Induction Of Long-term Allograft Survival Research Articles

Induction of long-term allograft survival by anti-immunoglobulin, anti-thymocyte serum, and donor antigen

Heterologous anti-immunoglobulin (AI) is a potent immunosuppressant which prolongs H-2-incompatible skin graft survival and in conjunction with anti-thymocyte serum (ATS) results in greater prolongation of graft life than either antiserum used alone. Combination treatment of recipient mice with AI, ATS, and donor spleen cells produces long-term allograft survival to the lifetime of the host and can result in specific immune unresponsiveness of sufficient strength to permit acceptance of a second set graft.