e23116 Background: Most cancer centers rely on fundraising to support their clinical mission. However, the type and mission of companies sponsoring such events is not well known. Our goal was to determine if the source of philanthropy varies in different regions of the USA. Methods: Institutional websites and search engines were used to identify one signature fundraising event per NCI-designated Comprehensive Cancer Center. An event website and occurrence between January 2021 and January 2025 was required for inclusion. Principal corporate donors were inferred based on level of sponsorship (i.e., presenting, gold, etc.) or order of prominence. These were collapsed into 5 categories based on the Global Industry Classification Standard: 1) Consumer 2) Financial-Real Estate 3) Healthcare 4) IT-Communications, and 5) Materials-Industrial-Energy-Utilities. Chi-square analysis was used to compare sponsorship across 4 regions of the USA and Fischer’s exact test was used to make post-hoc exploratory analyses. All non-major corporate sponsors were excluded. Results: A total 493 corporate sponsorships were identified for 38 events that met inclusion criteria. Specifically, these were run/cycle/walks in 16 (42%), dinner galas in 15 (40%), concerts in 2 (5%) and other in 3 (8%). Most commonly, sponsors came from the Consumer (27%) and Healthcare (23%) industries. The relative number of companies in each category varied significantly among different regions (p < 0.001). Post-hoc testing revealed the health industry favored the northeast region compared to other regions for sponsorship (p = 0.0025). Conclusions: Charity events are philanthropically supported by different corporate sectors in different regions of the United States. This information can help cancer centers become more efficient at fundraising. [Table: see text]