The global COVID-19 outbreak at the beginning of 2020 has had a great impact on many global industrial chains, and triggered a systematic risk of chain breakage. By studying the actual supply chain strategy and the change trend of supply chain strategy in representative countries and enterprises, this research predicts the short-term, medium-term and long-term impact of COVID-19 epidemic on global supply chain. Among them, the short-term and medium-term impacts include encouraging enterprises to improve the flexibility of supply chain by constructing supply chain digital platform, supply chain diversification system and supply chain early warning system; in the medium and long term, the global supply chain layout will change from globalization to regionalization, and some high-end manufacturing industries will have a backflow trend. Our government needs to establish an early warning system of industrial supply chain security as soon as possible in the short term, promote the industrial Internet platform in the short and medium term, continuously support the healthy and efficient development of the supply chain, and adjust the industrial layout in the medium and long term to cope with the global supply chain adjustment.