BackgroundPerception of health risk can influence household rules, but little is known about how the perception of harm from cannabis secondhand smoke (cSHS) is related to having a complete ban on in-home cannabis smoking. We examined this association among a nationally representative sample of United States adults.MethodsRespondents were 21,381 adults from the cross-sectional Marijuana Use and Environmental Survey recruited from December 2019-February 2020. Perceived harm of cSHS exposure (extremely harmful, somewhat harmful, mostly safe, or totally safe) and complete ban of cannabis smoking anywhere in the home (yes or no) were self-reported. Logistic regression for survey-weighted data estimated covariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between perceived harm of cSHS and complete ban on in-home cannabis smoking. Stratified subgroup analyses (by cannabis smoking status, cannabis use legalization in state of residence, and children under age 6 living in the home) were conducted to quantify effect measure modification of the association between perception of harm and complete ban.ResultsA complete ban on in-home cannabis smoking was reported by 71.8% of respondents. Eight percent reported cSHS as “totally safe”; 20.5% “mostly safe”; 38.3% “somewhat harmful”; and 33.0% “extremely harmful”. Those who reported cSHS as “extremely harmful” had 6 times the odds of a complete ban on in-home cannabis smoking (OR = 6.0, 95%CI = 4.9–7.2) as those reporting smoking as “totally safe”. The odds of a complete ban were higher among those reporting cSHS as “somewhat harmful” (OR = 2.6, 95%CI = 2.2–3.1) or “mostly safe” (OR = 1.4, 95%CI = 1.2–1.7) vs those reporting cSHS as “totally safe”. In each subgroup of cannabis smoking status, state cannabis use legalization, and children under the age of 6 living in the home, perceived harm was associated with a complete ban on in-home cannabis smoking.ConclusionsOur study demonstrates perceiving cSHS as harmful is strongly associated with having a complete in-home cannabis smoking ban. With almost a third of US adults perceiving cSHS as at least “mostly safe”, there is strong need to educate the general population about potential risks associated with cSHS exposure to raise awareness and encourage adoption of household rules prohibiting indoor cannabis smoking.