Scale formation caused by the precipitation of sparingly soluble salts such as CaCO3 is a major challenge in membrane-based desalination technologies, leading to flux decline and increased energy costs. Surface modification using nanoscale coatings is a promising approach to mitigate membrane fouling. In this work, we demonstrate the antiscalant properties of a MoS2-carbon quantum dot (CDs@MS-NF) composite with a nanoflower-like structure coating for suppressing calcite scale formation. The CDs@ MS-NF coating was synthesized via a solvothermal method and applied to a polyamide reverse osmosis membrane surface using an in-situ growth technique. Characterization revealed uniform coverage of MoS2 nanosheets decorated with CDs@MS-NF on the membrane surface. Static fouling tests simulating calcium sulfate scaling conditions were conducted to evaluate the antifouling performance. The CDs@MS-NF coated membrane exhibited a flux reduction of only 11 %, compared to 34 % for the unmodified membrane after 24 hours. Further analyses showed a calcite nucleation induction time of 5.2 hours and a critical scaling threshold of 1.8 times the solubility for the CDs@ MS-NF coated membrane, indicating significant inhibition of scale formation. We hypothesize that the CDs@ MS-NF nanocomposite layer alters surface charge and wettability while also catalyzing redox reactions to hinder calcite crystal growth. This work demonstrates that multifunctional two-dimensional nanocomposite coatings can effectively mitigate membrane scaling through multiple synergistic mechanisms.