Polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCDD), "novel" brominated flame retardants (NBFRs), organophosphate esters (OPEs), polycyclic aromatic hydrocarbons (PAH), perfluoroalkyl substances (PFAS), and polychlorinated biphenyls (PCBs) were measured in a composite sample of dust from the International Space Station (ISS). Notwithstanding the unique environment from which the dust originated, while concentrations of all target compound classes frequently exceeded the median values in terrestrial indoor microenvironments in the US and western Europe, ISS dust concentrations were generally within the terrestrial range. The relative abundance of the three HBCDD diastereomers is dominated by γ-HBCDD (96.6% ΣHBCDD). This matches very closely with the commercial mixture added to materials and contrasts with the diastereomer distribution observed in most terrestrial indoor dust samples (in which γ-HBCDD is typically ∼60-70% ΣHBCDD). This suggests conditions inside the ISS do not favor the previously reported photolytically mediated formation in dust of α-HBCDD. Also of note, the concentration of perfluorooctanoic acid (PFOA) in ISS dust (3300 ng/g) exceeds the maximum reported (1960 ng/g) in a 2008 survey of dust from US child daycare centers and homes. This may reflect the widespread use of waterproofing treatments in the ISS to prevent microbial growth. Our findings can inform future material choices for manned spacecraft such as the ISS.