Industry Survey Research Articles

The Current State of Biotransformation Science - Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends.

Embedded within the field of drug metabolism and pharmacokinetics (DMPK), biotransformation is a discipline that studies the origins, disposition, and structural identity of metabolites to provide a comprehensive safety assessment, including the assessment of exposure coverage in toxicological species. Spanning discovery and development, metabolite identification (metID) scientists employ various strategies and tools to address stage-specific questions aimed at guiding the maturation of early chemical matter into drug candidates. During this process, the identity of major (and minor) circulating human metabolites is ascertained to comply with the regulatory requirements such as the Metabolites in Safety Testing (MIST) guidance. Through the International Consortium for Innovation and Quality in Pharmaceutical Development (IQ), the "Translatability of MetID In Vitro Systems Working Group" was created within the Translational and ADME Sciences Leadership Group. The remit of this group was to objectively determine how accurate commonly employed in vitro systems have been with respect to prediction of circulating human metabolites, both qualitatively and quantitatively. A survey composed of 34 questions was conducted across 26 pharmaceutical companies to obtain a foundational understanding of current metID practices, preclinically and clinically, as well as to provide perspective on how successful these practices have been at predicting circulating human metabolites.The results of this survey are presented as an initial snapshot of current industry-based metID practices, including our perspective on how a harmonized framework for the conduct of in vitro metID studies could be established. Future perspectives from current practices to emerging advances with greater translational capability are also provided.

The Role of Automation in Enhancing Cybersecurity: a Technical Analysis

Intelligent automation, a convergence of artificial intelligence (AI), machine learning (ML), and robotic process automation (RPA), is reshaping modern business operations across various sectors. This article examines the transformative impact of intelligent automation on organizational efficiency, cost structures, and innovation capabilities. Recent industry surveys indicate a significant increase in adoption rates, with 67% of business leaders implementing intelligent automation at scale in 2023, up from 48% in 2020. The integration of AI and ML with RPA has enabled businesses to automate complex, cognitive tasks, leading to an average 35% reduction in operational costs and a 50% improvement in process cycle times. While challenges such as data privacy, ethical considerations, and workforce reskilling persist, the potential benefits of intelligent automation are substantial. This article explores quantifiable impacts across industries, examines real-world case studies, and anticipates future trends including hyperautomation, autonomous decision-making, and integration with emerging technologies like blockchain and edge computing. The article concludes that strategic implementation of intelligent automation solutions will be crucial for organizations to maintain competitiveness and drive innovation in the increasingly digital business landscape.

Stakeholders’ perceptions of and willingness to pay for circular economy in the construction sector

Adopting Circular Economy practices in the construction industry can help reduce greenhouse gas emissions. However, many barriers exist to adoption, and current perceptions of and willingness to pay for circularity have yet to be quantified. This study seeks to understand the various perceptions of circularity in the construction industry, characterize uncertainties and risks, and identify economic incentives and opportunities that could accelerate circular adoption via an industry survey of three stakeholder groups. 58 stakeholders filled out part of the survey, and 42 stakeholders completed the majority of questions. Real estate developers are willing to pay an average premium of 10% for construction costs if there’s a minimum embodied carbon reduction of 53%. Design and construction professionals and material suppliers were also surveyed. Reasons for adopting circular practices were primarily driven by client, design team, and net zero goals. The results of this survey begin to characterize the economic landscape of what is needed for a circular transition in the built environment.

OPEN-PIT LIMESTONE MINING AREAS MAPPING AND ASSESSMENT USING RANDOM FOREST ALGORITHM FOR SUSTAINABLE DEVELOPMENT

Limestone excavation is prone to land use/cover change, which impacts the ecosystem. The objective of this paper is to use a remote sensing dataset and the Quantum Geographic Information System (QGIS) to map and assess active captive limestone mining sites at the Yerraguntla in the YSR Kadapa district, Andhra Pradesh, India, for the year 2019. In this paper, the Limestone mining area was assessed as 379.57 ha with an overall accuracy of 95.79%, user accuracy of 97.25%, producer accuracy of 99.18%, and kappa coefficient of 0.957 by analyzing Sentinel-2A imagery dataset with Random Forest (RF) classifier. The findings were assessed in 2019 using very high-resolution (<1m) Google Earth images (486.47 ha) from Google Earth Pro and industrial field survey reports (487.10 ha). This research helps Limestone mine owners and Environmental engineers implement eco-friendly mining operations and monitor mining progress at low cost with less human efforts for sustainable development.

Reducing the cost of home energy upgrades in the US: An industry survey

Decarbonizing the US residential building stock requires a substantial acceleration in home energy upgrades. Numerous barriers exist to accelerating adoption of efficient and electric building technologies, but foremost among these is high upfront costs. This study uses an industry survey delivered to a sample of home energy professionals to examine promising cost reduction strategies across a range of project types, including HVAC, water heating, and envelope/insulation projects. The survey included quantitative and qualitative questions to collect evidence on the estimated cost reduction potential of these strategies and their likelihood of use in the construction industry. The 167 survey respondents included contractors, energy consultants, architects, manufacturers, and others with experience in delivering energy upgrades in single-family and multifamily buildings in the US. Results show that significant cost reductions are achievable by minimizing additional infrastructure costs (such as replacing electric panels), streamlining project planning/management, and deploying innovations that simplify installation. We find that for a typical deep retrofit project, including heat pumps for space and water heating in addition to envelope upgrades, the strategies could result in a total installed cost reduction of nearly 50 %, dramatically improving the customer economics of such a project. This research makes a novel contribution to the literature on strategies to reduce the costs of residential retrofits. We discuss how our study's insights on the highest-value cost reduction strategies for home energy upgrades can further accelerate their uptake in the US housing stock.

An emerging market? The European Maritime Industry’s View on Autonomous Maritime Systems: A Survey

Abstract Autonomous Maritime Systems have significantly emerged in maritime research over the past decade. But how is this technology adapted by the maritime industry in business applications? Based on a product and application-focused literature review as well as an industrial survey among 52 companies, this paper gives insights into the industrial’s interest in this emerging technology for different maritime segments, their prioritized use cases as well as the main barriers for the emerging market according to the European Maritime Industry. Hereby, it assesses the technology adoption rate specifically for different segments, i.e. Ship Operators, Manufacturers, Ports, Shipbuilding, Offshore and (Hinterland) logistics.

Mergers and Acquisitions in the Digital Age: The Role of Technology in Streamlining Financial Integration

Abstract: This comprehensive article explores the transformative role of technology in streamlining financial integration during mergers and acquisitions (M&A) in the digital age. It examines how advanced technological solutions, including cloud-based Enterprise Resource Planning (ERP) systems, automated reconciliation tools, and artificial intelligence (AI) and machine learning (ML) applications, are revolutionizing traditional M&A processes. The paper delves into the impact of these technologies on consolidating financial data, enabling real-time analysis, reducing manual errors, and providing predictive insights for risk assessment and opportunity identification. It also discusses best practices for successful financial integration, emphasizing the importance of pre-merger due diligence, phased integration approaches, and robust cybersecurity measures. Furthermore, the article investigates emerging trends and future prospects in technology-driven M&A, including the potential of blockchain, advanced analytics, and quantum computing to further enhance integration processes. Drawing on recent research and industry surveys, this study highlights the critical role of technology in realizing M&A potential, improving deal outcomes, and creating strategic value in an increasingly complex business environment. The findings underscore the necessity for organizations to embrace technological advancements to remain competitive in the evolving landscape of corporate mergers and acquisitions.

Examining and Comparing Structural Changes Across Different Industries in India: Evidence from the Annual Survey of Industries

Examining and Comparing Structural Changes Across Different Industries in India: Evidence from the Annual Survey of Industries

Multicriteria Analysis of Innovation Ecosystems and the Impact of Human Capital and Investments on Brazilian Industries

Innovation is one of the main factors associated with industrial growth, as it contributes to increased productivity, sustainability, and international competitiveness. There is a certain degree of complexity in measuring innovation, since there are various metrics for this purpose, and each sector of the economy handles it differently. In Brazil, the Industrial Survey of Technological Innovation (PINTEC) was developed to construct sectorial indicators on innovation activities. Based on these data, this paper investigates how ten sectors of the economy performed during two historical series (2011 to 2014 and 2014 to 2017) considering five criteria linked to the innovation process and the impact of qualified human capital. The problem is analyzed in light of multicriteria decision analysis (MCDA), using preference ranking organization methods for enrichment evaluation (PROMETHEE II) to provide a ranking of Brazilian industrial sectors. The results show how the sectors have changed over the years, highlighting that innovation expenditure proved crucial in measuring companies’ commitment to innovation, but also show that a highly qualified workforce emerged as a leading factor. Furthermore, the research presents which criteria have contributed positively and negatively to each sector, which can serve as drivers for policy formulation to strengthen the Brazilian industry.

The Myth of Deglobalization: Multinational Corporations in an Era of Growing Geopolitical Rivalries

Globalization is past its peak, we are told. The rise of populist anti-globalization movements and the return of geopolitical rivalries among great powers in the 2010s has put an end to free-wheeling corporate global capitalism. Or has it? This article summons available data on cross-border corporate investments at the level of countries (balance of payments), firms (subsidiaries and affiliates), and corporate managers (industry surveys). It pays special attention to the period between 2015 and 2021, which spans the election of President Trump and the outbreak of the Covid-19 pandemic that have unsettled global politics. We analyze global patterns in foreign direct investment positions and in particular the evolution of investments by US corporations in China, arguably a “most likely case” for deglobalization. Our analyses find no evidence that economic cross-border integration is in decline. The global allocation of corporate investments across the world’s major economic regions has remained stable. US corporations have not notably reduced their global activities. If anything, their aggregate investment position in China has increased during the Trump administration’s trade war. Overall, the results cast empirical doubts on prominent narratives about the state of the global economy. Geoeconomic transformations in world economic infrastructures may well be underway, but they are better understood as new and adapted forms of internationalization rather than the end of globalization.

Navigating Climate Change: Alberta’s Carbon Program for Sustainable Agriculture

In 2021, the Government of Alberta launched the carbon program initiative to evaluate environmental practices and greenhouse gas reduction strategies in the agricultural sector. The program has produced various technical reports, policy briefing papers, industry surveys and roundtables. This policy paper consolidates the findings of the research. It presents an analysis of Alberta’s greenhouse gas emission profile, historical trends and the policy framework, as well as an examination of mitigation strategies such as carbon pricing and their effectiveness in Alberta’s agricultural system. The key question addressed in this paper is how Alberta can continue to support its thriving agricultural industry while responding to the federal and global calls to significantly reduce its methane and nitrous oxide emissions and fulfil Canada’s climate commitments. The paper also outlines the obstacles that producers encounter when implementing these strategies, as well as the limitations of the current emission estimation methodology in measuring the impact. To effectively address the challenges of emission mitigation in Alberta’s agriculture sector, a co-ordinated approach at both the federal and provincial levels is crucial. The paper concludes with the following recommendations that outline specific actions to help reduce uncertainties and support producers in implementing best management practices (BMPs) to lower greenhouse gas emissions.

Beyond MABEL: An Integrative Approach to First in Human Dose Selection of Immunomodulators by the Health and Environmental Sciences Institute (HESI) Immuno-Safety Technical Committee (ITC).

Administration of a new drug candidate in a first-in-human (FIH) clinical trial is a particularly challenging phase in drug development and is especially true for immunomodulators, which are a diverse and complex class of drugs with a broad range of mechanisms of action and associated safety risks. Risk is generally greater for immunostimulators, in which safety concerns are associated with acute toxicity, compared to immunosuppressors, where the risks are related to chronic effects. Current methodologies for FIH dose selection for immunostimulators are focused primarily on identifying the minimum anticipated biological effect level (MABEL), which has often resulted in sub-therapeutic doses, leading to long and costly escalation phases. The Health and Environmental Sciences Institute (HESI) - Immuno-Safety Technical Committee (ITC) organized a project to address this issue through two complementary approaches: (i) an industry survey on FIH dose selection strategies and (ii) detailed case studies for immunomodulators in oncology and non-oncology indications. Key messages from the industry survey responses highlighted a preference toward more dynamic PK/PD approaches as in vitro assays are seemingly not representative of true physiological conditions for immunomodulators. These principles are highlighted in case studies. To address the above themes, we have proposed a revised decision tree, which expands on the guidance by the IQ MABEL Working Group (Leach et al. 2021). This approach facilitates a more refined recommendation of FIH dose selection for immunomodulators, allowing for a nuanced consideration of their mechanisms of action (MOAs) and the associated risk-to-benefit ratio, among other factors.

Author language and communication preferences, and familiarity with global publication guidelines, for English-language industry-sponsored publications in Asia-Pacific: insights from a cross-sectional survey

Objective To understand current practices and challenges for collecting author feedback for English-language, industry-sponsored publications in Asia-Pacific (APAC), and the implications for adherence to international publication guidelines. Methods A cross-sectional, internet-based survey of industry (‘internal’) authors (17 questions) and publication professionals (18 questions) supporting publications in APAC, conducted between November 18 and December 4, 2022. Results Overall, 142 survey responses were received, of which 94 (66%) were complete and included in the analysis (33 internal authors, 61 publication professionals). Almost half (45%) of internal authors preferred a non-English language for providing feedback on publications, and most (70%) would use this language whenever possible. Internal authors favored written (91%) versus spoken (73%) English, and email was the preferred mode of communication. Publication professionals said they have observed qualitative differences when authors provide feedback in a preferred non-English language versus English. Many agreed that authors tend to provide more substantive or critical feedback when they can respond in their preferred non-English language. Internal authors had low self-assessed familiarity with key publication guidelines, while most publication professionals had a moderate or high self-assessed familiarity. The main barriers to application of publication guidelines, as rated by publication professionals, were that external authors in APAC are not familiar with global publication guidelines and do not always provide feedback/responses in writing. Conclusion It is important to consider the diverse language, cultural, and communication preferences of individuals involved in English-language publication development in APAC, and to ensure that authors are aware of current publication guidelines and best practices.

A Global Industry Survey on Post-Approval Change Management and Use of Reliance.

Post-approval changes (PACs) to the control and manufacturing processes of medicines and vaccines are routinely undertaken and critical to enable both innovation and secure sustained supply. In a world of global supply chains, the existence of divergent national PAC requirements (with additional countries introducing new requirements with potential differences) and other factors including document preparation and response timelines, can lead to long delays in approval (of up to 3-5years) increasing the risk of disruption and shortages.We undertook an Industry survey in 2023 to assess implementation of ICH Q12, PAC procedures (change categorisation and review timelines) and use of reliance mechanisms across different countries (9 selected ICH Members and 19 Observers). Although this survey revealed limited implementation of Q12 in ICH Member countries, when comparing the data collected with those of a previous survey performed in 2020, we observed a broader adoption of risk-based approaches to variation categorisation (in all countries). This, however, was not reflected in improved timelines for approval.With regards to ICH Q12 adoption, the uptake of Post-Approval Change Management Protocols (PACMPs) was unchanged (with only one country reporting in-use) and implementation gaps were evident for Established Conditions (EC) and the Product Life Cycle Management document (PLCM). The survey found greater awareness of ICH Q12 and its tools compared to 2020, potentially illustrating the positive impact of training efforts. This illustrates the challenges being faced to broaden its implementation and use globally.In the same Industry survey, we also assessed PAC processes across different international countries. Long unpredictable timelines were the major concern across the countries surveyed together with limited capacity of the regulators. Four different CMC changes were selected and categorized by the respondents according to current knowledge of national classifications and timelines in the selected countries and compared with a reference classification and timeline from the European Medicines Agency and the World Health Organisation. This highlighted the lack of harmonisation of many countries with EU/WHO requirements, especially within the ICH Observer group.Last, this survey showed that some use of unilateral forms of reliance to Reference Authorities for PACs is starting. This is a mechanism all countries can employ, regardless of convergence of requirements and expertise, to enhance capacity building and reduce duplication of reviews, streamline variations approval, whilst accelerating patient access to innovation and securing supply.

Empirical evidence of Goodwin’s growth cycle in the Indian organised manufacturing sector

PurposeThe aim of the paper is to investigate Goodwin’s growth cycle in the Indian organised manufacturing industries.Design/methodology/approachThe methodology is based on bi-variate differential equation, econometrics model like log-linear regression and Autoregressive Distributed Lag model. An empirical investigation is conducted on data from the Annual Survey of Industries from 1980 to 2018 time period.FindingsThe results indicate that though the original Goodwin model estimates deviated from data estimates, its modified (neo-Goodwin) model are found to be equivalent to the data estimates. Moreover, in contrast to the original model, the capital accumulation rate (investment to profit ratio) is not assumed to be unitary in the modified Goodwin model. Furthermore, the labour market-led and cost effect conditions of the Goodwin cycle are empirically verified by investigating the interdependency between employment rate and wage share. Lastly, the short- and long-run Goodwin cycles are observed to be moving in anti-clockwise direction in the employment rate and wage share bi-dimensional plane, thus confirming the existence of profit-led distribution where wage share continuously reducing with high employment.Research limitations/implicationsThis study opens the discussion on application of capitalistic model in the emerging economy and also suggests to incorporate some theoretical models like Kaldorian, Keynesian, Kaleckian or Schumpetrian into the Goodwin cycle.Originality/valueThis is the first paper which empirically examines the capitalistic nature of Indian organised manufacturing industries through the lens of Goodwin growth cycle and then extend it to the Neo-Goodwin model by relaxing one of the unrealistic assumption regarding unitary investment to profit ratio.

Market demands vs. scientific realities: A comparative analysis in the context of BIM-based and user-centred lighting control

Real utilisation patterns often only become apparent when a building is put into operation. Since planning is therefore based on several assumptions, the potential of building technology is often limited. Post-occupancy evaluations offer the potential to adapt operation to real usage patterns and draw conclusions for future planning, thereby improving performance. Although solution approaches are available in the literature, this potential is currently hardly being utilised. A survey in the construction industry is therefore used to compare market requirements with existing solution concepts. The results emphasise the relevance of auto-commissioning, contractual agreements on performance evaluation and the coupling of digital twins with post-occupancy evaluations. A stronger anchoring of the control industry in BIM is proving to be necessary for better cross-disciplinary collaboration between all parties involved. Even though the focus of this study is on lighting, the most important findings are in principle transferable to other trades.

An investigation into the extent to which sustainable product development practices are implemented in manufacturing companies

In recent decades, the pressure from regulations and consumers for products with enhanced sustainability performance has escalated the implementation of sustainability actions by companies. For manufacturing companies specifically, Sustainable Product Development (SPD) is a key approach for reducing the sustainability impacts of the developed products, across their entire life cycle. Despite the availability of wide range of management practices for SPD to support embedding sustainability into the product development process, the extent of their application by companies remains underexplored. To fulfil this gap, an industry survey was conducted to investigate the capability of manufacturing companies to apply a consolidated set of 61 SPD management practices. The overall results which comprised 20 companies across 14 sectors revealed that most of the practices are still applied at a low capability level by most companies. This result indicates a large theory-practice gap particularly in understanding the influence of the type of business, variation in capability levels across different business processes and stages of the product development that influence the successful implementation of sustainability actions in companies. Hence, stronger collaboration between the academia and industry sectors are essential to transform new knowledge into actionable strategies.

3D Structure of Low‐Angle Normal Faults and Tectono‐Sedimentary Processes of Nascent Continental Core‐Complexes in the SE South China Sea

AbstractThis contribution explores the formation and evolution of hyper‐extended basins, associated with the early stage of core complex formation, controlled by low‐angle normal faults active at <30°. Based on a high‐resolution industrial 3D seismic reflection survey along the southern margin of the South China Sea (SCS) (Dangerous Grounds), we mapped and analyzed the 3D geometry of low‐angle normal fault systems and the related stratigraphy. Two main hyper‐extended basins were documented, filled by up to 6 km of sediments including pre‐ to post‐rift sequences. The observed normal faults on depth migrated seismic sections show an average dip angle of <30° and appear planar, characterized by continuous reflections with no clear steepening at depth and sole‐out on distinct decollement levels. Detailed fault surface mapping reveals the occurrence of km‐scale corrugations together with large wavelength undulation. The formation of these hyper‐extended basins is associated with polyphased syn‐rift infill during the development of the low‐angle normal faults. The first syn‐rift sequence appears as chaotic and discontinuous packages that has been dismembered and fragmented during the activity of low‐angle normal faults. The second syn‐rift package shows unexpected sedimentary wedges developing successively toward the footwall and the hangingwall. This geometry results from the interplay between the main low‐angle normal fault and antithetic faults defining a so‐called extensional fishtail. The deep structure of these basins shows nascent domes with limited evidence of magmatism. Eventually, these basins likely capture the earliest stage of core complex development in the proximal margin of the southern SCS.

Developing Standard BIM Execution Plans for Complex Construction Projects

This study addresses the critical need for standardizing building information modeling (BIM) execution plans (BEPs) in the architecture, engineering, construction, and operations (AECO) sector. Through the analysis of 36 BEP documents from international organizations, we have identified crucial components and put forth a comprehensive framework with the objective of improving digital transformation and collaboration in intricate construction projects. This study utilizes scientometric analysis to chart the development of BEP standards and incorporates empirical data from industry surveys to verify the suggested framework. The results of our research emphasize the advantages of using standardized building execution plans (BEPs) to decrease inefficiencies and enhance project outcomes. This makes a substantial contribution to the field of building information modeling (BIM) implementation.

Assessing the net financial benefits of employing digital endpoints in clinical trials.

In the last few decades, developers of new drugs, biologics, and devices have increasingly leveraged digital health technologies (DHTs) to assess clinical trial digital endpoints. To our knowledge, a comprehensive assessment of the financial net benefits of digital endpoints in clinical trials has not been conducted. We obtained data from the Digital Medicine Society (DiMe) Library of Digital Endpoints and the US clinical trials registry, ClinicalTrials.gov. The benefit metrics are changes in trial phase duration and enrollment associated with the use of digital endpoints. The cost metric was obtained from an industry survey of the costs of including digital endpoints in clinical trials. We developed an expected net present value (eNPV) model of the cash flows for new drug development and commercialization to assess financial value. The value measure is the increment in eNPV that occurs when digital endpoints are employed. We also calculated a return on investment (ROI) as the ratio of the estimated increment in eNPV to the mean digital endpoint implementation cost. For phase II trials, the increase in eNPV varied from $2.2 million to $3.3 million, with ROIs between 32% and 48% per indication. The net benefits were substantially higher for phase III trials, with the increase in eNPV varying from $27 million to $40 million, with ROIs that were four to six times the investment. The use of digital endpoints in clinical trials can provide substantial extra value to sponsors developing new drugs, with high ROIs.