopted a descriptive survey research design with a population of 80 respondents, which comprised technical teachers and managers of automobile industries in Edo State. The entire population was adopted as the sample because it is of manageable size. A structured questionnaire with 17 items arranged in clusters was used as instrument for data collection. The instrument was validated by three experts. Cronbach alpha coefficient formula was used test the reliability of the instrument and it yielded an overall coefficient of 0.85. The findings of the study revealed that collaboration between technical colleges and industries for skill acquisition is facing a lot of challenges, such as industry’s unwillingness to support students’ industrial work experience scheme, amongst others. Based on the findings, it was recommended, amongst others, that industries should establish school-based workshop as a strategies for improving collaboration between technical colleges and industries for skills acquisition.